Searchable abstracts of presentations at key conferences in endocrinology

ea0063p511 | Calcium and Bone 2 | ECE2019

Gitelman’s syndrome with concomitant primary hyperparathyroidism – case report

Krcma Michal

Gitelman’s syndrome, rare (lifetime prevalence 1:5000) autosomal recessive tubulopathy, is caused by SLC12A3 gene mutation (encoding part of sodium-chloride channel and magnesium channel). Typical finding is low level of potassium and magnesium due to increased output, secondary hyperaldosteronism and hypocalciuria. In this case, we present 28 years old woman with 1 year nonspecific conditions similar to hyperventilation tetanic cramps: muscle fatigue, cluster headache, n...

ea0049ep293 | Calcium & Vitamin D metabolism | ECE2017

18F-choline PET/MRI in patients with primary hyperparathyroidism and negative sestamibi SPECT/CT – report of two cases

Krcma Michal

Primary hyperparathyroidism is a common disorder which is curable by surgery. Exact localisation of parathyroid adenoma is essential for minimal invasive approach. The gold standard is sestamibi SPECT/CT nowadays - but fails in approximately 10% cases. In last 3 years some case report with 18F-choline PET/CT were published. We describe two cases with SPECT/CT invisible parathyroid adenoma.First case was 36y/o woman, with osteopenia diagnosed after pregna...

ea0035p589 | Endocrine tumours and neoplasia | ECE2014

Asymptomatic advanced neuroendocrine ovarian tumor: case report

Krcma Michal

Introduction: Incidence of neuroendocrine neoplasms is still growing very rapidly. Many of these tumours are long term asymptomatic, definitive diagnose is confirmed in very advanced stage and make treatment difficult. Our case report illustrates diagnostic contribution of endoscopic adrenal biopsy.Our patient was a woman, 68 years old in time of diagnosis, with good quality of life. One year before she was undergone hysterectomy with bilateral adnexecto...

ea0099ep241 | Calcium and Bone | ECE2024

9-year remission of severe primary hyperparathyroidism after high-dose cinacalcet treatment: case report

Krcma Michal

Introduction: Parathyroid adenomas with marked hypercalcemia need in most of cases surgical treatment. Calcimimetic treatment is usually a bridging therapy to correct hypercalcemia (in combination with other approaches, e.q. bisphosphonates). We describe case of conservative treatment in a patient in whom surgical therapy was not possible due to severe acute pancreatitis and where a high dose of calcimimetics led to clinical, laboratory and graphic remission with the possibili...

ea0070aep752 | Pituitary and Neuroendocrinology | ECE2020

FDG PET contribution to ectopic prolactinoma diagnosis - case report

Krcma Michal , Fuchsova Radka

Pituitary adenomas are in the majority of cases diagnosed by magnetic resonance imaging (MRI). In some cases, especially in functional tumors, there are too small adenomas for MRI resolution and we need other diagnostic modality (including petrosal sinus catheterization for laterality). Usefulness of positron emission tomography (PET) with fluorodeoxyglucose was demonstrated in some case report. In this case, we present 36 y/o women with no other comorbidities, which came at f...

ea0032p50 | Adrenal cortex | ECE2013

Oncocytic adrenal carcinoma with production of testosterone and cortisol: case report

Krcma Michal , Dvorakova Eva

We describe case of 29-year woman with no concomitant illneses in her history and with negative family history in sense of adrenal or cancer disease.She came first in February 2012 for secondary hypomenorrhea lasting for 3 months, hirsutism and worsening of acne. Laboratory examination reveals markedly elevated free testosterone (9.6 nmol/l) and slightly elevated morning cortisol (687.4 nmol/l) with almost no suppresion in low dose dexamethasone suppresi...

ea0032p38 | Adrenal cortex | ECE2013

Endosonography-guided fine-needle aspiration biopsy in differential diagnosis of adrenal gland tumours – pilot study

Krcma Michal , Hejda Vaclav , Dvorakova Eva

Introduction: Adrenal incidentaloma is a problem with increasing importance. There are CT-density and washout criteria for distinction between adrenal adenoma and other tumours, there are well established protocol of screening for malignancy and/or hormonal dysfunction. But there remains small portion of atypical adenoma where detailed diagnostic is needed. One relatively new option is endosonography-guided fine-needle aspiration biopsy.Aim: To assess va...

ea0022p840 | Thyroid | ECE2010

Isolated maternal hypothyroxinemia in women with gestational diabetes mellitus and its connection to necessity of insulinotherapy

Krcma Michal , Dvorakova Eva , Cechurova Daniela , Vokurkova Lenka , Rusavy Zdenek

Introduction: Isolated maternal hypothyroxinemia leads to higher prevalence of children autism, attention-deficit/hyperactivity disorder and mild cognitive deficiency. Frequency of hypothyroxinemia among women with gestational diabetes mellitus (GDM) is unclear and routine screening is not well established.Objective: Find prevalence of maternal isolated hypothyroxinemia in women with GDM and assess relations with necessity of insulinotherapy.<p class...

ea0041gp12 | Adrenal (1) | ECE2016

Congenital adrenal hyperplasia (CAH) in adulthood

Vrbikova Jana , Frysak Zdenek , Cap Jan , Krcma Michal , Cifkova Renata , Lanska Vera

Background and aim: Up to now, there is paucity of studies concerning health status in adults with congenital adrenal hyperplasia (CAH). We aimed to examine a group of adult CAH patients from different Czech centers.Methods: Serum lipids, glucose, blood pressure and anhtropometrics were compared in 31 males and 71 females with CAH 21-hydroxylase deficiency and in healthy population from Czech post-MONICA study (1% random population sample).<p class="...

ea0035p884 | Pituitary Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2014

Register of sellar tumors: RESET: diagnostics and therapy of acromegaly in Czech and Slovak Republics

Hana Vaclav , Svancara Jan , Bandurova Lubomira , Brabec Petr , Cap Jan , Durovcova Viktoria , Dvorakova Eva , Hana Vaclav , Jarkovska Zuzana , Kentos Peter , Klimes Daniel , Krcma Michal , Krsek Michal , Lazurova Ivica , Olsovska Vera , Podoba Jan , Pura Mikulas , Sasikova Michaela , Stary Karel , Strenkova Jana , Siprova Helena , Steno Juraj , Trejbalova Ludmila , Vanuga Peter , Wagnerova Hedviga , Weiss Vladimir , Zeman Dalibor , Dusek Ladislav , Marek Josef

Acromegaly is usually diagnosed after several years of duration. The multimodal therapy – surgery, radiotherpy, pharmacotherapy – is necessary in the majority of patients. Register of sellar tumors (RESET) collecting data of patients from eight tertiary centers in the Czech and Slovak Republics since the year 2000 was established in 2008.Aim of analysis: Evaluation of diagnostics of acromegaly and effectiveness of its treatment in a daily pract...