Searchable abstracts of presentations at key conferences in endocrinology
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50th Annual Meeting of the British Society for Paediatric Endocrinology and Diabetes

Manchester, UK
08 Nov 2023 - 10 Nov 2023

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The 50th Annual BSPED Meeting will take place at the Midland Hotel, Manchester from 8-10 November 2023.

Oral Communications

Oral Communications 8

ea0095oc8.1 | Oral Communications 8 | BSPED2023

Is there reversal of virilisation after commencing medical replacement therapy for 46XX classical congenital adrenal hyperplasia (CAH)?

Hennayake Supul , Goyal Anju , Patel Leena

Genitalia appear larger and swollen in all neonates due to the circulating maternal hormones and this subsides spontaneously over few weeks or months. Additionally, general growth of the rest of the body outpaces any growth of the genitalia during childhood, resulting in apparent reduction in the size of the genitalia comparatively. There are high levels of circulating androgens in children with CAH until the commencement of medical replacement therapy (MRT). It is universally...

ea0095oc8.2 | Oral Communications 8 | BSPED2023

Rare variants in the MECP2 gene in girls with central precocious puberty

Read Jordan , Guasti Leonardo , Paganoni Alyssa , Howard Sasha

Key genetic contributors are recognised to underlie the phenotype of central precocious puberty (CPP), including the imprinted genes Makorin ring finger protein 3 (MKRN3) and Delta-like homolog 1 (DLK1), alongside Kisspeptin-1 (KISS1) and (KISSR1). These genes have implicated mis-regulation of transcriptional control of the kisspeptin and gonadotropin-releasing hormone (GnRH) neuroendocrine systems in onset of CPP. However, many familial cases of CPP remain without clear a gen...

ea0095oc8.3 | Oral Communications 8 | BSPED2023

Dysregulated pathways reveal NOVEL mechanistic insights underlying HMGA2-related growth failure in Silver Russell Syndrome

Maharaj Avinaash , Cottrell Emily , Massoud Ahmed , Hwa Vivian , Storr Helen

Background: Silver Russell syndrome (SRS) is a heterogeneous disorder characterised by intrauterine and post-natal growth retardation, relative macrocephaly, protruding forehead, feeding difficulties and body asymmetry. Variants in HMGA2 are a rare cause of SRS and despite strong evidence for the crucial role of HMGA2 in growth regulation, the underlying mechanism underlying growth retardation has, thus far, not been elucidated....

ea0095oc8.5 | Oral Communications 8 | BSPED2023

Feasibility of integrating an exercise specialist supported by mHealth technology to increase exercise and physical activity in an adolescent Complications from Excess Weight Service: MOTIVATE-CEW

Davies Andrew , Hesketh Katie , Clarke Ellie , Apperley Louise , Sprung Victoria , Jones Helen , Kinnafick Florence , Senniappan Senthil , Cocks Matthew

NHS England has established several Complications from Excess Weight (CEW) services. Despite physical activity (PA) being an integral part of successful weight management programmes, the capacity to offer an effective PA program within CEW services could be limited by resources. The aim of the study was to assess the feasibility of embedding an exercise specialist led, mobile health (mHealth) technology supported, PA and exercise intervention (MOTIVATE-CEW) to a CEW service. A...