Searchable abstracts of presentations at key conferences in endocrinology
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Society for Endocrinology BES 2011

Oral Communications

Bone and diabetes

ea0025oc4.1 | Bone and diabetes | SFEBES2011

A mouse with an ENU-induced mutation (Tyr209Asn) in the natriuretic peptide receptor 3 (Npr3) develops autosomal recessive kyphosis

Esapa Christopher , Head Rosie , Thomas Gethin , Brown Matthew , Croucher Peter , Cox Roger , Brown Steve , Thakker Rajesh

Kyphosis is a common spinal disorder affecting up to 8.3% of the population, and associated with significant morbidity. Familial and twin studies have implicated a genetic involvement. However, the causative genes have not been identified. Studies investigating the underlying molecular mechanisms are hampered by genetic heterogeneity, small families and variable modes of inheritance displayed by different kindreds. To overcome these limitations, we investigated 12 week old pro...

ea0025oc4.2 | Bone and diabetes | SFEBES2011

Is Mepe a novel regulator of growth plate mineralisation?

Staines Katherine , MacRae Vicky , Farquharson Colin

Advances in the understanding of hypophosphatemic disorders have identified a novel group of molecules (FGF23, PHEX, MEPE, DMP1) that have been implicated in osteoblast mineralisation directly.The specific binding of PHEX to MEPE regulates the release of ASARM peptides which have an inhibitory role. Current concepts are speculative and the functional role of MEPE in chondrocyte mineralisation remains largely undefined.Proximal tibiae from 3-week old wild...

ea0025oc4.3 | Bone and diabetes | SFEBES2011

Rapid bone turnover responses to increased hypothalamic–pituitary–thyroid-axis activity are mediated by thyroid hormones

Gogakos Apostolos , Murphy Elaine , Bassett Duncan , Williams Graham

Increased hypothalamic–pituitary–thyroid (HPT) axis activity results in high bone turnover. T3 stimulates osteoblast and osteoclast activities, whereas TSH is proposed to inhibit bone turnover directly. Resolving the relative importance of T3 and TSH is complicated by their physiological inverse relationship. We studied 10 controls and 4 patients with resistance to thyroid hormone (RTH), in which mutation of thyroid hormone receptor beta (THR...

ea0025oc4.4 | Bone and diabetes | SFEBES2011

CB1 receptor mediates the effects of glucocorticoids on AMPK activity in the hypothalamus but not in adipose tissues

Scerif Miski , Kola Blerina , Fekete Csaba , Grossman Ashley B , Korbonits Marta

Introduction: Adenosine monophosphate-activated protein kinase (AMPK) is a regulator of cellular and systemic energy homeostasis. Many of the changes seen in glucocorticoid excess correspond to the metabolic steps regulated by AMPK. In the hypothalamus and adipose tissues, glucocorticoids and cannabiniods share the same tissue specific effects on AMPK activity. Cannabinoids have central orexigenic and peripheral metabolic effects via the cannabinoid receptor type 1 (CB1). The ...

ea0025oc4.5 | Bone and diabetes | SFEBES2011

Alterations to hypothalamic 5-HT and DA turnover in offspring induced by maternal exposure to a high caloric diet throughout lactation

Wright Thomas , Voigt Peter , Langley-Evans Simon

Exposure to maternal obesity or overfeeding during early development has lasting effects upon the young adult rat. Maternal cafeteria (CD) feeding during lactation programmes behaviour in the adult offspring, reducing anxiety in males and altering the behavioural satiety sequence in females. The aim of the present study was to examine the impact of early exposure to maternal over-nutrition upon bioactive amines in the brain. Lactating Wistar rats were fed either a control chow...

ea0025oc4.6 | Bone and diabetes | SFEBES2011

Dual effect of arachidonic acid on peroxisome proliferator-activated receptor γ (PPARγ)-dependent action in 3T3-L1 adipocytes

Nikolopoulou Evanthia , Parker Malcolm , Christian Mark

Dietary fat has been correlated with obesity since it induces the proliferation and differentiation of pre-adipocytes. Now it has become clear that the effect of fat on human health depends on the composition and the nature of fatty acids. Arachidonic acid (AA) is a major omega-6 polyunsaturated fatty acid (PUFA) with a controversial role in adipocyte differentiation. We investigated the effect on pre-adipocyte differentiation after a brief exposure to AA.<p class="abstext...

ea0025oc4.7 | Bone and diabetes | SFEBES2011

Co-administration of the gut hormones PYY and GLP-1 to human volunteers reduces food intake and brain activation in appetite centres

De Silva Akila , Salem Victoria , Long Christopher J , Makwana Aidan , Newbould Rexford D , Rabiner Eugenii A , Tavare Aniket N , Ghatei Mohammed A , Bloom Stephen R , Matthews Paul M , Beaver John D , Dhillo Waljit S

The physiological post-prandial release of the gut hormones PYY and GLP-1 is implicated in triggering CNS mechanisms underlying satiety. However, the combined effects of PYY and GLP-1 on brain circuits underlying satiety in humans remain unknown.Objective: To determine changes in CNS neuronal activity following single and combined infusions of PYY and GLP-1, using blood oxygen level dependent functional magnetic resonance imaging (BOLD fMRI) in human vol...

ea0025oc4.8 | Bone and diabetes | SFEBES2011

Hyperghrelinaemia, hyperphagia, food hoarding and reduced adiposity in an imprinting centre deletion mouse model of Prader–Willi syndrome

Wells Timothy , Relkovic Dinko , Furby Hannah , Guschina Irina , Nishimura Sachiko , Resnick James , Isles Anthony

Prader–Willi syndrome (PWS) is a neurodevelopmental disorder caused by a lack of paternal gene expression from 15q11–q13 and is characterised by failure to thrive in infancy, followed by hyperphagia due to abnormal satiety responses and increased motivation by food. We investigated growth and metabolism a mouse model in which the imprinting centre (IC) of the homologous PWS interval has been deleted (PWS-IC mice). Growth retardation only emerged post-natally, with ad...