ea0056gp116 | Diabetes Translational | ECE2018
Taxeras Siri
, Piquer-Garcia Irene
, Pellitero Silvia
, Puig Rocio
, Martinez Eva
, Tarasco Jordi
, Moreno Pau
, Bombuy Ernest
, Higueras Carmen
, Malagon Paloma
, Lerin Carles
, Puig-Domingo Manel
, Sanchez-Infantes David
Background: Obesity can lead type 2 diabetes (T2D), however there are patients with obesity who present euglycemia. The mechanisms by which T2D appears have not been fully elucidated. Oncostatin m (OSM) is a proinflammatory cytokine, member of the IL-6 family, which is increased in obesity in mice and humans, and impairs browning in mice. Here, we aim at evaluating the potential role of OSM in the development of T2D in patients with obesity.Material and ...