Searchable abstracts of presentations at key conferences in endocrinology
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11th European Congress of Endocrinology

ea0020p1 | Adrenal | ECE2009

Hematoma: unusual presentation of adrenal masses

Vieira Alexandra , Baptista Carla , Paiva Isabel , Barros Luisa , Santos Jacinta , Martinho Mariana , Carrilho Francisco , Carvalheiro Manuela

Introduction: Adrenal hematomas are very rare entities. They occur often associated with: trauma, anticoagulation, coagulopathy, septicemia, pregnancy complications or tumors. When none of these predisposing factors is present, diagnosis and treatment can become a real challenge.Case report: A 19-years-old woman presented with complaints of asteny, loss of appetite, loss of 10 kg in a month, and pain in right lumbar and abdominal regions. No other compla...

ea0020p2 | Adrenal | ECE2009

Von-Hippel Lindau disease and pheochromocytoma – case report

Daniel Silva Vaz J , Queiroz E , Lima Jorge Dores

Aims: VHL disease is an autossomal dominant syndrome that affects one in every 36 000 live births. The diagnosis is based on clinical criteria and the detection of the mutation on VHL gene. Most cases are diagnosed during the 2nd decade of life; this syndrome includes pheochromocytomas with the following characteristics: extraadrenal location, bilaterality, multifocal lesions, age of onset <30 years and discrete manifestations of catecholamine overproduction.<p class="...

ea0020p3 | Adrenal | ECE2009

Effect of dietary protein on post-prandial salivary cortisol and androgen levels in healthy women volunteers

Lyles Alison , Al-Dujaili Emad

Objective: Macronutrients such as protein and fat have been postulated to elicit post-prandial effects upon cortisol and testosterone concentrations. This pilot study was conducted to test the hypothesis that a meal high in protein content can elicit a positive effect on post-prandial cortisol levels whilst producing a negative effect on DHEA and testosterone levels. Methods: In 13 healthy female volunteers (aged between 19–29 years; BMI ranged from...

ea0020p4 | Adrenal | ECE2009

Correlation between development of testicular adrenal rest tumors and genotype in children, adolescents and adult males with congenital adrenal hyperplasia

Mouritsen Annette , Jorgensen Niels , Main Katharina M , Schwartz Marianne , Juul Anders

Background: Previous studies have demonstrated a high overall prevalence of testicular adrenal rest tumors (TART) in adults with congenital adrenal hyperplasia (CAH), whereas little is known about the prevalence in children. The aim of this study was to determine the presence of TART according to age and genotype.Design: Retrospective study, tertiary University centre.Patients and methods: In 47 male patients (age 2.6–40.3 yea...

ea0020p5 | Adrenal | ECE2009

Abstract withdrawn....

ea0020p6 | Adrenal | ECE2009

Unbiased stereological study of silymarin effects on adrenocortical structure of dexamethasone treated hamsters

Hamidian Gholamreza , Alboghobeish Naeem , Najafzadeh Varzi Hossein , Esmaeilzadeh Saleh

Adrenal cortex is an essential portion for life and its function can be affected by many chemical agents and drugs. This study was to investigate effect of silymarin, a flavonoid, on adrenocortical structure of male dexamethasone treated hamsters.In this study, 20 young adult male golden hamsters were randomly allocated to four groups: control group which received no drug; group two which received 7 mg/kg dexamethasone; group three which received 100 mg/...

ea0020p7 | Adrenal | ECE2009

Use of diurnal rhythm in salivary aldosterone to discriminate between bilateral adrenal hyperplasia and aldosterone producing adenoma

Manolopoulou Jenny , Gerum Sabine , Mulatero Paolo , Spyroglou Ariadni , Reincke Martin , Bidlingmaier Martin

Differential diagnosis between bilateral adrenal hyperplasia (BAH) and aldosterone producing adenoma (APA) in aldosteronism remains challenging in many cases due to the high prevalence of incidentalomas during imaging techniques, the limited sensitivity of orthostatic testing and the technical difficulties of adrenal vein sampling (AVS).We investigated circadian variation in salivary aldosterone (SA) in patients with APA (n=22) and BAH (n=2...

ea0020p8 | Adrenal | ECE2009

Effect of universal somatostatin analog (SOM230) on primary adrenal cell cultures

Mariniello Barbara , Finco Isabella , Rubin Beatrice , Patalano Anna , Ferasin Sergio , Iacobone Maurizio , Fassina Ambrogio , Mantero Franco

Introduction: Somatostatin (SST) is a widely distributed polypeptide that modulates the endocrine and exocrine secretion, cellular proliferation and differentiation, and apoptosis via G protein-linked receptors. Our previous studies showed high SSTR expression in adrenocortical carcinoma (ACC), aldosterone producing adenoma (APA) and in cortisol producing adenoma (CPA). Only very few information are available about the effectiveness of SST analogs in adrenal tumors.<p clas...

ea0020p9 | Adrenal | ECE2009

Replicating the normal cortisol circadian rhythm using a formulation of modified-release hydrocortisone

Debono Miguel , Ghobadi Cyrus , Rostami-Hodjegan Amin , Huatan Hiep , Campbell Mike , Newell-Price John , Darzy Ken , Merke DeborahP , Arlt Wiebke , Ross Richard

Background: The adrenal glucocorticoid, cortisol, has a distinct circadian rhythm regulated by the brain’s central pacemaker. This cortisol rhythm acts as a secondary messenger to peripheral tissues and loss of the rhythm is associated with increased morbidity and mortality. This is a specific problem in adrenal insufficiency and congenital adrenal hyperplasia (CAH). Based on pharmacokinetic modelling we have developed a modified-release formulation of hydrocortisone (MR-...

ea0020p10 | Adrenal | ECE2009

The cortisone to cortisol conversion in autoimmune Type 1 diabetes

Simunkova Katerina , Kriz Lubomir , Hill Martin , Vrbikova Jana , Hampl Richard , Zamrazil Vaclav , Janickova Denisa , Vondra Karel

The aim of the study was to obtain data about peripheral metabolism of cortisol.We compared diabetics with low response (LR), and with normal response (NR) during low dose ACTH test, and a control group (C).Twelve diabetics were investigated; LR (n=6), NR (n=6), age 44±10 year (mean±S.D.), age at diagnosis of DM1 28.5±10 year, disease duration 15±8 year, BMI 24.5±2.7 kg/cm2...

ea0020p11 | Adrenal | ECE2009

Are there some alterations of salivary cortisol dynamics in obese patients?

Jelic Svetlana , Caparevic Zorica , Ilic Sanja , Marina Djordje

The metabolic syndrome resembles Cushing’s syndrome in several clinical aspects. Main characteristic of both syndromes is obesity assessed by the body mass index (BMI) or waist circumference (WC).The aim of this study was to investigate cortisol dynamics in 20 healthy volunteers (BMI<27 kg/m2; 13 females, 7 males, age 42.1+12.39 years) and 20 obese patients (BMI≥27 kg/m2; 13 females, 7 males, age 49.25+1...

ea0020p12 | Adrenal | ECE2009

Short term regulation of aldosterone secretion after stimulation and suppression experiments in mice

Spyroglou Ariadni , Manolopoulou Jenny , Reincke Martin , Bidlingmaier Martin , Beuschlein Felix

Aldosterone is synthesized acutely upon stimulation of the renin-angiotensin-aldosterone system from the cells of the zona glomerulosa. Several enzymes are involved in this steroidogenic process including the steroidogenic acute regulatory protein (StAR), P450 side chain cleavage enzyme (Cyp11a1) and aldosterone synthase, the product of the gene Cyp11b2.We investigated the short time transcriptional regulation of these genes in wild type mi...

ea0020p13 | Adrenal | ECE2009

Autoimmune adrenal insufficiency: Addison's disease versus idiopathic isolated secondary adrenal insufficiency

Kasperlik-Zaluska Anna , Czarnocka Barbara , Jeske Wojciech , Papierska Lucyna , Hulting Anna-Lena , Bensing Sophie , Crock Patricia , Kampe Olle

Studies on autoimmune Addison’s disease (AD) have a long tradition, while knowledge on idiopathic isolated secondary adrenal insufficiency (SAI), which also seems to be caused by autoimmunity, is not so popular. Our presentation aimed at comparing two groups of patients: 1) 238 patients with AD (183 women, F/M=4.3), aged 8–61 years at time of diagnosis and 2) 301 patients with SAI (269 women, F/M=8.4), aged 17–87 years at time of diagnosis. Maximum time of durat...

ea0020p14 | Adrenal | ECE2009

Prediction of metabolic syndrome by low serum testosterone levels in men: results from the Study of Health in Pomerania

Haring Robin , Volzke Henry , Felix Stephan B , Schipf Sabine , Dorr Marcus , Rosskopf Dieter , Nauck Matthias , Schofl Christof , Wallaschofski Henri

Aim: The aim of this analysis was to determine whether low serum testosterone (T) and dehydroepiandrosterone sulfate (DHEAS) levels predict the development of metabolic syndrome (MetS) in men.Methods: Data were obtained from the Study of Health in Pomerania (SHIP), a population-based prospective cohort of adults aged 20–79 at baseline. Analyses were conducted in 1004 men without baseline MetS, defined by National Cholesterol Education Program Adult ...

ea0020p15 | Adrenal | ECE2009

Prediction of fatal stroke by high serum aldosterone levels

Tomaschitz Andreas , Pilz Stefan , Dobnig Harald , Winkelmann Bernhard R , Renner Wilfried , Boehm Bernhard O , Maerz Winfried

Background: There is increasing evidence that aldosterone exerts deleterious, blood pressure independent effects on cerebral blood vessels. We aimed to evaluate whether high aldosterone levels are related to fatal stroke.Methods: Serum aldosterone concentrations (SAC, pg/ml) were measured in 3073 Caucasian patients, who were routinely referred to coronary angiography. We calculated Cox proportional hazard ratios for death due to fatal stroke according to...

ea0020p16 | Adrenal | ECE2009

Effects of castration and testosterone treatment on adrenal activity of a saharan gerbil, Meriones libycus in breeding and non breeding season

Aknoun Nawel , Zatra Yamina , Khammar Farida , Amirat Zaina

In the Saharan gerbil Meriones libycus, live trapped in the south west of Algeria, castration, carried out during the breeding season (Winter–Spring), induced, 50 days later, important modifications in adrenal gland activity. The adrenal weight and cortex volume increased by 11.7% and 25.0% respectively, with hypertrophy of reticularis zona (+57%, P<0.001) and hypotrophy of fasciculata zona (−13.4%, P<0.001) while glomerulosa exhibited o...

ea0020p17 | Adrenal | ECE2009

Gitelman syndrome: clinical presentation and genetic analysis of 27 patients with hypokalemia caused by renal potassium wasting

Balavoine Anne-Sophie , Bataille Pierre , Vanhille Philippe , Azar Raymond , Glowacki Francois , Vargas-Poussou Rosa , Jeunemaitre Xavier , Wemeau Jean-Louis , Vantyghem Marie-Christine

Gitelman syndrome (GS) is a recessive salt loosing tubulopathy caused by mutations in the SLC12A3 gene encoding the thiazide-sensitive Na+-Cl− cotransporter, and characterized by secondary hyperaldosteronism, hypokalemic alkalosis, hypomagnesemia and hypocalciuria.The aim: Of the work was to investigate 27 adult patients with hypokalemia due to renal potassium wasting after exclusion of diuretics abuse, vomiting or diar...

ea0020p18 | Adrenal | ECE2009

Bilateral adrenal incidentalomas – a clinical study of 1710 patients observed at a single endocrinological centre

Kasperllik-Zaluska Anna , Slowinska-Srzednicka Jadwiga , Roslonowska Elzbieta , Kochman Magdalena , Zgliczynski Wojciech , Jeske Wojciech , Otto Maciej , Cichocki Andrzej

In the last 18 years 1710 patients with incidentally found adrenal tumours=adrenal incidentalomas (AI), 1300 women (F/M=2.8), aged 10–87 years, were registered at our department. In 338 of them (20%) bilateral tumours were detected. This study aimed at analyzing character of bilateral tumours and defining methods of their management. The size: 1.0–13 cm (in the group of 1710 patients: 1.0–23 cm) most of them up to 3.5 cm. Hormonal and imaging studies were perfor...

ea0020p19 | Adrenal | ECE2009

Adipokine levels in patients with adrenal incidentaloma

Iorio Laura , Morelli Valentina , Coletti Francesca , Della Casa Sonia , Arosio Maura , Corsi Massimiliano , Chiodini Iacopo , Ambrosi Bruno

Patients (pts) with adrenal incidentaloma (AI) may show an increased incidence of several cardiovascular risk factors, as obesity, hypertension, diabetes mellitus and dyslipidemia. As previous data suggested that the increased cardiovascular risk in these pts could be in part mediated by alterations of adipokines, this study was aimed to evaluate plasma IL-6, resistin, CT-1 levels in a wide series of pts with AI.Ninety-three pts (42 males; 51 females; ag...

ea0020p20 | Adrenal | ECE2009

Chemokine receptor expression in the adrenal cortex and in adrenocortical tumours

Lang Katharina , Sturmer Andrea , Adam Patrick , Fassnacht Martin , Quinkler Marcus , Morcos Michael , Allolio Bruno , Hahner Stefanie

Introduction: Chemokines and their receptors (CR) have been demonstrated to be involved in tumour growth and site specific metastasis. Furthermore, several cytokines have been described to modulate adrenocortical function. Therefore, we have investigated the expression pattern and functional activity of chemokine receptors and of corresponding chemokines in adrenocortical tissue.Methods: Chemokine and CR expression was assessed by RT-PCR in normal adrena...

ea0020p21 | Adrenal | ECE2009

Bilateral macronodular adrenal hyperplasia versus bilateral micronodular adrenal hyperplasia

Kebapci Nur , Efe Belgin , Kebapci Mahmut

Bilateral macronodular or micronodular adrenal hyperplasias are related to ACTH-independent or ACTH-dependant pathologies. ACTH-independent bilateral macronodular adrenal hyperplasia (AIMAH) and primary pigmented adrenocortical disease (PPNAD) are classical but rare examples of ACTH-independent pathologies, causing Cushing Syndrome. PPNAD is presented as bilateral micronodular adrenal hyperplasia.On the other hand, inherited defects in the enzymatic step...

ea0020p22 | Adrenal | ECE2009

Role of chemokines MIP1α and MIP1β in patients with Addison's disease isolated or associated to autoimmune thyroid disease

De Bellis Annamaria , Pane Elena , Battaglia Marina , Ruocco Giuseppe , Tirelli Gilda , Bellastella Giuseppe , Agostino Sinisi Antonio , Susan Costantini , Capone Francesca , Aiello Talamanca Annarita , Calemma Rosa , Bizzarro Antonio , Bellastella Antonio

High levels of macrophage inflammatory proteins (MIP1α and MIP1β), related to the recruitment of Th1 and Th2 cells, respectively, have been evidenced in some organ and non organ-specific autoimmune diseases. CXCL10/IP10 has been evidenced in patients with autoimmune thyroid disease (ATD) and in Addison’s disease (AD); MIP1α and MIP1β chemokines have not been so far evaluated in these diseases.Aim: To evaluate plasmatic levels MIP...

ea0020p23 | Adrenal | ECE2009

IL-6 and osteoprotogerin levels in subjects with non-functioning adrenal adenomas

Yener Serkan , Comlekci Abdurrahman , Yuksel Faize , Comlekci Abdurrahman , Akinci Baris , Demir Tevfik , Yesil Sena

Data regarding cardiovascular risk in subjects with non-functioning adrenal adenoma is limited. The aim of this study is to investigate osteoprotogerin (OPG) and Interleukin-6 (IL-6) levels in subjects with non functioning adrenal incidentalomas.Of 51 subjects without findings of hypercortisolism or other adrenal gland disorders (AI), 32 BMI-unmatched controls (C) and 20 BMI-matched controls (BC) were enrolled. Participants underwent hormonal evaluation ...

ea0020p24 | Adrenal | ECE2009

Characterization of tyrosine hydroxylase expression in various adrenal tumors to confirm the diagnosis of adrenal pheochromocytomas

Ueberberg Bianca , Hinrichs Jakob , Walz Martin K , Schmid Kurt W , Mann Klaus , Petersenn Stephan

Background: Tyrosine hydroxylase (TH) is the first enzyme in the pathway of catecholamine synthesis catalyzing the conversion of tyrosine to dihydroxyphenylalanine (DOPA). To establish a molecular marker for adrenal pheochromocytomas, we compared the expression in various adrenal tumors in comparison to normal adrenal glands.Methods: Tissue from 19 pheochromocytomas (PHEO), 20 aldosterone-producing adenomas (APA), 20 cortisol-producing adenomas (CPA), an...

ea0020p25 | Adrenal | ECE2009

Towards an aldosterone producing cell line from an aldosterone producing adenoma

Lichtenauer Urs , Zwermann Oliver , Shapiro Igor , Mussack Thomas , Reincke Martin , Beuschlein Felix

To date, the in depth analysis of the key molecular mechanisms involved in functional autonomy and tumor formation in aldosterone producing adenomas has been hampered by the rarity of the disease and the lack of adequate tumor cell lines. Herein, we cultivated a primary cell culture of an aldosterone producing adenoma taken from a 40 year old male patient with a left sided adrenal tumor mass. The cells have been passaged 24 times and still continue to grow after nearly 11 mont...

ea0020p26 | Adrenal | ECE2009

Cardiac structure and function in patients with adrenal incidentaloma: an echocardiographic study

De Leo Monica , Galderisi Maurizio , De Martino Maria Cristina , Cozzolino Alessia , Colao Annamaria , Pivonello Rosario , Lombardi Gaetano

Subclinical Cushing’s syndrome (SCS) is a mild autonomous cortisol hypersecretion without specific clinical syndrome of glucocorticoid excess. The aim of this study was to compare cardiac structure and function in patients with adrenal incidentaloma. Twenty patients and 20 sex- and age-matched healthy controls entered the study: among patients, 11 had SCS and the remaining nine had normal cortisol secretion All patients and controls were submitted to Doppler echocardiogra...

ea0020p27 | Adrenal | ECE2009

Autoantibody screening of autoimmune gastrointestinal disorders in patients with autoimmune Addison disease

Kentos Peter , Pura Mikulas , Vanuga Peter

Backrgound: Coexistent gastrointestinal pathology might alter hydrocortisone (HCT) and levothyroxine (LT4) absorption and gut transit times.Aims: To screen patients with autoimmune Addison disease for the presence of serological markers of autoimmune gastrointestinal disorders, to compare doses of HCT and LT4 in patients with positive autoantibodies to those of patients without signs of autoimmune gastroenteropathy.Subjects and met...

ea0020p28 | Adrenal | ECE2009

Prior dexamethasone suppression test predicts development of adrenal insufficiency after a 14 days’ course of oral prednisone in healthy male volunteers

Neidert Stefanie , Schuetz Philipp , Mueller Beat , Christ-Crain Mirjam

Background: Neither dosage nor duration of systemic glucocorticoid therapy are reliable indicators of subsequent adrenal insufficiency. The dexamethasone suppression test is a measure of feedback sensitivity of the hypothalamic–pituitary–adrenal axis to cortisol. We hypothesized that this test predicts the later development of an adrenal insufficiency after a 14 days’ course of oral prednisone in healthy volunteers.Methods: We analyzed dat...

ea0020p29 | Adrenal | ECE2009

Glucocorticoid replacement therapy in adrenocortical insufficiency

Carli Anna Rita , Frigato Gemma , Bondanelli Marta , Zatelli Maria Chiara , Ambrosio Maria Rosaria , de gli Uberti Ettore

The effectiveness of glucocorticoid replacement therapy is based on clinical criteria, since objectives parameters are not standardized. The purpose of our study was to assess the adequacy of replacement therapy with cortisone acetate, trying to identify parameters indicating proper replacement. We studied 22 patients with adrenal insufficiency (7 primary and 15 secondary) treated with cortisone acetate (mean daily dose 36.5+/−2.1 mg at 0800 a.m. and 0300 p.m.), and six ...

ea0020p30 | Adrenal | ECE2009

Study of hormonal activity and insulin resistance in patients harbouring incidentally discovered bilateral adrenal adenomas

Androulakis Ioannis , Papanastasiou Lambrini , Tsenilklidi Ermioni , Prevoli Anastasia , Kafritsa Paraskevi , Pappa Theodora , Tsiavos Vaios , Piaditis George

Background: Hormonal activity and insulin resistance (IR) in patients with incidentally discovered bilateral adrenal adenomas (BA) has not been evaluated until now. Therefore, we have investigated cortisol and aldosterone secretion and IR in 29 patients with BA, in 113 patients with unilateral adrenal adenomas (UA) and in 89 healthy subjects (C).Methods: All subjects underwent the following investigation: 1) Low dose dexamethasone suppression test (LDDST...

ea0020p31 | Adrenal | ECE2009

Confounding variables for plasma metanephrines and normetanephrines may influence the diagnosis of pheochromocytomas

Deutschbein Timo , Jager Andrea , Mann Klaus , Petersenn Stephan

Introduction: Measurements of plasma metanephrines (META) and normetanephrines (NOR) have been advocated as first-line tests for the diagnosis of pheochromocytoma. This study assessed the impact of several potential confounders, which may influence the correct diagnosis.Methods: Eight healthy males (age 26.8±1.7; BMI 23.1±0.8) were tested on 6 separate days. Tests were performed in supine rest with blood sampling via i.v. canullas at 0900 h fol...

ea0020p32 | Adrenal | ECE2009

Is adrenal adenoma associated with the development of non-alcoholic fatty liver disease?

Yener Serkan , Ertilav Senem , Secil Mustafa , Akinci Baris , Demir Tevfik , Bayraktar Firat , Yesil Sena

It has been previously shown that adrenal adenomas are associated with a variety of metabolic disturbances like glucose intolerance and obesity. The aim of this study is to demonstrate the risk of non-alcoholic fatty liver disease development in subjects with adrenal incidentalomas.Among 302 subjects referred between 2001 and 2008 for the evaluation of incidentally discovered adrenal mass, 150 subjects with appropriate data were included. Computed tomogr...

ea0020p33 | Adrenal | ECE2009

A multi-institutional audit of laparoscopic adrenalectomy in Greece and the UK

Kekis Panagiotis , Markogiannakis Haridimos , Michalopoulos Nikolaos , Lagoudianakis Emmanuel , Fleming Bill , Martinez-Isla Alberto , Lynn John , Manouras Andreas

Objective: To evaluate the results of laparoscopic adrenalectomy in our institutions.Methods: Prospectively collected data from 2000 to 2007.Results: During the 8-year study period, 160 laparoscopic adrenalectomies were performed in 150 patients. Mean age was 49.8 years (female: 60.7%). Twenty-seven patients (18%) had previous open abdominal operations. There were 10 bilateral (6.6%) for Cushing’s disease, 64 right (42.7%) and...

ea0020p34 | Adrenal | ECE2009

The utility of the low dose dexamethasone suppression test in patients diagnosed with an adrenal incidentaloma

Debono Miguel , Durrington Charlotte , Williams Scott , Newell-Price John

Objective: The diagnosis of subclinical Cushing’s syndrome in patients with incidentalomas is not always straight forward and a number of different criteria have been used. The 1 mg overnight dexamethasone suppression test has been recommended as a screening test, followed up by other tests of the hypothalomo–pituitary–adrenal axis to confirm the diagnosis. In this study we investigate whether the low-dose dexamethasone suppression test offers additional informa...

ea0020p35 | Adrenal | ECE2009

Synacten test in patients with adrenal incidentaloma

Ivovic Miomira , Stojanovic Milos , Tancic-Gajic Milina , Marina Ljiljana , Vujovic Svetlana , Drezgic Milka

Considering that adrenal tumors are frequent in patients with congenital adrenal hyperplasia (82% in homozygote and 45% in heterozygote), Synacten test was at first introduced as marker of congenital adrenal deficiency in patient with adrenal incidentaloma. Recent studies showed normal and exaggerated cortisol response in more than 50% of patient with nonhypersecretory adrenal incidentaloma and more than 70% of patients with adrenal incidentaloma and subclinical hypercorticism...

ea0020p36 | Adrenal | ECE2009

Central ghrelin modulates morphology and function of adrenal cortex in male rats

Milosevic Verica , Sosic-Jurjevic Branka , Stevanovic Darko , Terzic Milica , Nesic Dejan , Starcevic Vesna , Sekulic Milka

Ghrelin is a growth hormone secretagogue that plays an important role in appetite and weight regulation. We have previously demonstrated that central ghrelin stimulated pituitary ACTH synthesis and secretion. In this study we further examined the effects of intracerebroventricular (ICV) ad-mi-nistration of ghrelin on zona glomerulosa (ZG), zona fasciculata (ZF) and zona reticularis (ZR) of the adrenal cortex, as well as the blood concentrations of aldosterone, corticosterone a...

ea0020p37 | Adrenal | ECE2009

Pheochromocytoma: a retrospective study on clinical presentation, management and outcomes

Martinho Mariana , Paiva Isabel , Carrilho Francisco , Fagulha Ana , Santos Jacinta , Vieira Alexandra , Rodrigues Fernando , Carvalheiro Manuela

Pheochromocytomas are rare, catecholamine-secreting, adrenal neoplasms. In about 25% of cases they arise in patients with germline mutations. Malignancy occurs in about 10%.We retrospectively analysed the records of patients with histological diagnosis of pheochromocytoma submitted to adrenal surgery between 1987–2008 and followed in the Endocrinology department.Thirteen patients were included. We evaluated age on diagnosis; c...

ea0020p38 | Adrenal | ECE2009

Epidemiological study of adrenal mass in our clinical centre

Novakovic-Paro Jovanka , Mitrovic Milena , Medic-Stojanoska Milica , Bajkin Ivana , Icin Tijana , Tomic Dusan , Vukovic Bojan , Kovacev-Zavisic Branka

Adrenal tumours form a very heterogeneous group by their origin, clinical presentation, size and biological potential.The aim of our retrospective study was the epidemiological analysis of the patients with adrenal tumours. We analyzed the gender, age, localisation, clinical presentation, and in patients who were treated surgically- the type of the intervention, patohystological and immunohystochemical finding from the 01.01.2000 to 01.01.2008. The linea...

ea0020p39 | Adrenal | ECE2009

Anemia in male patients with cushing’s syndrome before and after cure

Giraldi Francesca Pecori , Ascoli Paola , De Martin Martina , Polli Nicoletta , Cavagnini Francesco

Glucocorticoids are known to exert a stimulatory action on white blood cell precursor proliferation but little is known on erythrocyte counts in patients with Cushing’s syndrome.Aim: Of the present study was to assess red and white blood cell parametres in a large series of patients with Cushing’s syndrome and follow the blood cell changes after postsurgical remission or persistence of hypercortisolism.Methods: Of 84 pati...

ea0020p40 | Adrenal | ECE2009

Bilateral adrenal hemangioma cavernosum: NMI and a CT scanning as a complementary methods in newly detected degeneration in one gland

Tesic Dragan , Icin Tijana , Bogdanovic Dragana , Nikolic Olivera , djermanov Zoran , Budakov Pavle

Hemangiomas are the rare cases of adrenal incidentalomas, especially in their bilateral forms. Case study: male patient, 65 year, presented after the pain in right upper hemi abdomen, lasted half year. On ultrasonography there was an enlarged right suprarenal gland. Patient was on routine abdominal ultrasonography, with undetectable suprarenal glands, one year before. We concluded that something new happened in the meantime. On NMR the right suprarenal gland was 6.2×4.7 c...

ea0020p41 | Adrenal | ECE2009

Prospective evaluation of metabolic and anthropometric parameters in non-functioning adrenal adenomas

Yener Serkan , Ertilav Senem , Comlekci Abdurrahman , Secil Mustafa , Akinci Baris , Demir Tevfik , Yesil Sena

Adrenal adenomas are characterised with metabolic disturbances. The aim of this study is to demonstrate the changes in some metabolic and anthropometric parameters after 24 months follow up in subjects with non-functioning adrenal adenomas.Subjects referred between 2001 and 2008 for the evaluation of adrenal tumours were included. Computed tomography (CT) was the initial radiological intervention. Initial hormonal evaluation included 1 mg or 2 day 2 mg d...

ea0020p42 | Adrenal | ECE2009

Metastases of renal cell carcinoma to the adrenal glands: results of surgical treatment

Koloskov Vladimir , Britvin Timur , Polyakova Galina , Beloshitsky Mikhail , Kalinin Arian

Renal cell carcinoma metastases to adrenal glands are indicative of a generalized tumor process, but in cases of solitary metastases, a radical surgical treatment of these patients is possible.The object of the present study was an estimation of the remote outcome of surgical treatment of 18 patients with solitary renal cell carcinoma metastases to adrenal glands operated on in our clinic over the period from 1999 to 2008. Among them, there were 6 men an...

ea0020p43 | Adrenal | ECE2009

Iatrogenic Cushing’s syndrome induced by topical corticoid application in child and adult

Branisteanu Dumitru , Turliuc Serban , Veliaj Blenda , Mogos Simona , Zbranca Eusebie , Repede Ionut , Aancute Adrian , Mogos Voichita

Topical application of corticosteroids is frequently used in the therapy of dermatological diseases due to their anti-inflammatory and immunosuppressive effects. On the other hand, when reaching pharmacological levels, exogenous corticoids frequently lead to complete Cushing syndrome, including skin modifications, irrespective of the route of administration. We describe four cases of iatrogenic Cushing’s syndrome triggered by topical application of corticoids. The first t...

ea0020p44 | Adrenal | ECE2009

A rare cause of hyponatraemia presenting as acute adrenal insufficiency: bilateral adrenal haemorrhage

Gupta Saket , Hyde Sarah , Abbasi Babar , Thomas Sam , Hoashi Shu

We report a rare case of 37 years female of Greek and Irish extraction with a history of thalassemia trait, who presented with generalised weakness and severe loin and pelvic pain 9 days post vaginal hysterectomy and 3 days after hospital discharge. After readmission, she developed mild pyrexia (37.5°C), hypotension, mild hyponatraemia with plasma sodium which fell from 138 to 131 mM and early signs of acute respiratory distress syndrome. A Short Synacthen test was perfor...

ea0020p45 | Adrenal | ECE2009

Long-term follow-up of a 46XX patient with congenital lipoid adrenal hyperplasia due to a new mutation of the steroidogenic acute regulatory protein gene

Albarel Frederique , Simonin Gilbert , Morel Yves , Brue Thierry , Reynaud Rachel

Congenital lipoid adrenal hyperplasia (CLAH) is a severe disorder characterized by early impairment of both adrenal and gonadal steroidogenesis, leading to early adrenal failure and male sex reversal. The most common aetiology of CLAH is mutation of Steroidogenic acute regulatory protein (StAR) gene.Objective: We report evolution over 20 years of a 46XX patient harbouring a novel StAR gene mutation.Methods: Clinical, hormonal and i...

ea0020p46 | Adrenal | ECE2009

Insulin hypoglycemia test in the diagnosis of subclinical Cushing’s syndrome

Yener Ozturk Feyza , Erturk Erdinc , Guclu Metin , Kiyici Sinem , Unal Oguzkaan , Imamoglu Sazi

Although subclinical Cushing’s syndrome (SCS) is an important metabolic risk factor in patients with adrenal incidentaloma, the diagnostic criteria for SCS has not been established yet. The aim of this study was to evaluate the diagnostic measures of SCS and to investigate the availability of insülin hypoglycemia test (IHT) in the diagnosis of SCS. Twenty patients with adrenal incidentaloma CT characteristics highly suggestive of benign adrenal adenoma with no overt ...

ea0020p47 | Adrenal | ECE2009

Carotid intima media thickness is increased and associated with morning cortisol in subjects with non-functioning adrenal incidentaloma

Yener Serkan , Genc Sinan , Akinci Baris , Seci Mustafa , Demir Tevfik , Comlekci Abdurrahman , Ertilav Senem , Yesil Sena

Data regarding cardiovascular risk in subjects with non-functioning adrenal adenoma is limited. The aim of this study is to investigate carotid intima media thickness (IMT) as a robust indicator of atherosclerosis in subjects with AI.Of 49 subjects without findings of hypercortisolism or other adrenal gland disorders, 34 BMI-unmatched controls (C) and 18 BMI-matched controls (BC) were enrolled. Participants underwent hormonal evaluation including morning...

ea0020p48 | Adrenal | ECE2009

Cannabinoids and regulation of adipogenesis in differentiating 3t3-l1 preadipocytes

Isidori Andrea M , Lolli Francesca , Pierotti Silvia , Pozza Carlotta , Bonifacio Vincenzo , Gandini Loredana , Lenzi Andrea

Objective: Endocannabinoids (CBs) are novel lipid mediators that modulate appetitive behaviour and energy metabolism. The overactivation of the endocannabinoid system plays an important role in obesity. Endocannabinoids may regulate the lipid metabolism through their receptors (CB1 and CB2) in liver and adipose tissue. 11β-hydroxysteroid dehydrogenase (11β-HSD1) type 1 regulates the local availability of active glucocorticoid, potent inductors of adipogenic different...

ea0020p49 | Adrenal | ECE2009

Laparoscopic resection of a large adrenal oncocytoma

Michalopoulos Nikolaos , Kekis Panagiotis , Liparaki Maria , Evagelidakis Emmanuel , Natoudi Maria , Kleidi Eleftheria , Markogiannakis Haridimos , Manouras Andreas

Background: Oncocytomas are predominantly benign tumors that are well described in the kidney, thyroid and salivary glands. They have also been reported in more rare sites including the pituitary and parathyroid glands, respiratory tract and choroid plexus. The occurrence of these tumors in the adrenal gland, however, represents an extremely exceptional finding.Case presentation: We report the case of a 34 year-old male patient who presented with a right...

ea0020p50 | Adrenal | ECE2009

Effects of corticosterone intake as stress-alternative hormone on broiler chickens: performance and blood parameters

Vahdatpour Tohid

This study was conduced to determine effects of blood corticosterone (CS) increasing on some physiological parameters and performance of boiler chickens. To avoid treatment of birds with various forms of stress with administration of CS a model was developed to study of mimicked stress in chickens. Total 180 1-day old chicks of the cobb-500 strain from male sex were placed in 12 pens. CS at four levels (0, 10, 20, and 30 mgl/1) in drinking water was provided ad libitum ...

ea0020p51 | Adrenal | ECE2009

Evaluation of cardiovascular risk factors in patients with incidentally discovered adrenal adenoma during a follow-up longer than five years

Reimondo Giuseppe , Bovio Silvia , Pia Anna , Allasino Barbara , Ardito Arianna , Micossi Ilaria , Zaggia Barbara , Termine Angela , Angeli Alberto , Terzolo Massimo

The existing follow-up studies on patients with incidentally discovered adrenal adenoma (AA) focused almost exclusively on repeat imaging and endocrine work-up on a short period.Of consecutive 152 patients with AA referred to our center from 1989 to 2003, we have assessed the risk of developing metabolic disorders and vascular complications in the 74 patients who did not underwent surgery (51 women and 23 men, median age 57, range 25–74 years) durin...

ea0020p52 | Adrenal | ECE2009

Expression of mTOR pathway in human adrenocortical carcinomas and in vitro effects of mTOR inhibitors in human adrenocortical cell lines

De Martino Maria Cristina , van Koetsveld Peter , Sprij-Mooij Diana , Feelders Richard A , Lamberts Steven W J , de Herder Wouter W , Colao Annamaria , Pivonello Rosario , Hofland Leo J

Background: Adrenocortical carcinoma (ACC) is an uncommon malignancy with a still scantily understood pathogenesis and generally poor prognosis. Surgery, performed at early stages, offers the best chance for cure, but unfortunately, it is often noncurative. Medical treatment produced disappointing responses. mTOR inhibitors, such as sirolimus (S) and temsirolimus (T), are promising antineoplastic drugs in several types of carcinomas.Methods: To evaluate ...

ea0020p53 | Adrenal | ECE2009

Prospective evaluation of tumour size and hormone secretion in adrenal incidentalomas

Yener Serkan , Ertilav Senem , Secil Mustafa , Akinci Baris , Demir Tevfik , Comlekci Abdurrahman , Yesil Sena

Increased use and improved technology of imaging procedures have led to increased recognition of adrenal incidentalomas. The aim of this study is to evaluate the natural course of benign adrenal tumours in terms of tumour growth and hormone secretion.Subjects referred between 2001 and 2008 for the evaluation of adrenal tumours were included. Computed tomography (CT) was the initial radiological intervention. Initial hormonal evaluation included 1 mg or 2...

ea0020p54 | Adrenal | ECE2009

Rosiglitazone interferes with human adrenocortical carcinoma growth in a xenograft mouse model

Mangoni Monica , Gelmini Stefania , Nesi Gabriella , Poli Giada , Cantini Giulia , Lombardi Adriana , Orlando Claudio , Serio Mario , Mannelli Massimo , Luconi Michaela

Adrenocortical carcinoma (ACC) is a rare and aggressive tumour with a poor prognosis, characterized by radio/chemotherapy resistance. The lack of an effective medical treatment is due to the poor knowledge of the mechanisms underlying malignant tumour transformation and aggressiveness. In vitro studies on the ACC H295R cell model have demonstrated that RGZ, an antidiabetic drug belonging to the thiazolidinedione ligands of PPARgamma, blocks cell proliferation/migration ...