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ea0025oc4.7 | Bone and diabetes | SFEBES2011

Co-administration of the gut hormones PYY and GLP-1 to human volunteers reduces food intake and brain activation in appetite centres

De Silva Akila , Salem Victoria , Long Christopher J , Makwana Aidan , Newbould Rexford D , Rabiner Eugenii A , Tavare Aniket N , Ghatei Mohammed A , Bloom Stephen R , Matthews Paul M , Beaver John D , Dhillo Waljit S

The physiological post-prandial release of the gut hormones PYY and GLP-1 is implicated in triggering CNS mechanisms underlying satiety. However, the combined effects of PYY and GLP-1 on brain circuits underlying satiety in humans remain unknown.Objective: To determine changes in CNS neuronal activity following single and combined infusions of PYY and GLP-1, using blood oxygen level dependent functional magnetic resonance imaging (BOLD fMRI) in human vol...

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Co-administration of the gut hormones PYY and GLP-1 to human volunteers reduces food intake and brain activation in appetite centres

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