Searchable abstracts of presentations at key conferences in endocrinology

ea0051p041 | Pituitary and growth | BSPED2017

ACTH deficiency and potential for reversibility in children and young people (CYP) with craniopharyngioma

Pieri Kyriaki , Michaelidou Maria , Dastamani Antonia , Spoudeas Helen A.

Introduction: ACTH deficiency is life-threatening, but difficult to differentiate from ACTH suppression especially in children and young people (CYP) receiving perioperative corticosteroids for pituitary tumour surgery. In our experience, ACTH is the most, and GH the least robust anterior pituitary hormone, with LH/FSH and TSH intermediate in hierarchical loss.Aims: To assess potential misdiagnosis of ACTH suppression versus deficiency and time to adrena...

ea0039ep103 | Pituitary and growth | BSPED2015

Does better adherence to GH treatment using jet rather than needle delivery translate into improved growth outcomes?

Michaelidou Maria , Whitten Sue , Bajaj Priti , Spoudeas Helen

Introduction: We wanted to assess whether our report of better adherence to GH therapy using jet (ZomaJet) rather than needle delivery in a large nationwide cohort, translated into better growth outcomes.Aims and hypothesis: To retrospectively audit growth markers in our local split-site (GOSH/UCLH) cohort of children, starting GH using Zomajet between 01.01.2010 and 31.12.2012, for whom we had previous adherence (PDC) scores.Metho...

ea00100wf3.1 | Workshop F: Disorders of the parathyroid glands, calcium metabolism and bone | SFEEU2024

A case of hypocalcaemic hypoparathyroidism complicated by malabsorption, leading to refractory hypocalcaemia and repeated hospital admissions

Michaelidou Maria , Majeed Waseem , Brindle Rachel , Robinson Adam

Case Presentation: A 27-year-old female who recently moved to the UK, was referred to Endocrinology with suspected thyrotoxicosis. She was diagnosed with thyrotoxicosis 11 years prior, and was temporarily treated with a ‘block and replace’ regimen. She had history of traumatic brain injury with no long-term sequelae, and cholecystectomy leading to chronic diarrhoea. She reported swallowing difficulty and a choking sensation. Investigations identified hyperthyroidism ...

ea0094p35 | Bone and Calcium | SFEBES2023

Bones, physician’s moans, and causes unknown: a challenging case of multifactorial hypocalcaemia

Phillips Ben , Michaelidou Maria , Obeid Mariam , Dunstan Rosalyn , Laing Ian , Young Elaine , Howell Simon , Kaushal Kalpana

Sclerotic bone lesions are a rare cause of hypocalcaemia. Calcium and vitamin D malabsorption are recognised complications of gastric bypass surgery. We describe the case of a 45 year-old woman with severe persistent symptomatic hypocalcaemia secondary to metastatic breast cancer, complicated by a previous Roux-en-Y gastric bypass, and the development of hypoparathyroidism. Her corrected calcium levels fell repeatedly and precipitously despite treatment with up to 8g/day oral ...

ea0065p28 | Adrenal and Cardiovascular | SFEBES2019

Recalibration of thinking about adrenocortical function assessment: How the random cortisol relates to the short Synacthen test ‘Verdict’

Michaelidou Maria , Yadegarfar Ghasem , Robinson Adam , Naseem Asma , Khan Inamullah , Kochhar Rupinder , Scargill Jonathan , Trainer Peter , Heald Adrian

Background: The short synacthen test (SST) is the most commonly performed investigation to assess for suspected adrenocortical dysfunction. We investigated how random cortisol levels may relate to pass/fail on the STT.Methods: We analysed the relation between random cortisol measurements taken between 04.40 and 20.52 in the day and results of SST baseline and 30/60 min cortisol performed over a 12 month period (338 SSTs) at Salford Royal Hospital. Serum ...

ea0036oc4.9 | Oral Communications 4 | BSPED2014

Neurodevelopmental phenotypes in children with early and late presenting congenital hyperinsulinism

Mohamed Zainaba , Michaelidou Maria , Nicholson Jacqueline , Butler Thomas , Rigby Lindsey , Padidela Raja Narendra Rao , Cosgrove Karen E , Dunne Mark J , Clayton Peter , Banerjee Indraneel

Introduction: Adverse neurodevelopmental outcomes have been recognised in children with hypoglycaemia due to early and late presenting congenital hyperinsulinism (CHI). The Vineland Adaptive Behaviour Scales II (VABS-II) is a standardised measure used to assess parent reported adaptive behaviour. The test measures five domains; motor, communication, daily living skills (DLS), socialisation, and maladaptive behaviour. We have used VABS-II to identify specific neurodevelopmental...

ea0045p53 | Miscellaneous/other | BSPED2016

Vineland adaptive behaviour scales to identify neurodevelopmental problems in children with Congenital Hyperinsulinism (CHI)

Mohamed Zainaba , Banerjee Indraneel , Michaelidou Maria , Estabanez Maria , Dunne Mark J , Collins Hannah , Rigby Lindsey , Bowden Louise , Rust Stewart , Nicholson Jacqueline

Background: Congenital Hyperinsulinism (CHI) is a disease of severe hypoglycaemia due to insulin hypersecretion, that can be recognised either early or late in childhood. CHI is associated with adverse neurodevelopmental outcomes. The Vineland Adaptive Behaviour Scales Second Edition (VABS-II) is a parent-report measure of intellectual and developmental functioning, which could be used to screen children with CHI for impairments.Aims: To investigate reli...

ea0094cc5 | Section | SFEBES2023

A case of an ACTH-secreting phaeochromocytoma: Biochemical response to metyrapone suggests the presence of a glucocorticoid-driven positive feedback loop

Michaelidou Maria , Phillips Benjamin , Man Mung Sai , Al-Hayali Mohammed , Chen Lilian , Allcock Rebecca , Monaghan Phillip , Thirkettle Sally , Clarke Noel , Gulamhusein Aziz , Beards Sue , Hoong Ho Jan , Kaushal Kalpana , Howell Simon , Adam Safwaan

Phaeochromocytoma-driven Ectopic ACTH Syndrome (EAS) is rare. We report the case of a 31-year-old female, who presented with abdominal pain and vomiting. She had clinical features of severe Cushing’s syndrome (proximal myopathy, bruising, refractory hypertension and acute confusion). Admission investigations revealed hypokalaemia (2.1mmol/l [3.5-5.5mmol/l]) and a 4.5cm left adrenal lesion with a ’bulky’ right adrenal on CT abdomen. She was diagnosed with hyperte...

ea0039ep108 | Pituitary and growth | BSPED2015

Achieving a consensus on managing idiopathic thickening of the pituitary stalk through a national multidisciplinary forum, meeting virtually

Raman Nambisan Aparna Kesavath , Michaelidou Maria , Dimitrakopoulou Eftychia , Ederies Ash , Spoudeas Helen , Clayton Peter , Banerjee Indi , Visser Johannes , Blair Jo , Gevers Evelien , Dattani Mehul , Aquilina Kristian , Pettorini Benedetta , Albanese Assunta , Kamaly Ian , Korbonits Marta , Michalski Antony , Hargrave Darren , Pizer Barry , Chang Yen

Objectives: In 2010 we piloted a national multidisciplinary (MDT), meeting virtually to improve management of rare suprasellar (HPAT) tumours. In 2014 we reported centralised treatment decision-making in craniopharyngioma and now wished to examine whether centre based management of idiopathic thickening of the pituitary stalk (iTPS) differs and can be streamlined by wider debate. This might also inform current commissioned BSPED and CCLG guidance.Methods...