Searchable abstracts of presentations at key conferences in endocrinology

ea0041oc13.1 | Pituitary Clinical | ECE2016

Acromegaly is associated with increased cancer risk: a nationwide survey in Italy on behalf of the Italian study group of acromegaly

Reimondo Giuseppe , Terzolo Massimo , Berchialla Paola , Malchiodi Elena , Arosio Maura

Introduction: That acromegaly may cause cancer remains an unsolved issue. Aim of the present study was to assess the standardized incidence ratios (SIRs) of different types of cancer in a nationwide multicenter cohort study in Italy on acromegalic patients who have been treated in the somatostatin-receptor ligands era.Methods and design: We have evaluated the prevalence of neoplasia from a series of 1512 patients who were proactively followed in 24 terti...

ea0037ep806 | Pituitary: clinical | ECE2015

Psychological and neurocognitive evaluation in patients with pituitary adenoma

Sala Elisa , Zarino Barbara , Malchiodi Elena , Verrua Elisa , Carosi Giulia , Locatelli Marco , Rampini Paolo , Carrabba Giorgio , Spada Anna , Mantovani Giovanna

Reduced health-related quality of life (HRQoL) and impairment in neurocognitive functions are a possible complaint in patients with pituitary adenoma. Psychiatric comorbidities in Cushing’s disease are well known. However recent studies showed HRQoL reduction and psychiatric symptoms in patients with pituitary disease with or without hormonal excess. Aim of this study is to analyse HRQoL, psychiatric symptoms and neurocognitive functions in patients with pituitary adenoma...

ea0035p845 | Pituitary Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2014

NFPA and hypopituitarism: a retrospective analysis of 260 patients and focus on the prevalence of isolated hypoadrenalism

Carosi Giulia , Malchiodi Elena , Ferrante Emanuele , Sala Elisa , Verrua Elisa , Beck-Peccoz Paolo , Spada Anna , Mantovani Giovanna

Introduction: Non-functioning pituitary adenomas (NFPA) accounts for about 40% of all pituitary tumors. One or more anteropituitary deficiencies are present at diagnosis in 60–80% of NFPA. Hypopituitarism classically appears with the following order: GH→FSH/LH→TSH→ACTH. Aim of the study was to evaluate the incidence and the order of appearance of pituitary deficiencies in patients with NFPA.Materials and methods: We retrospectively...

ea0022p620 | Neuroendocrinology and Pituitary (<emphasis role="italic">Generously supported by Novartis</emphasis>) | ECE2010

Epidemiology of acromegaly in Italy

Malchiodi Elena , Arosio Maura , Borraccino Alberto , Reimondo Giuseppe , Zaggia Barbara , Montefusco Laura , Maria Colao Anna , Terzolo Massimo

Aim of this study is to present preliminary epidemiological data on a population of 1512 acromegalic patients attending 22 tertiary centers in Italy from 1980 to 2002. At our knowledge this is the first large–scale epidemiological Italian study on acromegaly. Gender was 624 (41.2%) men and 888 (58.8%) women. Mean age at diagnosis was 45±13 years, 43±13 for men and 47±13 for women. Median estimated duration of acromegaly before diagnosis was 74 months (range...

ea0049ep1043 | Pituitary - Clinical | ECE2017

Salivary and serum cortisol levels by liquid chromatography tandem mass spectrometry after standard dose ACTH test in the diagnosis of central hypopituitarism

Morelli Valentina , Polledri Elisa , Mercadante Rosa , Sonzogni Beatrice , Mantovani Giovanna , Palmieri Serena , Malchiodi Elena , Verrua Elisa , Barbieri Anna Maria , Ferrante Emanuele , Arosio Maura , Fustinoni Silvia , Chiodini Iacopo

Objective: The diagnosis of central hypoadrenalism (HPAI) is a major clinical challenge. The gold standard procedure remains insuline tolerance test (ITT). Liquid chromatography tandem mass spectrometry (LC-MS/MS) is considered the best procedure for the evaluation of cortisol levels. This study aimed to evaluate cut-offs of serum (TM-SeC) and salivary cortisol (SaC) by LC-MS/MS and serum cortisol by ECLIA assay (E-SeC) after Standard dose ACTH test (SDCT) in diagnosing HPAI.<...

ea0037gp.19.02 | Pituitary–Acromegaly | ECE2015

Assessment of bone quality, measured by trabecular bone score, in acromegaly

Malchiodi Elena , Sala Elisa , Verrua Elisa , Cairoli Elisa , Carosi Giulia , Ferrante Emanuele , Filopanti Marcello , Ulivieri Fabio Massimo , Eller-Vainicher Cristina , Chiodini Iacopo , Mantovani Giovanna , Spada Anna

Introduction: Acromegaly is characterised by chronic exposure to high GH and IGF1 levels that leads to increased bone turnover. Regardless of BMD value, acromegalic patients seem to have an increased vertebral fracture risk probably due to a reduction of bone quality. Trabecular bone score (TBS) is a new index used for assessing bone microarchitecture. In this study TBS was used for the first time to analyze bone quality in acromegaly.Methods: 16 new acr...

ea0035p898 | Pituitary Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2014

Recurrence of hyperprolactinemia after withdrawal of cabergoline in prolactinomas

Sala Elisa , Bellaviti Paola , Ferrante Emanuele , Malchiodi Elena , Verrua Elisa , Giavoli Claudia , Profka Eriselda , Beck-Peccoz Paolo , Spada Anna , Mantovani Giovanna

Introduction: The optimal treatment duration for prolactinomas to minimize reccurences is not clear. 2011 Endocrine Society Guidelines suggested that cabergoline withdrawal may be safely undertaken after 2 years in patients achieving normoprolactinemia and tumor volume reduction.Materials and methods: We analyzed 74 patients (mean age=46.9±14.4, M/F=19/56, macro/micro=18/56) bearing a prolactinoma. Patients were divided in 3 groups: Group A (23) tre...

ea0032p861 | Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

Incidentally discovered pituitary adenomas: single-center experience on 205 patients

Malchiodi Elena , Ferrante Emanuele , Mantovani Giovanna , Toini Alessandra , Sala Elisa , Verrua Elisa , Giavoli Claudia , Filopanti Marcello , Spada Anna , Beck-Peccoz Paolo

Introduction: Pituitary incidentalomas are lesions discovered on an imaging study performed for an unrelated reason. Their frequency varies among 0.2–38% and it is continuously increasing due to the development of neuroimaging techniques. The aim of the study is to investigate clinical and biochemical characteristics of 205 consecutive patients (70% female, mean age 53.6±18.2 years) with incidental pituitary adenoma (IPA) followed at our center from 1990 to present.<...

ea0032p878 | Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

Role of IGF(CA)19 gene polymorphism in the clinical presentation of acromegaly

Sala Elisa , Mantovani Giovanna , Ferrante Emanuele , Barbieri Anna Maria , Malchiodi Elena , Verrua Elisa , Giavoli Claudia , Filopanti Marcello , Beck-Peccoz Paolo , Spada Anna

Introduction: A highly polymorphic microsatellite, comprising a variable length of a cytosine–adenosine (CA) repeat sequence, has been identified in the promoter region of IGF-I gene. The number of CA repeats ranges between 10 and 24 and the most common allele in the Caucasian population contains 19 CA (192 bp) repeats. Several studies investigated the relationship between this polymorphism and IGF-I levels, with conflicting results. Aim of this study was to investigate t...

ea0032p932 | Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

Diagnostic features and surgical therapy of acromegalic patients: experience of the last three decades

Ferrante Emanuele , Sala Elisa , Locatelli Marco , Mantovani Giovanna , Malchiodi Elena , Carrabba Giorgio , Gaini Sergio Maria , Lania Andrea Gerardo , Spada Anna , Beck-Peccoz Paolo

Introduction: Generously supported by IPSEN)-->Acromegaly is a rare and insidious disease associated with an increased morbidity and mortality. Trans-sphenoidal (TNS) surgery remains the primary therapeutic option, in particular for intrasellar microadenomas and noninvasive macroadenomas. Aims of this study were to describe diagnostic features and to verify the impact of TNS surgery on treatment of acromegaly over three decades, befo...