Endocrine Abstracts

Thyroid cancer (TC) has one of the fastest increasing incidences worldwide and primarily involves papillary thyroid cancer (PTC). Cancer cells have numerous mechanisms that govern drug resistance, among which activation of multidrug resistance (MDR) genes encoding ABC efflux pumps plays an important role. Acquisition of drug resistance by TC cells is becoming a significant obstacle to effective therapy, leading to insensitivity to classical chemotherapeutics, but also to speci...

Introduction: Medullary thyroid carcinoma (MTC) constitutes 3.5-5% of all thyroid cancers. Routine biochemical diagnostics include determination of calcitonin (CT), procalcitonin (PCT) and carcinoembryonic antigen (CEA). XIAP (X-linked inhibitor of apoptosis protein) and survivin belong to the family of proteins – inhibitors of apoptosis (IAP). Using tissue microarrays, the expression levels of XIAP and survivin were tested in patients with medullary thyroid cancer. The s...