ea0065p237 | Metabolism and Obesity | SFEBES2019
Villalobos Elisa
, Criollo Alfredo
, Schiattarella Gabriele
, Altamirano Francisco
, Gillette Thomas
, Lavandero Sergio
, Hill Joseph
Background: Cardiac fibrosis is a common biological response to cardiovascular injury. Maladaptive cardiac fibrosis as observed in patients with hypertension, obesity or diabetes mellitus contributes to contractile dysfunction and electrophysiological disorders. Currently, there is controversy regarding whetherexposure to a high fat diet (HFD) in isolation induces cardiovascular damage and fibrosis. Here, we set out to explore the contribution of different models of obesity to...