Endocrine Abstracts

Background: SEREN is an established, QISMET accredited structured education programme for children/young people (CYP) and their families with Type 1 diabetes mellitus (T1DM), developed in Wales. The first module ‘Diabetes at diagnosis’ has been in use in Wales since 2016. The resources and health care professional (HCP) training have also been used by some paediatric diabetes teams in England who have since embedded SEREN into their diabetes care. Th...

Objective: The EarLy Surveillance for Autoimmune diabetes (ELSA) study is screening 20,000 children aged 3-13 years for type 1 diabetes through measurement of islet autoantibodies. Screening aims to prevent diabetic ketoacidosis at clinical onset of disease and identifies the population who could benefit from prevention trials. The ELSA-1 study aimed to explore the perspectives of parents and stakeholders on the relative benefits and limitations of screening i...

Background: The National Paediatric Diabetes audit (NPDA) reports increasing number of children and young people with type 2 diabetes (CYP2D). CYP2D are less likely to receive all recommended health checks compared to those with type 1 diabetes (33% vs 59% respectively) and do not receive treatment for complications even when they are identified (T2D spotlight audit 2019/20). We assessed variation in care across different units against the national T2D guideli...

Technological advances in the management of TIDM are making a significant impact on optimising blood sugar level control and improving quality of life for children with diabetes. Locally, the impact of technological advances, rising caseload and static numbers of Paediatric Diabetes Specialist Nurses (PDSNs) has led to a significant reduction in the ‘time to care’ as large amounts of clinic time was consumed by connections to technology and downloading by the diabete...

Background: Hybrid closed loop (HCL) insulin systems are associated with better glycaemic control and reduced hypoglycaemia risk. They represent the most advanced form of insulin delivery for people with type 1 diabetes mellitus (T1DM).Aim: The study aimed to evaluate effectiveness of 3 HCL systems in children and young people (CYP) with T1DM at Nottingham Children’s Hospital.Methods:<...

Introduction: The incidence of Type 2 Diabetes Mellitus (T2DM) is rapidly increasing within the paediatric community, prompting searches for a simple and effective screening tool. Oral glucose tolerance test (OGTT) is the gold standard but is poorly accessible in the community. HbA1c offers an alternative which can be easily performed, but cut-offs for children have been extrapolated directly from the adult American Diabetes Association (ADA) diagnostic criter...

Introduction: The International Society for Paediatric and Adolescent Diabetes (ISPAD) 2022 Nutritional Guidelines recommend calculating carbohydrate requirements using an indivualised equation, such as the Schofield equation. Up to 2023, our centre used the Scientific Advisory Committee on Nutrition (SACN) 2011 guidelines that only require age to determine average carbohydrate requirements. The latest National Paediatric Diabetes Audit (NPDA) showed our centr...

CFTR modulators are drugs that enhance/restore the expression, function, or stabilize the defective CFTR protein in patients with cystic fibrosis (CF). These modulators have shown marked improvements in lung function and quality of life for people with CF but their role in glucose tolerance is still unclear1. At Nottingham Children’s Hospital, children with CF are eligible for kaftrio treatment (Elexacaftor/tezacaftor/ivacaftor CFTR modulator) from 10 years of ...

Background: From 2018 to 2020, the Birmingham Children’s Hospital (BCH) Diabetes Team was a negative regional outlier for the National Paediatric Diabetes Audit (NPDA) seven key care processes. In 2021, the BCH team embarked on a Quality Improvement (QI) journey using Plan-Do-Study-Act (PDSA) cycles to improve care.Objective: Review PDSA cycles of improvements from 2021 to 2023.Methods...