Endocrine Abstracts

Primary aldosteronism has been recognized as a common cause of secondary hypertension, accounting for approximately 10% of patients in hypertension clinics and 5% in primary care. Long-standing aldosteronism is associated with refractory hypertension, severe hypokalemia, and consecutive cardiovascular consequences: atrial fibrillation, myocardial infarction, heart failure, stroke, and renal failure. Less well-recognized features of primary aldosteronism is impaired quality of ...

Objective: Isolated ACTH-deficiency (IAD) is considered a rare autoimmune endocrinopathy most frequently associated with autoimmune thyroid diseases (ATD). We have previously diagnosed IAD in four patients with primary hypothyroidism and negative TPO antibodies. The aim of this study was to determine the prevalence of undiagnosed IAD in patients with ATD.Methods: We studied 45 patients with ATD on stable L-thyroxine replacement (dose range...

Background: Current guidelines recommend adrenal vein sampling (AVS) for the identification of surgically treatable unilateral disease among patients with primary aldosteronism (PA). The cortisol-derived selectivity index (SI) is currently used to assess the success (or selectivity) of adrenal vein catheterization during AVS. However, AVS studies can be non-selective in many cases.Aim: To examine whether the use of SI derived either from 11-deoxycortisol...