Searchable abstracts of presentations at key conferences in endocrinology
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20th European Congress of Endocrinology

Barcelona, Spain
19 May 2018 - 22 May 2018

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ECE 2018, 19 - 22 May 2018; Barcelona, Spain

Guided Posters

Reproduction

ea0056gp214 | Reproduction | ECE2018

Sperm DNA fragmentation index as a promising predictive tool for male infertility diagnosis and treatment management

Santi Daniele , Spaggiari Giorgia , Simoni Manuela

Background: Conventional parameters evaluated in semen analysis show several limits in the diagnostic setting of male infertility and do not provide any useful prognostic tool for assisted reproductive technique (ART). On the contrary, the assessment of sperm DNA fragmentation (sDF) was proposed to discriminate fertile from infertile men and to predict the follicle stimulating hormone (FSH) treatment response in infertile men. However, a comprehensive evaluation thereof is not...

ea0056gp215 | Reproduction | ECE2018

Alleviation of perfluorooctanesulfonate (PFOS)-induced disruption of blood-testis barrier by altering cell signaling molecule expression in human sertoli cells.

Chen H , Cheng CY , Lee WM

Perfluorooctanesulfonate (PFOS) and its related product perfluorooctanic acid (PFOA) are anthropogenic fluorosurfactants widely used in consumer products. In general, studies in rodents have supported the conception that PFOS perturbs testis function, such as by inducing Sertoli cell injury. It remains to be demonstrated if similar effects could be reproduced in humans. We sought to examine its effects on human spermatogenesis by using a human Sertoli cell primary culture syst...

ea0056gp216 | Reproduction | ECE2018

Sertoli cell-specific knockout of coxsackie and adenovirus receptor (Cxadr) disrupts the blood-testis barrier and causes impaired fertility

Huang Kun , Lui Wing-Yee

Coxsackievirus and adenovirus receptor (CXADR) is localized at the blood-testis barrier (BTB) and at the interface between Sertoli cells (SC) and germ cells (GC). Earlier studies indicated that CXADR plays role in BTB function and germ cell migration. However, conventional knockout of CXADR leads to embryonic lethality, making the study of CXADR in the testis impossible. We aim to generate SC-specific CXADR knockout (KO) mice to evaluate the SC-specific function of CXADR on sp...

ea0056gp217 | Reproduction | ECE2018

The first Belgian series of 56 patients with congenital hypogonadotropic hypogonadism (CHH): genetic and brain abnormalities

Valdes-Socin Hernan , Libioulle Cecile , Harvengt Julie , Pintiaux Axelle , Jonas Christelle , Parent Anne Simone , Geenen Vincent , Corman Vincianne , Debray Francois Guillaume , Dideberg Vincianne , T'Sjoen Guy , De Leerner Anne , Beckers Dominique , Destree Anne , Roland Dominique , Lederer Damien , Boscolo Marina , Bours Vincent , Maiter Dominique , Beckers Albert

Introduction: CHH is a genetic syndrome that combines reproductive and brain abnormalities. The brain phenotype has been incompletely characterized. We aimed to study neuroradiological and genetic features in this first Belgian series of patients with CHH.Methods: A series of 56 adult patients (48 males, 8 females) presenting with CHH was investigated for a panel of 16 genes related to hypogonadotropic hypogonadism by next generation sequencing on a MiSe...

ea0056gp218 | Reproduction | ECE2018

Bioassay-based characterization of novel androgens

Heather Alison , Cooper Elliot , Cawley Adam

Chemical-analytical methods are currently in use as the gold standard approach for the detection of androgens, designer androgens and selective androgen receptor modulators (SARMs) in serum and urine samples from athletes as well as in sports supplements. These methods are exquisitely sensitive and selective. However, they have the disadvantage in that the androgens that being surveyed for must have delineated structures. Designer androgens or SARMs that have divergent structu...

ea0056gp219 | Reproduction | ECE2018

Mitochondrial phenotype of FOXL2 variants associated with Blepharophimosis, Ptosis and Epicantus Inversus Syndrome (BPES)

Ferrari Ilaria , Rossetti Raffaella , Bigoni Stefania , Petrone Lisa , Persani Luca

Primary ovarian insufficiency (POI) is a highly heterogeneous condition defined by the occurrence of amenorrhoea, hypoestrogenism and hypergonadotropinism in women under 40. POI onset can be triggered by multiple factors, such as iatrogenic events, environmental conditions, autoimmunity or genetic alterations. When the ovarian insufficiency occurs as a consequence of either chromosomal or genetic alterations, it can be associated with other congenital abnormalities and classif...

ea0056gp220 | Reproduction | ECE2018

Depletion of the primate-specific luteinizing-hormone receptor splice variant ‘exon-6A’ impairs LH-, but not hCG-mediated signaling in human primary granulosa cells

Casarini Livio , Riccetti Laura , Sperduti Samantha , Lazzaretti Clara , Masini Alessia , Simoni Manuela

Introduction: A primate-specific luteinizing hormone (LH) receptor (LHCGR)-variant was suspected to discriminate between maternal choriogonadotropin (hCG)- and fetal LH-functioning. It is the so-called “LHCGRex6A”, truncated, intracellular receptor isoform produced by alternative cryptic exon stop-codons located between the 6th-7th out of 11 exons. Its function is unknown, although pseudohermaphroditism and 46-XY female-like phenotype were associated with LHCGRex...

ea0056gp221 | Reproduction | ECE2018

The value of androstenedione and DHEA-S levels in diagnosis of polycystic ovary syndrome in young women

Kruszynska Aleksandra , Tuszynska Agata , Slowinska-Srzednicka Jadwiga

Context: Polycystic ovary syndrome (PCOS) is a very common endocrinopathy affecting approximately 6–18% of women of reproductive age. It is also the most common cause of infertility due to anovulation. PCOS is characterized by menstrual disorders, polycystic or enlarged ovaries on ultrasound, but hyperandrogenism is the central feature of PCOS. Assessing of serum testosterone level (T) or free T is recommended by the guidelines in the diagnosis of PCOS. Diagnostic value o...

ea0056gp222 | Reproduction | ECE2018

Change in visceral fat and its relation with change in lipids in trans persons during hormonal therapy: results from a multicenter prospective study

Klaver Maartje , Wiepjes Chantal , de Blok Christel , Nota Nienke , Defreyne Justine , Schneider Thomas , Fisher Alessandra , T'Sjoen Guy , den Heijer Martin , de Mutsert Renee

Introduction: Excess visceral adipose tissue (VAT) is strongly related to multiple cardiovascular risk factors such as dyslipidemia. Hormonal therapy (HT) in trans persons affects total body fat and body fat distribution, but the effect on VAT and its relation to changes in lipids is unknown. The aim of our study was to investigate the effect of one year HT on changes in VAT and its relation with changes in total cholesterol, HDL, LDL, and triglycerides after one year of HT.</...

ea0056gp223 | Reproduction | ECE2018

GHR ablation in the brain or in leptin receptor expressing cells causes metabolic effects during pregnancy

Teixeira Pryscila DS , Furigo Isadora C , Donato Jose

Introduction: Pregnancy leads to extensive adaptations in the female’s body, by changing the secretion and responses to several hormones. GH is required for fetal nutrition, growth during pregnancy and for mammary development and lactation, although its central effects are not completely clarified.Aim: The aim of this study was to investigate whether central GH signaling regulates physiological and metabolic adaptations during pregnancy.<p class...