Searchable abstracts of presentations at key conferences in endocrinology

ea0041ep285 | Clinical case reports - Pituitary/Adrenal | ECE2016

Polyglandular autoimmune Syndrome type 2/Schmidt’s syndrome

Machenahalli Pratibha , Shotliff Kevin

25-years-old lady presented to gastroenterologist with recurrent bouts of vomiting associated with abdominal pains, fatigue, muscle aches and dark tan. Initial biochemical profile and upper GI endoscopy were normal. On examination she had dark pigmentation of the palms well hydrated and haemodynamically stable. No family history of autoimmune conditions. She had traumatic laceration of the liver as a child, otherwise no significant past medical history.A...

ea0041ep951 | Pituitary - Clinical | ECE2016

Primary empty sella syndrome-is it familial?

Machenahalli Pratibha , Shotliff Kevin

Introduction: Empty sella syndrome is a condition in which sella turcica is partially or completely filled with CSF resulting in a displacement of normal pituitary gland. Primary empty sella is due to inherent weakness of diaphragm sella or to an increase in intracranial pressure which promotes herniation of arachnoid membranes in to pituitary fossa. More common in middle aged obese female and headache is the most common presenting symptom. It may be associated with one or mor...

ea0044ep6 | (1) | SFEBES2016

Prednisolone 3 mg once daily should be the glucocorticoid replacement for hypopituitarism

Machenahalli Pratibha , Choudhury Sirazum , Meeran Karim

A 33 year-old male bus driver with long standing pemphigus requiring high dose prednisolone, presented with acromegaly in 2001. MRI pituitary revealed a 2×2×0.5 cm pituitary adenoma and his GH levels of 14.8–16.4 nmo/L throughout and were not suppressible with glucose. His IGF1 was 191 nmol/l (normal range: 13–64 nmol/L), Prolactin 6,557 milliunit/L, testosterone 2 nmol/L and cortisol uninterpretable as he was on prednisolone. Trans-sphenoidal hypophysectom...

ea0086p108 | Neuroendocrinology and Pituitary | SFEBES2022

Dopamine agonist intolerance in prolactinoma- A management challenge to endocrinologist

Wellala Vindya , Machenahalli Pratibha , Kumarathunga Dineesha , Georgios Giovos , Puja Thadani

Introduction: Typically, patients with a microprolactinoma will have serum prolactin level between 2,000-4,000mIU/l. The primary goal of treatment is to normalise prolactin level and thereby improve symptoms associated with a raised prolactin. Dopamine (D2) agonists are the main stay of treatment with some patients unable to tolerate dopamine agonists rather than being resistant to the medication.Case report: A 26-year-old lady with a history of anxiety ...

ea0049gp29 | Adrenal 3 | ECE2017

Familial case of SDHB mutation presenting as a macroprolactinoma

Mills Edouard , Machenahalli Pratibha , Naqvi Ali , Todd Jeannie

Germline mutations in the succinate dehydrogenase subunit-B gene (SDHB) are well recognised for predisposing to head and neck paraganglioma, sympathetic paraganglioma, phaeochromocytoma and renal cell carcinoma. The co-existence with pituitary adenomas remains uncommon.We report a 31-year-old female who presented at age 29 years old with 9 months of secondary amenorrhoea. Prolactin was 3000 mIU/l and a 1.7-cm macroprolactinoma revealed on MR pituitary. T...

ea0049gp30 | Adrenal 3 | ECE2017

Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia with cyclical ectopic adrenocorticotrophic hormone secretion

Machenahalli Pratibha , Mills E , Ali N , Todd JF

DIPNECH is pre-invasive precursor to carcinoid tumors and tmorlets, most of which present with pulmonary symptoms. We present a case of ectopic cyclical ACTH producing DIPNECH.33-year lady presented with a short history of weight gain, abdominal striae, proximal myopathy and secondary amenorrhoea. She reported a previous episode with similar symptoms one year earlier which resolved spontaneously after a few weeks. Random cortisol 4000 nmol/l, ACTH 98 ng/...

ea0077p97 | Neuroendocrinology and Pituitary | SFEBES2021

Management of Complicated Pit-1 staining Non-functioning Pituitary macroadenoma in Pregnancy

Machenahalli Pratibha , Thandani Puja , Shad Amjad , Sherlala Khalid , Giovos Georgios , Dhingra Vandana , Randeva Harpal

Background: Incidence of non-functioning pituitary macroadenoma (NFPMA) is very rare in pregnancy. We describe a case of complicated non-functioning pituitary macroadenoma presented during pregnancy. 26 year old female at 21 weeks gestation presented to emergency services with worsening headaches, nausea and vomiting for 2-3 months. This was associated with transient double vision and confusion since 2 days. She was admitted to emergency department 3 weeks ago with vomiting an...

ea0077p229 | Neuroendocrinology and Pituitary | SFEBES2021

Case report: pituitary metastasis and Its diagnostic complexity

Chaudhury Nadia , Thadani Puja , Awala Orighomisan , Randeva Harpal , Correa Peter , Machenahalli Pratibha , Gholap Nitin

Background: Pituitary metastasis (PM) is a rare occurrence in malignancy, associated with poor prognosis. Only 7% of patients are symptomatic. High index of suspicion and prompt investigation are essential. We report a case of PM, highlighting challenges in diagnosis and management.Case Report: Sixty-six year old male was referred to endocrinology due to headaches and hyponatremia. He had metastatic colorectal carcinoma, treated with bowel, liver and lun...

ea0086p110 | Neuroendocrinology and Pituitary | SFEBES2022

Retrospective analysis of clinical, biochemical, radiological features of Craniopharyngioma

Pratibha Machenahalli C , Iqbal Asif , Shad Amjad , Smith Megan , Woods Leanne , Brown Ian , Randeva Harpal

Craniopharyngioma is a rare embryonic malformation of the Sellar/parasellar region. This harbors BRAF-V600E mutations. There are 2 Subtypes-Adamantinomatous and Papillary. Point prevalence of CP is around 2/100,000 with no variance by gender or race. CP has bimodal age distribution with peak incidence in the ages of 5-14 and 65-74 years. CP presents with following clinical features: Symptoms due to increased intracranial pressure-Nausea, headaches, visual impairments, hormone ...

ea0086p115 | Neuroendocrinology and Pituitary | SFEBES2022

Pituicytoma mimicking as a Non-functioning pituitary macroadenoma

Kumarathunga P.A.D.M. , Machenahalli Pratibha , Shad Amjad , Smith Megan , Thadani Puja , Wellala A.V.H. , Randewa Harpal

Background: Pituitary adenomas are the commonest Sellar neoplasm, there are number of other differential diagnosis based on histopathological features and immune histochemical characteristics. Pituicytomas are rare tumours of sellar and suprasellar region which originate from pituicytes which are specialised glial cells of neurohypophysis and infundibulum.Case report: A 63-year-old lady with a background history of bilateral cataract corrected with surge...