Searchable abstracts of presentations at key conferences in endocrinology
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European Congress of Endocrinology 2021

22 May 2021 - 26 May 2021

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The European Congress of Endocrinology provides a global platform for the international endocrine community to discuss the latest advances in the field.

Presented Eposters

Presented ePosters 4: Reproductive and Developmental Endocrinology

ea0073pep4.1 | Presented ePosters 4: Reproductive and Developmental Endocrinology | ECE2021

Effect of oral contraceptives containing estradiol valerate vs. ethinyl estradiol combined with dienogest on biomarkers of coagulation – a randomized clinical trial

Haverinen Annina , Luiro Kaisu , Szanto Timea , Kangasniemi Marika , Hiltunen Leena , Sainio Susanna , Piltonen Terhi , Lassila Riitta , Tapanainen Juha , Heikinheimo Oskari

ObjectiveTo compare the effects of combined oral contraceptives (COCs) containing estradiol valerate (EV) and dienogest (DNG) with ethinyl estradiol (EE) and DNG on biomarkers of coagulation: thrombin generation (TG), prothrombin fragments F1+2 (F1+2) and D-dimer (D-Di). A DNG-only preparation was included as a control.BackgroundCOC use increases the risk of venous thromboembolism (VTE) 2-6-fold compa...

ea0073pep4.2 | Presented ePosters 4: Reproductive and Developmental Endocrinology | ECE2021

Immunological and inflammatory biomarkers in non-obese patients affected by PCOS, correlation between hormonal and metabolic parameters: preliminary data

Bruno Carmine , Vergani Edoardo , Napodano Cecilia , Pocino Krizia , Stefanile Annunziata , Gulli Francesca , Oliva Alessandro , Basile Umberto , Mancini Antonio

ObjectivePolicystic ovary syndrome (PCOS) is a multifactorial disease characterized by reproductive and metabolic impairments. PCOS patients could present anovulation, hirsutism and infertility as well as higher prevalence of metabolic syndrome, glucose intolerance and diabetes. Insulin-resistance (IR) together with hyperandrogenism represent the main players, with reciprocal influences in a vicious circle: insulin promotes androgen secretion in thecal c...

ea0073pep4.3 | Presented ePosters 4: Reproductive and Developmental Endocrinology | ECE2021

Effects of a very low-calorie ketogenic diet on androgen levels in overweight/obese men: a single-arm uncontrolled study

Cignarelli Angelo , Conte Eleonora , Genchi Valentina Annamaria , Giordano Fiorella , Leo Simona Di , Perrini Sebastio , Natalicchio Annalisa , Laviola Luigi , Giorgino Francesco

Low levels of testosterone and SHBG levels are often present in subjects with overweight and obesity; functional hypogonadism further alters the metabolic balance and may drag subjects in a sort of vicious cycle, reducing exercise and energy expenditure. The very low-calorie ketogenic diet (VLCKD) has been reported to rapidly reduce body weight, glycaemia and insulinemia, but its effects on total testosterone (TT) and SHBG levels are less clear. We thus aimed to evaluate the r...

ea0073pep4.4 | Presented ePosters 4: Reproductive and Developmental Endocrinology | ECE2021

Insulin production by human spermatozoa in response to glucose stimuli

Carrageta David F. , Oliveira Pedro F. , Barros Alberto , Monteiro Mariana P. , Alves Marco G.

IntroductionMetabolic homeostasis in the testis is essential for a healthy spermatogenesis. Insulin is regarded as one of the most important intervenients in the metabolic regulation of spermatogenesis, where it acts directly on the differentiation of spermatogonia into primary spermatocytes or indirectly through the metabolic modulation of Sertoli cells. Additionally, insulin is hypothesized to play a major role on human spermatozoa capacitation, althou...

ea0073pep4.5 | Presented ePosters 4: Reproductive and Developmental Endocrinology | ECE2021

Effects of metformin withdrawal after long and short term treatment in PCOS: observational longitudinal study

Jensterle Mojca , NIka Aleksandra Kravos Tramsak , Janez Andrej

BackgroundMetformin plays a consolidated role in the management of polycystic ovary syndrome (PCOS). However, there is no clear answer on how long we should treat and on how long its beneficial impact sustain after we stop treatment. We compared the effects of metformin withdrawal after long-term (LT) and short term (ST) treatment in PCOS women that had previously well responded to metformin.MethodsWe conduct...

ea0073pep4.6 | Presented ePosters 4: Reproductive and Developmental Endocrinology | ECE2021

The effect of decamethylcyclopentasiloxane exposure to maternal mice in offspring behavior

Yi Donglin , Kim Kang Min , Lee Bonn , Lee Minsu , Eui-Bae Jeung

Decamethylcyclopentasiloxane(D5) is one of the most common chemical ingredient for cosmetic products, cleansing agents, hairdye, dry cleaning solvent and personal hygiene supplies. D5 is also known as estrogenic chemical. It can be absorbed through skin, airosol, and even oraly. People are exposed to D5 in daily environment. However, the risk of prenatal exposure to D5 has not yet been fully understood. Recent research shows that imbalance of dam’s estrogen induces brain ...

ea0073pep4.7 | Presented ePosters 4: Reproductive and Developmental Endocrinology | ECE2021

Functional ovarian reserve in women with infertility and euthyroidism: what is the role of thyroid autoimmunity?

Alexandra Festas Silva Diana , Carvalho Tânia , Maresch Ângela , Catarino Diana , Fadiga Lúcia , Reis Guiomar Joana , Gomes Leonor , Leitão Fátima , Cortesão Paulo , Almeida Santos Teresa , PAIVA Isabel

IntroductionThyroid dysfunction is the most common endocrine disorder in women of childbearing age, and is associated with menstrual irregularities, anovulation and infertility. Whether it is thyroid function and/or thyroid autoimmunity (AI) that affects functional ovarian reserve remains to be clarified.AimTo evaluate the association between functional ovarian reserve and thyroid AI in women with infertility...

ea0073pep4.8 | Presented ePosters 4: Reproductive and Developmental Endocrinology | ECE2021

Current clinical practice of prenatal dexamethasone treatment in at risk pregnancies for classic 21‑hydroxylase deficiency in Europe

Nowotny Hanna F. , Blankenstein Oliver , Neumann Uta , Ahmed S. Faisal , Allen Stephanie , Baronio Federico , Battelino Tadej , Bertherat Jérôme , Bonomi Marco , de la Perrière Aude Brac , Tardy Véronique , Brucker Sara , Cappa Marco , Chanson Philippe , Bouvattier Claire , Colao Annamaria , Cools Martine , Davies Justin , Fenske Wiebke K. , Ghigo Ezio , Højbjerg Gravholt Claus , Hübner Angela , Husebye Eystein Sverre , Juul Anders , Kiefer Florian W. , Léger Juliane , Meyer Gesine , Phylactou Leonidas A. , Rohayem Julia , Russo Gianni , Scaroni Carla , Touraine Philippe , Unger Nicole , Hedi L. Claahsen-van der Grinten , Vojtková Jarmila , Yeste Diego , Günther Dörr Helmut , Lajic Svetlana , Reisch Nicole

BackgroundPrenatal dexamethasone treatment (Pdex) has been used since the 1980s to prevent virilization in female offspring suspected to have congenital adrenal hyperplasia (CAH). However, due to lack of strong evidence for its best practice as well as limited data regarding longterm adverse effects, use of dex is highly controversial. This study reveals the current medical practice regarding Pdex in female fetuses at risk of CAH due to 21hydroxylase def...