ea0020p54 | Adrenal | ECE2009
Mangoni Monica
, Gelmini Stefania
, Nesi Gabriella
, Poli Giada
, Cantini Giulia
, Lombardi Adriana
, Orlando Claudio
, Serio Mario
, Mannelli Massimo
, Luconi Michaela
Adrenocortical carcinoma (ACC) is a rare and aggressive tumour with a poor prognosis, characterized by radio/chemotherapy resistance. The lack of an effective medical treatment is due to the poor knowledge of the mechanisms underlying malignant tumour transformation and aggressiveness. In vitro studies on the ACC H295R cell model have demonstrated that RGZ, an antidiabetic drug belonging to the thiazolidinedione ligands of PPARgamma, blocks cell proliferation/migration ...