Searchable abstracts of presentations at key conferences in endocrinology

ea0081p519 | Adrenal and Cardiovascular Endocrinology | ECE2022

Brain Structure in a cohort of young adult patients with Autoimmune Addison’s Disease

van't Westeinde Annelies , Padilla Nelly , Strom Sara , Kampe Olle , Bensing Sophie , Lajic Svetlana

Background: Both cortisol and other adrenal hormones are well known to affect brain structure and function throughout development. Due to destruction of the adrenal cortex, patients with Autoimmune AddisonÂ’s disease (AAD) lack production of adrenal hormones and therefore receive lifelong replacement of cortisol and aldosterone, and, for some female patients dehydroepiandrosterone (DHEA). However, replicating the natural rhythm of secretion is difficult, and patients are o...

ea0013s46 | Management of endocrine disorders in pregnancy: the mother and the child | SFEBES2007

CAH – pregnancy and antenatal glucocorticoid treatment

Lajic Svetlana , Nordenström Anna , Hirvikoski Tatja , Wedell Anna , Ritzén Martin

In foetuses at risk of virilising CAH, prenatal treatment can be offered by administration of dexamethasone (DEX) via the mother in order to prevent genital malformations. Accumulating evidence from animal studies and epidemiological data raise concerns regarding the long term consequences of excess glucocorticoids on the developing foetus. The European study PREDEX is organized as an open, controlled, non-randomised, multicentre trial. The impact of DEX on the general well-be...

ea0022h1.4 | Oral Communications Highlights 1 | ECE2010

Physiological rescue by functional complementation of mutated LH receptors in transgenic mice

Rivero-Muller Adolfo , Chou Yen-Yin , Lajic Svetlana , Hanyaloglu Aylin , Jonas Kim , Rahman Nafis , Ji Tae , Huhtaniemi Ilpo

The LH receptor (LHR) is a 7-transmembrane domain G-protein coupled receptor (GPCR) mainly expressed in the gonads with a major role in the development and maintenance of gonadal steroidogenesis and gametogenesis. Its ligand LH, secreted by the pituitary gland, binds to the extracellular domain of LHR triggering a conformational change in the transmembrane domain and leading to activation of intracellular signalling cascades.As a member of the GPCR famil...

ea0073pep4.8 | Presented ePosters 4: Reproductive and Developmental Endocrinology | ECE2021

Current clinical practice of prenatal dexamethasone treatment in at risk pregnancies for classic 21‑hydroxylase deficiency in Europe

Nowotny Hanna F. , Blankenstein Oliver , Neumann Uta , Ahmed S. Faisal , Allen Stephanie , Baronio Federico , Battelino Tadej , Bertherat Jérôme , Bonomi Marco , de la Perrière Aude Brac , Tardy Véronique , Brucker Sara , Cappa Marco , Chanson Philippe , Bouvattier Claire , Colao Annamaria , Cools Martine , Davies Justin , Fenske Wiebke K. , Ghigo Ezio , Højbjerg Gravholt Claus , Hübner Angela , Husebye Eystein Sverre , Juul Anders , Kiefer Florian W. , Léger Juliane , Meyer Gesine , Phylactou Leonidas A. , Rohayem Julia , Russo Gianni , Scaroni Carla , Touraine Philippe , Unger Nicole , Hedi L. Claahsen-van der Grinten , Vojtková Jarmila , Yeste Diego , Günther Dörr Helmut , Lajic Svetlana , Reisch Nicole

BackgroundPrenatal dexamethasone treatment (Pdex) has been used since the 1980s to prevent virilization in female offspring suspected to have congenital adrenal hyperplasia (CAH). However, due to lack of strong evidence for its best practice as well as limited data regarding longterm adverse effects, use of dex is highly controversial. This study reveals the current medical practice regarding Pdex in female fetuses at risk of CAH due to 21hydroxylase def...