Endocrine Abstracts

Introduction: Cushing’s disease (CD) is five to six times more common than Cushing’s syndrome, with a peak incidence at 20–40 years. It is usually an ACTH-secreting microadenoma, the local invasion being associated with one third of macroadenomas. The treatment of choice is the transsphenoidal surgery, but nearly 50% of the patients with macroadenomas ultimately require additional treatment. Cabergoline appears to be an attractive treatment option for CD, consid...

Introduction: Primary aldosteronism (PA) accounts for 20% of patients with resistant hypertension and is one of its leading causes. Options of treatment include adrenalectomy and mineralocorticoid receptor antagonists (MRAs). Latest studies suggest that both may paradoxically lead to a decline in estimated glomerular filtration rate (eGFR), explained by the masked glomerular hyperfiltration associated to PA before treatment.Case report: A 56 years old ma...