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20th European Congress of Endocrinology

Barcelona, Spain
19 May 2018 - 22 May 2018

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ECE 2018, 19 - 22 May 2018; Barcelona, Spain

Guided Posters

Thyroid Cancer - Diagnostics & Treatments

ea0056gp224 | Thyroid Cancer - Diagnostics & Treatments | ECE2018

Association between preoperative thyrotrophin and clinicopathological and aggressive features of papillary thyroid cancer

Ali Tam Abbas , Ozdemir Didem , Aydin Cevdet , Bestepe Nagihan , Ulusoy Serap , Sungu Nuran , Ersoy Reyhan , Cakir Bekir

Aim: We aimed to investigate the relation between preoperative serum thyrotrophin (TSH) and clinicopathological features in patients with papillary thyroid carcinoma (PTC) and microcarcinoma (PTMC).Methods: Patients who underwent thyroidectomy and diagnosed to have benign nodular disease or PTC/PTMC in our clinic were evaluated retrospectively. Patients with a previous history of thyroid surgery, patients using antithyroid medications or thyroid hormone ...

ea0056gp225 | Thyroid Cancer - Diagnostics & Treatments | ECE2018

Germline mutations in KIF1B gene in two families with familial non-medullary thyroid cancer (FNMTC)

Anon Aida Orois , Porta Mireia Mora , Rabinovich Irene Halperin , Gara Sudheer Kumar , Kebebew Electron , Ambros Josep Oriola

Introduction: Familial non-medullary thyroid cancer(FNMTC) represents 3–9% of thyroid cancer cases. Although the susceptibility genes for syndromic FNMTC are known, most cases of FNMTC are nonsyndromic and the genetic causes are unknown.Patients and methods: We conducted a multicenter study to identify a candidate susceptibility gene for nonsyndromic FNTMC. We collected blood specimens, clinical and pathological data from 38 kindreds with FNMTC (32 ...

ea0056gp226 | Thyroid Cancer - Diagnostics & Treatments | ECE2018

Significant acceleration in dynamics of medullary thyroid cancer markers concentration – report of 26 cases

Gawlik Tomasz , Krajewska Jolanta , Kukulska Aleksandra , Wygoda Zbigniew , Szpak-Ulczok Sylwia , Krol Aleksandra , Puch Zbigniew , Jarzab Barbara

Calcitonin and carcinoembryonal antigen are biochemical markers of medullary thyroid carcinoma (MTC). Assessment of the dynamics of their serum concentration allow for calculation of their doubling times that are independent risk factors for overall survival and progression-free survival in MTC. It is generally accepted that the dynamics and the doubling times remain stable during follow-up.Aim: The aim of the study was to retrospectively verify the stab...

ea0056gp227 | Thyroid Cancer - Diagnostics & Treatments | ECE2018

The adverse effect of radioactive iodine therapy on bone marrow for differentiated thyroid cancer patients

Kuo Sheng-Fong , Huang Bie-Yui , Lin Jen-Der

Aims: Side effects of large dose of radioactive iodine (RAI) therapy for well-differentiated thyroid carcinoma are noted.There were insufficient data regarding bone marrow suppression and inflammatory response in patients with thyroid cancer who received RAI therapy in Asia;Patients and methods: We performed the study at the Chang Gung Memorial Hospital in Keelung, Taiwan. Patients with papillary or follicular thyroid cancer who received more than 2.6 GB...

ea0056gp228 | Thyroid Cancer - Diagnostics & Treatments | ECE2018

Familial non-medullary thyroid carcinoma. Are we facing a different entity?

Remon-Ruiz Pablo , Romero-Lluch Ana , Duenas-Disotuar Suset , Cuenca Ignacio , Martos-Martinez Juan , Navarro Elena

Background: Familial non medullary thyroid carcinoma (FNMTC) is a not very well known histopatologic entity. Nowadays there are controversial publications about his aggresiveness and prognosisObjective: To know the clinical outcomes and histopathological characteristics of our patients with FNMTC and to compare them with a cohort of patients with sporadic non medullary thyroid carcinoma (CDT).Methods: We conducted a retrospective d...

ea0056gp229 | Thyroid Cancer - Diagnostics & Treatments | ECE2018

Is thyroid nodule size a factor to consider when deciding for fine-needle aspiration procedure?

Kuprionis Gintaras , Staras Zygimantas , Marcinkute Ugne , Makstiene Jurgita , Sarauskas Valdas , Barsiene Lina

Introduction: Fine-needle aspiration (FNA) is the most accurate diagnostic approach for determining thyroid nodule malignancy. Most nodules are benign, therefore, only suspicious ones require FNA. In 2017 American College of Radiology proposed a scoring system – Thyroid Imaging, Reporting and Data System (TI-RADS) for identifying clinically significant malignancies. Whether a nodule requires FNA depends on various criteria, one of which is the size. The aim of this study ...

ea0056gp230 | Thyroid Cancer - Diagnostics & Treatments | ECE2018

Peptide receptor radionuclide therapy in patients with medullary thyroid carcinoma: predictors and pitfalls

Beukhof Carolien , Brabander Tessa , van Nederveen Francien , van Velthuysen Loes , van Kemenade Folkert , de Rijke Yolanda , Froberg Lideke , Kam Boen , de Herder Wouter , Peeters Robin

Aim: To evaluate the effectiveness of Peptide Receptor Radionuclide Therapy with 177Lu-octreotate (PRRT) for medullary thyroid carcinoma (MTC).Background: There are few therapeutic options for progressive metastatic MTC. The Erasmus MC Center for Neuroendocrine Tumors has been at the forefront of developing PRRT for neuroendocrine tumors. PRRT has also been suggested to be a useful treatment for MTC, but evidence is very limited.<p class="...

ea0056gp231 | Thyroid Cancer - Diagnostics &amp; Treatments | ECE2018

Related recurrence factors in a Spanish cohort of differentiated thyroid carcinoma. Cadit-CAM Study

Quiroga Ivan , Sastre Julia , Delgado Manuel , Aznar Silvia , Alvarez Visitacion , Torres Belvis , Gonzalez Javier , Lamas Cristina , Llaro Mary Gaby , del Val Florentino , Calderon Dulce , Lop Jose

Background and objective: Incidence of differentiated thyroid cancer (DTC) is increasing but not its mortality. Knowing recurrence factors is essential to plan its treatment. Recurrence related factors in our area were reviewed and compared with ATA risk stratification system.Patients and Methods: The Cadit-CAM study was designed to evaluate characteristics of patients diagnosed of DTC in Castilla La Mancha, a region in the central part of Spain, during ...

ea0056gp232 | Thyroid Cancer - Diagnostics &amp; Treatments | ECE2018

Imaging in clinical research devoted to medullary thyroid carcinoma: a systematic meta-analysis

Kushchayev Sergiy , Teytelboym Oleg

Background: We analyzed the role of imaging in the identification of medullary thyroid carcinoma (MTC) metastases and in the assessment of treatment response of the patients in clinical trials and research studies devoted to MTC.Materials and methods: A search for published studies devoted to MTC from January 2010 to August 2017 was performed.Results: Fifteen studies published in peer review journals that evaluated the effects of s...

ea0056gp233 | Thyroid Cancer - Diagnostics &amp; Treatments | ECE2018

Molecular profiling of a large papillary thyroid cancer series followed at a single center: data on mutation density, heterogeneity and phenotype-genotype correlations

Colombo Carla , Muzza Marina , Proverbio Maria Carla , Tosi Delfina , Pesenti Chiara , Rossi Stefania , Cirello Valentina , De Leo Simone , Bulfamante Gaetano , Ferrero Stefano , Tabano Silvia , Fugazzola Laura

Recent advances in the molecular classification of papillary thyroid cancer (PTC) have improved the diagnostic work-up and the care of patients with thyroid nodules and cancer, highlighting the need to routinely add information on the genetic pattern to the classification of cancer. The genomic background of a large series of 208 PTCs followed at a single Center was analysed by a custom MA genotyping platform (PTC-MA), which allows the simultaneous detection of 19 genetic alte...

ea0056gp234 | Thyroid Cancer - Diagnostics &amp; Treatments | ECE2018

Title Evaluation of the CCK-2-receptor agonist 177Lu-PP-F11N for peptide receptor radionuclide therapy (PRRT) of medullary thyroid carcinoma - First results of a phase 0 ‘Lumed’ Study

Rottenburger Christof , Nicolas Guillaume , McDougall Lisa , Kaul Felix , Cachovan Michael , Schibli Roger , Geistlich Susanne , Behe Martin , Wild Damian , Christ Emanuel

Objectives: There is still an unmet need for an effective systemic therapy for advanced medullary thyroid carcinoma (MTC). Targeting the cholecystokinine-2 (CCK-2) receptor with radiolabelled gastrin analogues is a potential approach for radionuclide therapy, as MTC expresses CCK-2 receptors at a high incidence and density. Unfortunately, kidney and bone marrow toxicity precluded therapeutic applications of CCK-2 receptor specific compounds until now. The aim of this prospecti...

ea0056gp235 | Thyroid Cancer - Diagnostics &amp; Treatments | ECE2018

Does body mass index influence the clinical stage, treatment response and course of the disease in patients with differentiated thyroid cancer?

Gesior-Perczak Danuta , Palyga Iwona , Szymonek Monika , Kowalik Artur , Walczyk Agnieszka , Kopczynski Janusz , Lizis-Kolus Katarzyna , Trybek1 Tomasz , Mikina Estera , Szyska-Skrobot Dorota , Gadawska-Juszczyk Klaudia , Hurej Stefan , Szczodry Artur , Sluszniak Janusz , Mezyk Ryszard , Gozdz Stanislaw , Kowalska Aldona

Introduction: Obesity is a serious health problem worldwide, especially in well developed countries. It is a cause of various diseases, including thyroid cancer. The relationship between obesity and prognostic factors of thyroid cancer is uncertain.Aim of the study: Evaluation of relationship between the body mass index (BMI) and clinicopathological features increasing the risk of poor clinical course, treatment response and clinical outcome in patients ...