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20th European Congress of Endocrinology

Barcelona, Spain
19 May 2018 - 22 May 2018

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ECE 2018, 19 - 22 May 2018; Barcelona, Spain

Guided Posters

Thyroid Cancer - Translational

ea0056gp236 | Thyroid Cancer - Translational | ECE2018

Neural stem cells expressing cytosine deaminase and interferon-β suppressed the growth and metastasis of anaplastic thyroid cancer cells

Shin Hye-Ji , Choi Kyung-Chul

In this study, human neural stem cells (hNSCs) were used to cancer treatment strategy for anaplastic thyroid cancer (ATC) owing to their tumor tropic properties. Cytosine deaminase (CD) can convert a prodrug, 5-fluorocytosine (5-FC), to drug, 5-fluorouracil (5-FU), which inhibits tumor growth through DNA synthesis inhibition. Also, IFN-β expression suppresses tumor growth by apoptotic process. Then, we investigated tumor inhibition effect of hNSCs in vitro and <e...

ea0056gp237 | Thyroid Cancer - Translational | ECE2018

Comparison in survival of the seventh and eighth editions of the American Joint Commision on Cancer in a Spanish cohort of differentiated thyroid carcinoma: Cadit-CAM Study

Sastre Julia , Torres Belvis , Aznar Silvia , Alvarez Visitacion , Delgado Manuel , Gonzalez Javier , Quiroga Ivan , Herranz Sandra , Alfaro Jose Joaquin , Aguirre Miguel

Background and objective: The AJCC-TNM system is optimized to predict survival in patients with cancer. Since January 2018, the new eighth edition of this staging system will be used to classify patients diagnosed of differentiated thyroid carcinoma (DTC). This study aims to compare the seventh and eighth editions of the AJCC-TNM system in a Spanish Cohort of DTC.Patients and Methods: The Cadit-CAM study was designed to evaluate characteristics of patien...

ea0056gp238 | Thyroid Cancer - Translational | ECE2018

Carrying mutations truncating CHEK2 protein predisposes to thyroid neoplasms – preliminary report

Syrenicz Anhelli , Koziolek Monika , Rudnicka Marta , Sieradzka Anna , Cybulski Cezary , Kiedrowicz Bartek

Introduction: CHEK2 gene is one of the genes in the DNA repair complex. Dysfunction of genes in this complex leads to genomic instability and is regarded as a cause of tumorigenesis. CHEK2 mutations spectrum was assessed in many populations, including polish one. The most common are mutations truncating CHEK2 protein (1100delC, IVS2+1G>A, del5395) and a missense I157T CHEK2 mutation. Literature data indicate that mutations truncating CHEK2 protein lead to a five-fold incre...

ea0056gp239 | Thyroid Cancer - Translational | ECE2018

The capability of the Bethesda System Reporting for Thyroid Cytopathology (TBSRTC) in identifying of thyroid carcinoma

Nechaeva Olga , Bavykina Larisa , Kazaryan Armine , Britvin Timur , Dreval Alexander

Aim: To assess the accuracy of the TBSRTC in verification of thyroid carcinoma in the region of Moscow county.Material and methods: A retrospective study of data from electronic medical notes of 1,675 patients who underwent fine needle aspiration biopsy of nodular thyroid glands in 2016. The cytological conclusion was evaluated in accordance with the TBSRTC. In cases of surgical treatment (thyroidectomy or hemithyroidectomy) the cytological diagnosis was...

ea0056gp240 | Thyroid Cancer - Translational | ECE2018

Orthotopic PDX Mouse Model of humanprimary Undifferentiated/Anaplastic thyroid carcinoma

Chenlo Miguel , Rodrigues Joana , Freire Manuel Narciso Blanco , del Carmen Suarez Farina Maria , Piso-Neira Magali , Cameselle-Teijeiro Jose M , Alvarez Clara V

Undifferentiated/Anaplastic thyroid carcinoma (ATC) is one of the most aggressive and deadly cancers. It is characterized by loss of thyroid expression markers and no response to conventional treatments. ATC incidence is low representing <2% of all thyroid carcinomas. This, together with its high mortality, makes difficult the development of clinical trials. In our previous works, we have developed a system to culture patient-derived thyroid cancer cells (h7H) that is a go...

ea0056gp241 | Thyroid Cancer - Translational | ECE2018

Detection of lncRNAs in thyroid nodule as new tool for tumor diagnosis: analysis by Droplet Digital PCR in Fine Needle Aspiration biopsy

Nanni Simona , Locantore Pietro , Bacci Lorenza , Aurora Aiello , Fadda Guido , Traini Emanuela , Bellantone Rocco , Grassi Claudio , Farsetti Antonella , Pontecorvi Alfredo

Background: Differentiated Thyroid Carcinomas (DTC) represent more than 90% of thyroid tumors with good prognosis and long survival. Currently, patients with intermediate/high risk nodule as assessed by cytological staging may undergo surgery. According to ATA 2017 guidelines, all patients presenting thyroid nodules with suspicious ultrasound features (hypoechoic pattern, irregular margins, microcalcifications, etc.) and cytopathology TIR3B, TIR4 or TIR5 according to 2014-SIAP...

ea0056gp242 | Thyroid Cancer - Translational | ECE2018

New markers of follicular thyroid cancer found with wide-panel next-generation sequencing

Borowczyk Martyna , Szczepanek-Parulska Ewelina , Debicki Szymon , Budny Bartlomiej , Janicka-Jedynska Malgorzata , Wrotkowska Elzbieta , Majchrzycka Blanka , Ziemnicka Katarzyna , Ruchala Marek

Introduction: Thyroid nodules may be detected in up to 67% of the adult population and constitute big diagnostic challenge. Presurgical differentiation of follicular lesions between follicular adenoma (FA) and follicular thyroid carcinoma (FTC) is particularly difficult. Commercially available gene panels cover only a few, selected mutations to help in discrimination between FA and FTC. The aim of this study was to comprehensively assess the genetic background of thyroid folli...

ea0056gp243 | Thyroid Cancer - Translational | ECE2018

Prognostic value of N0 classification in differentiated thyroid cancer

Marques Bernardo , Martins Raquel , Couto Joana , Santos Jacinta , Martins Teresa , Rodrigues Fernando

Introduction: The TNM classification of the American Joint Committee on Cancer (AJCC) and the Union for International Cancer Control (UICC) is the most widely used thyroid cancer staging system. The 8th edition was published in 2016 and introduced modifications to the N0 classification. Histological analysis is no longer necessary for patients to be classified as N0, as long as there is no evidence of lymph node (LN) metastasis in the preoperative imaging tests or clinical eva...

ea0056gp244 | Thyroid Cancer - Translational | ECE2018

Implementation of the British Thyroid Association thyroid nodule classification: a general UK hospital perspective

Dede Anastasia , Mavroeidi Niki , Mazzoni Daniel , Smellie James , Mitra Indu , Morganstein Daniel

Introduction: In 2014, the British Thyroid Association (BTA) issued guidance on thyroid cancer and introduced a new scoring system for thyroid nodules based on their sonographic appearances (U1-U5). The guidelines specified that nodules with indeterminate or suspicious appearances (U3-U5) should undergo fine needle aspiration (FNA) assessment. This study audits the implementation of the guidelines in our hospital and evaluates any changes in the management of thyroid nodules.<...

ea0056gp245 | Thyroid Cancer - Translational | ECE2018

Dynamic risk stratification in the follow-up of children and adolescents with differentiated thyroid cancer

Scheffel Rafael Selbach , Zanella Andre Borsatto , Nava Carla Fernanda , Golbert Lenara , de Souza Meyer Erika Laurini , Punales Marcia , Goncalves Iracema , Dora Jose Miguel , Maia Ana Luiza

Context: Risk stratification for persistent disease is an important step in pediatric differentiated thyroid cancer (DTC) management. The dynamic risk stratification (DRS) is a well validated system for adults, but not yet for children and adolescents.Objective: To evaluate DRS performance and other prognostic factors in pediatric DTC.Design: Cohort study.Setting: Four DTC referral centers at tertiary teachin...