Searchable abstracts of presentations at key conferences in endocrinology

ea0028p341 | Thyroid | SFEBES2012

The negative psycho-social impact of moderately active Thyroid Eye Disease

Jackson Sue , Murray Jane , Lee Richard

Introduction: Thyroid eye disease (TED) is a visually disabling and cosmetically disfiguring condition. There is a paucity of research on the psychosocial impact of TED. One of the aims of this research is to improve understanding of the extent and type of psychosocial distress experienced by TED patients.Method: 77 patients with TED were recruited (53 female, 24 male; aged between 25 and 73 years, average age=47.6±11.6 yrs; 58% Caucasian). Particip...

ea0050oc2.2 | Clinical Highlights | SFEBES2017

Combined immunosuppression & radiotherapy in thyroid eye disease (CIRTED) trial: A multi-centre, double-masked, factorial randomised controlled trial

Taylor Peter , Rajendram Rathie , Uddin Jimmy , Lee Richard , Dayan Colin

On behalf of the Combined immunosuppression & radiotherapy in thyroid eye disease (CIRTED) InvestigatorsBackground: Thyroid eye disease is an inflammatory orbital condition which causes visual dysfunction and psychological morbidity. Current evidence is conflicting on the benefit of radiotherapy and antiproliferative immunosuppression in addition to systemic corticosteroid treatment. In particular, little is known about clinical outcomes mor...

ea0050oc2.2 | Clinical Highlights | SFEBES2017

Combined immunosuppression & radiotherapy in thyroid eye disease (CIRTED) trial: A multi-centre, double-masked, factorial randomised controlled trial

Taylor Peter , Rajendram Rathie , Uddin Jimmy , Lee Richard , Dayan Colin

On behalf of the Combined immunosuppression & radiotherapy in thyroid eye disease (CIRTED) InvestigatorsBackground: Thyroid eye disease is an inflammatory orbital condition which causes visual dysfunction and psychological morbidity. Current evidence is conflicting on the benefit of radiotherapy and antiproliferative immunosuppression in addition to systemic corticosteroid treatment. In particular, little is known about clinical outcomes mor...

ea0077op1.1 | Thyroid | SFEBES2021

Factors predicting long-term outcome and the need for surgery in Graves Orbitopathy extended follow-up from the CIRTED Trial

Taylor Peter , Rajendty -45tyram Rathie , Uddin Jimmy , Lee Richard , Dayan Colin

Context: Thyroid eye disease is disabling and disfiguring and has a substantial negative impact on quality of life. Medical therapies to reduce inflammation are widely used, but there is limited data from clinical trials beyond 6 months of follow-up. Methods: 3 year follow-up of a subset of the CIRTED trial (n = 68) which randomized patients to receive high-dose oral steroid with azathioprine/placebo and radiotherapy/sham radiotherapy. We compar...

ea0037gp.02.06 | Adrenal (1) | ECE2015

DNA methylation of FKBP5 and its relationship with hippocampal volumes in Cushing's syndrome patients

Resmini Eugenia , Santos Alicia , Aulinas Anna , Webb Susan , Gomez-Anson Beatriz , Cox Olivia , Lee Richard

Introduction: FKBP5 is a protein that regulates glucocorticoid receptor sensitivity, via an ultra-short negative feedback mechanism. Variations in the FKBP5 gene can influence the response to glucocorticoids (GC). Hypercortisolaemia plays a role on impairment of brain function and could be mediated by epigenetic variations of the FKBP5 gene. CushingÂ’s syndrome (CS), a disease characterized by hypercortisolaemia, is associated with memory deficits, lower ...