Searchable abstracts of presentations at key conferences in endocrinology

ea0070ep516 | Thyroid | ECE2020

Treatment of hypothyroidism does not affect whole-body oxidative stress, as measured by biomarkers of RNA and DNA damage

Ryom Riis Kamilla , Larsen Camilla , Winther Kristian H. , Larsen Emil L. , Ellervik Christina , Hegedüs Laszlo , Brix Thomas , Poulsen Henrik E. , Bonnema Steen J.

Background: Hyperthyroidism as well as hypothyroidism have been associated with oxidative stress, caused by an imbalance between pro-oxidants and antioxidants. Oxidative stress may damage the genomic apparatus and other cellular structures. Urinary excretion of 8-oxo-7.8-dihydroguanosine (8-oxoGuo) and 8-oxo-7.8-dihydro-2’-deoxyguanosine (8-oxodG), respectively, represent global RNA and DNA oxidation, thus reflecting oxidatively generated modification of nucleic acids in...