ea0029p1114 | Neuroendocrinology | ICEECE2012
Gajewska A.
, Wolinska-Witort E.
, Zielinska M.
, Krawczynska A.
, Antushevich H.
Hypothalamic neuropeptide PACAP is a potent endogenous stimulator of adenylate cyclase synthesis in gonadotrope cells. Previously we found that, in contrast to GnRH, also CuGnRH complex is able to induce cAMP/PKA pathway activity.The aim of the study was to determine whether CuGnRH can act via GnRH-R and/or PAC-1 receptors to stimulate cAMP/PKA intracellular signaling. Moreover, we compared PACAP and CuGnRH ability to activate cGMP/PKG ...