Endocrine Abstracts

This case shows the potential unreliability of a single ACTH assay in the context of Cushing’s syndrome and need for better ways of measuring ACTH and precursors. A 35 year-old lady presented with severe abdominal pain and cushingoid features. CT scan showed a 2.9 cm right adrenal nodule. Investigations: 24-hour UFC 446 nmol/l, post-dexamethasone cortisol level of 572 nmol/l. The referring hospital found a suppressed ACTH < 0.1ng/l consistent with ACTH-independent Cus...

Introduction: The optimal management approach for incidental non-functioning pituitary microadenomas (micro-NFAs) is unclear. We aimed to capture current UK practice and identify changes following a 13-year interval.Methods: Two surveys on micro-NFAs were conducted in 2009 and 2022 (advertised by Society for Endocrinology). Hormonal/imaging evaluations were explored.Results: 2022: 150 clinicians participated. At baseline, ≥14...

Introduction: Definitive treatment of hyperthyroidism with Radioactive Iodine (RAI) ablation therapy has been associated with weight gain from RAI induced hypothyroidism. Literature on weight data of post-RAI patients following normalisation of thyroid function is equivocal.Objective: We undertook a retrospective study to evaluate the effect of RAI on weight in Hyperthyroid patients in University Hospitals of Leicester NHS Trust (UHL). <p class="abst...

Introduction: Dopamine Agonists are important in the management of endocrine disorders such as acromegaly and hyperprolactinaemia. Recent studies have shown that Cabergoline used in high doses to treat Parkinson’s disease is associated with cardiac valve fibrosis.Methods: We identified patients on long term high-dose cabergoline for the management of acromegaly. The following data was analysed: demographic data, duration of treatment, cumulative dos...

Thyroid cancer is the most common endocrine malignancy accounting for 1% of new cancer cases each year. Even after treatment, one in five patients develop recurrence eventually. Therefore, close follow up is crucial after treatment. Current tumour biomarkers are not perfect, and there is a need for a more sensitive and specific way of detecting early recurrence. Liquid biopsies have emerged as a novel marker in tumour surveillance and monitoring response to treatment. In parti...

Introduction: We report a rare case of hyperandrogenism associated with portal hypertension as a result of Alagille syndrome.Case report: 21-yr old female presented with primary amenorrhoea and mild hirsutism. There was no history of delayed puberty or acne. Past medical history: Alagille syndrome (biliary tree hypoplasia, liver disease, portal hypertension, splenomegaly, Barrett’s oesophagus and pulmonary stenosis). Drug ...

59 year old woman with relapsing remitting multiple sclerosis (MS), not under Neurology follow-up was privately consulting a nutritionist based in Ireland and following the Coimbra protocol1 since December 2016. This included colecalciferol (1000-170000 IU/ day), vitamin B-complex and trace elements. Dose adjustments were advised during weekly skype consultations based on blood tests (via General Practitioner) and symptoms.<p class="abstex...

A 21 year old Asian woman presented with relapse of Neuromyelitis Optica (NMO) spectrum disorder, diagnosed aged 16. She had headache, dizziness, right hand weakness and severe hyponatraemia (serum sodium [Na+] 116 [135–145]). Emesis, dominant in previous relapses, was absent – she was euvolaemic. Serum (Seosm) and urine (Uosm) osmolalities were 250 and 468 mosm/kg respectively, thyroid function ...

Introduction: We report a rare case of hyperandrogenism associated with portal hypertension as a result of Alagille syndrome.Case report: 21-yr old female presented with primary amenorrhoea and mild hirsutism. There was no history of delayed puberty or acne. Past medical history: Alagille syndrome (biliary tree hypoplasia, liver disease, portal hypertension, splenomegaly, Barrett’s oesophagus and pulmonary stenosis). Drug ...

59 year old woman with relapsing remitting multiple sclerosis (MS), not under Neurology follow-up was privately consulting a nutritionist based in Ireland and following the Coimbra protocol1 since December 2016. This included colecalciferol (1000-170000 IU/ day), vitamin B-complex and trace elements. Dose adjustments were advised during weekly skype consultations based on blood tests (via General Practitioner) and symptoms.<p class="abstex...