Searchable abstracts of presentations at key conferences in endocrinology

ea0050p043 | Bone and Calcium | SFEBES2017

Immunomodulation by vitamin D is associated with regulation of dendritic cell microRNAs

Li Danyang , Jeffery Louisa , Raza Karim , Hewison Martin

The hormonally active form of vitamin D, 1,25-dihydroxyvitamin D (1,25D) acting via the vitamin D receptor (VDR) is a potent transcriptional regulator, with effects on skeletal and extra-skeletal physiology. We have shown previously that skeletal responses to 1,25D also involve regulation of microRNAs (miRNAs); small non-coding RNAs with an emerging role in epigenetics. To assess the role of miRNAs in innate immune responses to 1,25D we utilised in v...

ea0050p043 | Bone and Calcium | SFEBES2017

Immunomodulation by vitamin D is associated with regulation of dendritic cell microRNAs

Li Danyang , Jeffery Louisa , Raza Karim , Hewison Martin

The hormonally active form of vitamin D, 1,25-dihydroxyvitamin D (1,25D) acting via the vitamin D receptor (VDR) is a potent transcriptional regulator, with effects on skeletal and extra-skeletal physiology. We have shown previously that skeletal responses to 1,25D also involve regulation of microRNAs (miRNAs); small non-coding RNAs with an emerging role in epigenetics. To assess the role of miRNAs in innate immune responses to 1,25D we utilised in v...

ea0044p45 | Bone and Calcium | SFEBES2016

Immunomodulation by vitamin D is associated with regulation of microRNAs

Li Danyang , Jeffery Louisa E. , Raza Karim , Hewison Martin

The active form of vitamin D, 1,25-dihydroxyvitamin D (1,25D), acting via the vitamin D receptor (VDR) is a potent regulator of gene expression, with effects on skeletal and extra-skeletal physiology. We have shown that actions of 1,25D on bone-forming osteoblasts also involve regulation of microRNAs (miRNAs) that play a key role in the functional development of these cells. In the current study, we have investigated miRNAs as mediators of innate and adaptive immune responses ...

ea0090p216 | Thyroid | ECE2023

UPLC-Q-TOF/MS-based metabolomics explored the metabolic mechanisms of thyroid cancer in different background

Sun Danyang , Li Xue , Wang Xuan , Ji Yanhui , Meng Zhaowei , Zheng Wei

Thyroid papillary carcinoma (PTC) is the most common endocrine tumor, HashimotoÂ’s thyroiditis (HT) is considered to be closely related to PTC pathogenesis, but their relationship still needs verification and exploration. Aim of the study. To analyze the differences and similarities of the metabolic mechanism of thyroid papillary carcinoma in normal and HT background, and to explore the relationship between HT and PTC. The Ultra performance liquid chromatography-q...