Endocrine Abstracts

Introduction: Pheochromocytomas and paragangliomas (PPGLs) are rare tumors of the chromaffin tissue characterised by catecholamine excess. Cardiovascular complications, such as hypertensive crisis and catecholamine-induced cardiomyopathy, are known to be the most frequent causes of life-threatening events in PPGLs patients.Design: We analysed records of patients diagnosed with PPGLs in one referral centre from Romania between 1976 and 2021 (n= 1...

Introduction: Bilateral pheochromocytomas (PHEOs) most often occur as components of hereditary syndromes: MEN2A, VHL disease or neurofibromatosis. The best surgical technique in such cases is yet disputed between cortical sparing or total adrenalectomy. Two important complications are related to each surgical technique: adrenal insufficiency (AI) or recurrence-which one is more harmful for the patient?Aim: To evaluate the complications (recurrence, AI) r...

Introduction: New-onset hyperandrogenism is rare in postmenopausal women and is usually associated with causes such as ovarian hyperthecosis, androgen-secreting tumor or medication. Patients with hyperandrogenism and breast cancer need a special attention when choosing the treatment.Case history: A 46-year old woman diagnosed with hormone receptor-positive breast cancer at 37 years old, for which she underwent surgery, chemotherapy, radiotherapy and horm...

Introduction: Pheochromocytoma is a rare tumor, representing a cause of secondary endocrine hypertension. Traditionally, prior to the widespread availability of imaging investigations, pheochromocytoma was diagnosed based on the triad: headache, palpitations and sweating. Diagnosis is crucial, as 40-50% of pheochromocytoma patients exhibit genetic mutations associated with multiple syndromes, such as MEN2 syndrome, succinate dehydrogenase enzyme mutations, neurofibromatosis ty...

Introduction: It is known that phaeochromocytoma penetrance in MEN2A syndrome steadily increases with age. In general, MEN2A related pheochromocytomas (PHEOs) have a benign evolution; however, some of them have an aggressive behaviour despite the same genetic background as the benign forms.Aim: To evaluate potential factors that may influence PHEO penetrance and tumor dimensions (age at diagnosis, MTC aggressiveness or genetic status).<p class="abste...

Introduction: Medullary thyroid cancer (MTC) is a thyroid neuroendocrine tumor with a genetic basis and average biological aggressiveness, with a 5-year survival rate of around 90%. However, the presence of calcitonin (CT) biomarker along with genetic beckground could further improve these data, by earlier diagnosis and proper surgical management of genetically predisposed patients.Patients and Methods: To set specific thresholds for basal CT and calcium...