Searchable abstracts of presentations at key conferences in endocrinology

ea0095oc9.6 | Oral Communications 9 | BSPED2023

How does HbA1c compare with OGTT in identifying patients with Diabetes Mellitus and Pre-Diabetes

Sims Jack , Worth Chris , Manfredonia Claire , Ginbey Eleanor , Skae Mars

Introduction: The incidence of Type 2 Diabetes Mellitus (T2DM) is rapidly increasing within the paediatric community, prompting searches for a simple and effective screening tool. Oral glucose tolerance test (OGTT) is the gold standard but is poorly accessible in the community. HbA1c offers an alternative which can be easily performed, but cut-offs for children have been extrapolated directly from the adult American Diabetes Association (ADA) diagnostic criter...

ea0036P82 | (1) | BSPED2014

An audit to assess the impact of increasing the borderline blood spot TSH cut-off on the detection of cases of congenital hypothyroidism (CHT) identified via newborn screening

Tetlow Lesley , Ehtisham Sarah , Hird Beverly , Manfredonia Claire , Nice Daniella , Scargill Jonathan , Steele Caroline

Background: The UK Newborn Screening Programme Centre Clinical Referral Standards and Guidelines for CHT (2013) define TSH cut-offs for screen positive (>20 mU/l) and borderline (>10 and <20 mU/l) results. In Manchester levels >8 and <20 mU/l are classified as borderline. This audit aims to assess whether adopting the national cut-off would result in babies with significant and permanent hypothyroid disease being missed.Patient popula...

ea0058p023 | Growth | BSPED2018

Optimising diagnostic performance of IGF-I and IGFBP-3 measurement: importance of reference range and cut-off value

Al-Hashmi Laila , Manfredonia Claire , Banerjee Indi , Tetlow Lesley , Murray Philip , Clayton Peter

Background: The diagnosis of growth hormone deficiency (GHD) is based on a combination of clinical suspicion supported by growth hormone stimulation testing. IGF-1 and IGFBP-3 are used as supportive markers. Reports over the last decade have examined the performance of IGF-I and IGFBP-3 in the diagnosis of GHD. It is important that each unit evaluates the utility of these markers in the assay used by their laboratory based on relevant normative data.Aim:...