Searchable abstracts of presentations at key conferences in endocrinology

ea0035p99 | Bone and Osteoporosis | ECE2014

Effect of estroprogestagen treatment on bone mineral density and concentration of osteoprotegerin in girls with Turner syndrome

Sowinska-Przepiera Elzbieta , Andrysiak-Mamos Elzbieta , Walkowiak Aleksandra , Rudnicka Marta , Osowicz-Korolonek Lilianna , Syrenicz Anhelli

Background: Osteoprotegerin (OPG), a component of the RANKL/RANK/OPG pathway, can inhibit bone resorption by affecting osteoclastogenesis. Estrogens deficiency is associated with decreased expression of OPG and increased osteoclast activity, and thus can lead to disorders of bone remodeling.Objective: To analyze relationship between serum OPG and bone mineral density (BMD) in patients with Turner syndrome (TS) subjected to estroprogestagen (EP) treatment...

ea0056gp121 | Endocrine Case Reports | ECE2018

Coexistence of papillary thyroid cancer and malignancies of other organs in patients carrying CHEK2 gene mutations – case series.

Syrenicz Anhelli , Koziolek Monika , Sieradzka Anna , Rudnicka Marta , Kiedrowicz Bartek , Kazmierczyk-Puchalska Agnieszka

Introduction: CHEK2 mutations are associated with increased risk of having neoplasms of various organs, including thyroid, breast, colon, renal and ovarian cancers. Coexistence of thyroid and breast cancers was observed in female carriers of CHEK2 gene mutations. In polish population the most common mutations are those truncating CHEK2 protein (1100delC, IVS2+1G>A, del5395) and a missense I157T CHEK2 mutation. Carrying missense I157T mutation is connected with having twice...

ea0056gp238 | Thyroid Cancer - Translational | ECE2018

Carrying mutations truncating CHEK2 protein predisposes to thyroid neoplasms – preliminary report

Syrenicz Anhelli , Koziolek Monika , Rudnicka Marta , Sieradzka Anna , Cybulski Cezary , Kiedrowicz Bartek

Introduction: CHEK2 gene is one of the genes in the DNA repair complex. Dysfunction of genes in this complex leads to genomic instability and is regarded as a cause of tumorigenesis. CHEK2 mutations spectrum was assessed in many populations, including polish one. The most common are mutations truncating CHEK2 protein (1100delC, IVS2+1G>A, del5395) and a missense I157T CHEK2 mutation. Literature data indicate that mutations truncating CHEK2 protein lead to a five-fold incre...