Searchable abstracts of presentations at key conferences in endocrinology

ea0004dp8 | Diabetes, metabolism and cardiovascular | SFE2002

Fetal Macrosomia and the Oral Glucose Tolerance Test

John L , Lloyd J

Various criteria have been proposed to diagnose and treat gestational diabetes due to uncertainties about the influence of mild degrees of maternal glucose intolerance on pregnancy outcomes. We used receiver operating characteristics (ROC) curve analysis to correlate macrosomia (more than or equal to 4000g) with varying thresholds for the 2 hour 75 gm oral glucose tolerance test (OGTT) results in pregnant women screened at our hospital from 1998-2001.Wom...

ea0003p17 | Clinical Case Reports | BES2002

Management of thyrotoxicosis in a non-compliant pregnant woman

John L , Lloyd J

Management of Thyrotoxicosis in a Non-compliant Pregnant WomanA 23-year-old woman with Grave's disease presented to thyroid clinic 29 weeks into her first pregnancy having recently moved into the area. She had failed to attend hospital thyroid clinics elsewhere and frequently changed her address.Despite propylthiouracil 300 mg daily she had marked tremor, tachycardia 100 bpm, ophthalmopathy, and a large smooth goitre. TSH <0.0...

ea0019p147 | Diabetes, Metabolism and Cardiovascular | SFEBES2009

Effect of pre and postnatal diet on pancreatic beta-cell insulin and glucagon content

Lloyd L , Mobasheri A , Gardner D

Insulin resistance is associated with obesity, metabolic syndrome and hypertension. These risk factors for type 2 diabetes and cardiovascular disease may be programmed by the early diet. Previous studies have shown poor insulin sensitivity in obese relative to lean sheep. Here, we considered whether insulin sensitivity in pre- and postnatally nutritionally challenged sheep offspring was due to changes at the pancreatic level. Thirty-six twin-bearing ewes were randomly allocate...

ea0019p68 | Clinical practice/governance and case reports | SFEBES2009

Generalised glucocorticoid resistance diagnosed by chance

Owen E , Lloyd L , Wayte A , Wilton A

Generalised resistance to glucocorticoid is a rare familial or sporadic disease with partial target tissue insensitivity to glucocorticoids. Compensatory activation of the hypothalamo┬ľpituitary┬ľadrenal axis occurs with raised andrenocorticotrophic (ACTH) hormone levels and increased synthesis of adrenal steroids. The phenotype varies from asymptomatic to excess glucocorticoid, mineralocorticoid and androgenic effects.A 20-year-old female was fo...