ea0025oc4.2 | Bone and diabetes | SFEBES2011
, MacRae Vicky
, Farquharson Colin
Advances in the understanding of hypophosphatemic disorders have identified a novel group of molecules (FGF23, PHEX, MEPE, DMP1) that have been implicated in osteoblast mineralisation directly.The specific binding of PHEX to MEPE regulates the release of ASARM peptides which have an inhibitory role. Current concepts are speculative and the functional role of MEPE in chondrocyte mineralisation remains largely undefined.Proximal tibiae from 3-week old wild...