Searchable abstracts of presentations at key conferences in endocrinology

ea0049gp79 | Diabetes & complications 1 | ECE2017

The rs2292239 polymorphism in the ERBB3 gene is associated with risk for type 1 diabetes mellitus

Crispim Daisy , Dieter Cristine , Lemos Natalia , Assmann Tais , Duarte Guilherme , Dorfman Luiza , Bauer Andrea

Background and Aim: Type 1 diabetes mellitus (T1DM) is an autoimmune disease resulting from the complex interaction among multiple genes, environmental factors and the immune system. Genome-wide association studies identified ERBB3 (Erb-b2 receptor tyrosine kinase 3) gene as a main susceptibility locus for T1DM. This gene encodes a member of the family of intracellular receptors of protein tyrosine kinases, which activates multiple signaling pathways including PI3K-Ak...

ea0035p353 | Diabetes (epidemiology, pathophysiology) | ECE2014

Association between Asp299Gly and Thr399Ile polymorphisms in TLR4 gene and type 2 diabetes mellitus: Case-control study and meta-analysis

Assmann Tais , Lemos Natalia , Brondani Leticia , Carlessi Rodrigo , Canani Luis Henrique , Crispim Daisy

Introduction: Polymorphisms in genes that encode proteins of the innate immune system, such as the toll-like receptor 4 (TLR4), could affect the immune response as well as the prevalence of type 2 diabetes mellitus (T2DM). Activated TLR4 induces expression of a spectrum of proinflammatory cytokines, which have been implicated in insulin resistance. Some studies have reported associations of the TLR4 Asp299Gly and Thr399Ile polymorphisms with T2DM. However, ot...