Searchable abstracts of presentations at key conferences in endocrinology
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European Congress of Endocrinology 2021

Online
22 May 2021 - 26 May 2021

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The European Congress of Endocrinology provides a global platform for the international endocrine community to discuss the latest advances in the field.

Presented Eposters

Presented ePosters 3: Pituitary and Neuroendocrinology

ea0073pep3.1 | Presented ePosters 3: Pituitary and Neuroendocrinology | ECE2021

Genetic profiling of a cohort of Italian patients with ACTH-secreting pituitary tumors and characterization of a novel USP8 gene variant

Treppiedi Donatella , Barbieri Anna Maria , Muro Genesio Di , Marra Giusy , Mangili Federica , Catalano Rosa , Locatelli Marco , Spada Anna , Arosio Maura , Peverelli Erika , Mantovani Giovanna

CushingÂ’s Disease (CD) is a rare condition characterized by an overproduction of ACTH by an ACTH-secreting pituitary tumor resulting in excess of cortisol release by the adrenal glands. Somatic mutations in the deubiquitinases USP8 and USP48, and in BRAF genes, have been reported in a subset of patients affected by CD. Aim of this study was to characterize the genetic profile of a cohort of 66 patients with ACTH-secreting tumors, searching for somatic mutations in USP8, U...

ea0073pep3.2 | Presented ePosters 3: Pituitary and Neuroendocrinology | ECE2021

Safety results from MPOWERED, a phase 3 trial of oral octreotide capsules in adults with acromegaly

Freda Pamela U. , Fleseriu Maria , Dreval Alexander V. , Pokramovich Yulia , Bondar Irina , Isaeva Elena , Huang Wenyu , Molitch Mark E. , Macut Djuro P. , Leonova Nina , Raverot Gerald , Yossi Gilgun-Sherki , Ludlam William H. , Patou Gary , Haviv Asi , Gordon Murray B. , Biermasz Nienke , Melmed Shlomo K. , Strasburger Christian J.

BackgroundInjectable somatostatin receptor ligands (iSRLs) have been a mainstay in acromegaly treatment. Oral octreotide capsules (OOC; MYCAPSSA®) were recently approved in the USA. Results from the placebo-controlled CHIASMA OPTIMAL and open-label CH-ACM-01 studies showed an OOC safety profile consistent with that of iSRLs with no new or unexpected safety signals. Results of the MPOWERED trial have enabled a comparison of OOC safety and ...

ea0073pep3.3 | Presented ePosters 3: Pituitary and Neuroendocrinology | ECE2021

Insulinoma-associated protein 1 (INSM1) may serve as a sensitive and specific immunohistochemical and molecular biomarker of neuroendocrine differentiation in pancreatic neuroendocrine tumors (PNETs)

Katalinic Darko , Aleric Ivan , Vcev Aleksandar , Kattner Elke

IntroductionInsulinoma-associated-1 (INSM1), encoded by the INSM1 gene is key factor in pancreatic endocrine, sympatho-adrenal and pan-neurogenic development. It has also been identified in multiple tumors of neuroendocrine origin but not thoroughly investigated as a potential neoplastic biomarker. The aim of the study was to evaluated INSM1 as a semiquantitative immunohistochemical biomarker as well as quantitative reverse transcriptase polymer...

ea0073pep3.4 | Presented ePosters 3: Pituitary and Neuroendocrinology | ECE2021

Benefits and harms of pituitary surgery for prolactinomas. A systematic review and meta-analysis

Marie Gry Rejkæ Sørensen , Andreassen Mikkel , Springborg Jakob , Jesper Krogh

ObjectiveThe objective of this systematic review was to assess the proportion of patients with prolactinomas that obtain remission or experience adverse effects after transsphenoidal surgery.DesignA systematic review. Registered at PROSPERO, registration number CRD42020213002MethodsA bibliographical search of PubMed and Embase was performed and last updated on Sep...

ea0073pep3.5 | Presented ePosters 3: Pituitary and Neuroendocrinology | ECE2021

Endocrine function after tanssphenoidal surgery in patients with non-functioning pituitary adenomas: A systematic review and meta-analysis

Pedersen Mathias , Andreassen Mikkel , Springborg Jakob , Jesper Krogh

BackgroundSurgical resection is indicated in patients with non-functioning pituitary adenomas (NFPA) causing visual defects or tumor growth in proximity to the optic chiasm. The aim of this study was to systematically assess the benefits and harms of pituitary endocrine function after transsphenoidal surgery in patients with NFPAs.MethodsThis study was conducted a systematic review that searched for potential...

ea0073pep3.6 | Presented ePosters 3: Pituitary and Neuroendocrinology | ECE2021

Comparative study of growth hormone stimulation levels in growth hormone deficient children vs children with idiopathic short stature

Sofia Leka-Emiri , Athanasouli Fani , Tampouratzi Dimitra , Kafetzi Maria , Dikaiakou Eirini , Petrou Vasilios , Vlachopapadopoulou Elpis , Michalakos Stefanos

IntroductionShort stature (SS) assessment includes the documentation of growth hormone (GH) secretion via GH stimulation tests.ObjectivesTo study retrospectively GH stimulation test results among Greek children with SS and investigate differences among GH deficient (GHD) children vs idiopathic short stature (ISS).MethodsData were collected retrospectively from 190...

ea0073pep3.7 | Presented ePosters 3: Pituitary and Neuroendocrinology | ECE2021

Transcriptome alteration landscape of pituitary neuroendocrine tumour tissue

Saksis Rihards , Megnis Kaspars , Peculis Raitis , Niedra Helvijs , Balcere Inga , Konrade Ilze , Steina Liva , Pirags Valdis , Rovite Vita

Pituitary neuroendocrine tumors (PitNETs) are non-metastatic neoplasms of the pituitary that may overproduce hormones leading to systemic disorders or tumor mass effects causing headache, vertigo, or visual impairment. The overall estimated clinical prevalence of PitNETs is 1 in 400 to 1 in 1000 people. Although the pathogenesis of PitNETs has been extensively studied the molecular factors underlying tumorigenesis, remission, and therapy response of PitNETs are still unclear. ...

ea0073pep3.8 | Presented ePosters 3: Pituitary and Neuroendocrinology | ECE2021

Temporary oral NaCl tablets safely increase serum sodium in hospitalised elderly patients with hyponatraemia secondary to refractory idiopathic syndrome of inappropriate diuresis (SIAD)

Latorre Julia Calvo , Senanayake Russell , Bashari Waiel A

IntroductionHyponatraemia is the most common electrolyte abnormality encountered within the inpatient setting and is associated with increased morbidity, mortality and length of hospital stay. It compromises a spectrum of symptoms, from being asymptomatic to varying degrees of neurological disturbances including gait abnormalities with increased risk of falls, confusion and rarely seizures. This is of particular relevance in the midst of an aging populat...