Searchable abstracts of presentations at key conferences in endocrinology
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Society for Endocrinology BES 2011

Oral Communications

Pituitary and thyroid

ea0025oc3.1 | Pituitary and thyroid | SFEBES2011

Development of a novel mass spectroscopy-based method for determining serum IGF1: assessment in a cohort of newly diagnosed subjects with acromegaly

Halsall David , Kay Richard , Taylor Kevin , Annamalai Anand , Kandasamy Narayanan , Wark Gwen , Pleasance Steve , Gurnell Mark

Background: The recently published ‘Consensus on Criteria for Cure of Acromegaly’ (Giustina et al. JCEM, 2010) highlighted concerns regarding the quality of currently available insulin-like growth factor 1 (IGF1) immunoassays which may contribute, at least in part, to the discordance between GH and IGF1 that is observed in up to 30% of patients with acromegaly after treatment. The development of mass spectroscopy (MS)-based technology has been proposed ...

ea0025oc3.2 | Pituitary and thyroid | SFEBES2011

Determination of method-specific normal cortisol responses to the short Synacthen test

El-Farhan Nadia , Pickett Alan , Ducroq David , Bailey Catherine , Parham Kelly , Morgan Nicola , Armston Anne , Evans Carol , Rees Dafydd Aled

Introduction and aims: The short Synacthen test (SST) is used to diagnose underactivity of the HPA axis, with a cortisol response <550 nmol/l at 30 min widely accepted as diagnostic of adrenal insufficiency. Earlier studies of the SST have shown variation in cortisol concentrations measured by different immunoassays, suggesting the need for method-specific cut-offs. We sought to define the cortisol response to Synacthen in healthy volunteers (HV) and establish method-speci...

ea0025oc3.3 | Pituitary and thyroid | SFEBES2011

miR-107 inhibits the expression of aryl hydrocarbon receptor interacting protein (AIP) and is potentially involved in pituitary tumorigenesis

Trivellin Giampaolo , Igreja Susana , Garcia Edwin , Chahal Harvinder , Butz Henriett , Patocs Attila , Grossman Ashley , Korbonits Marta

Background: Abnormal microRNAs (miRNAs) expression profiles have been recently associated with sporadic pituitary adenomas, suggesting that miRNAs can contribute to tumor formation. miRNAs are small noncoding RNAs which inhibit post-transcriptional expression of target mRNAs by binding to complementary sequences usually located in the 3′ untranslated region (3′UTR). However, the substantial lack of knowledge about miRNAs’ targets hinder full understanding of t...

ea0025oc3.4 | Pituitary and thyroid | SFEBES2011

PTTG promotes mitogenic mechanisms in thyroid cells through autocrine pathways of interaction with growth factors

Lewy Gregory , Ryan Gavin , Stewart Sarah , Read Martin , Smith Vicki , Fong Jim , Warfield Adrian , Eggo Margaret , Seed Robert , Sharma Neil , Kwan Perkin , Franklyn Jayne , McCabe Christopher , Boelaert Kristien

The human pituitary tumor transforming gene (hPTTG) is overexpressed in thyroid cancers; it induces genetic instability and propagates growth through the induction of growth factors. We investigated the pathways of interaction between hPTTG and epidermal growth factor (EGF), transforming growth factor-α (TGF-α), insulin-like growth factor 1 (IGF1) and basic fibroblast growth factor (FGF2) in vitro and in vivo. Synchronised K1 and TPC-1 papillary thyroid...

ea0025oc3.5 | Pituitary and thyroid | SFEBES2011

Metastatic characteristics and radiosensitivity of thyroid carcinoma cells depends on HIF-1 and PI3K signalling in vitro and in vivo

Burrows Natalie , Babur Muhammad , Resch Julia , Ridsdale Sophie , Williams Joseph , Brabant Georg , Williams Kaye

The transcription factor HIF-1α regulates hypoxia-mediated gene expression which promotes tumour growth, metastasis and desensitisation to chemo-and radiotherapy. HIF-1 is functional in a range of thyroid-carcinoma cells and is regulated by hypoxia and the PI3K and MAPK-signalling pathways.We aimed to determine if HIF-1 and PI3K were important in the development of a metastatic phenotype and play a role in desensitisation to radiotherapy in thyroid ...

ea0025oc3.6 | Pituitary and thyroid | SFEBES2011

Morbidity in patients with endogenous subclinical hyperthyroidism

Vadiveloo Thenmalar , Donnan Peter , Cochrane Lynda , Leese Graham

Objective: To investigate the long term outcomes for patients with endogenous subclinical hyperthyroidism (SH).Design: Population record-linkage technology was used retrospectively to identify patients with SH and hospital admissions from January 1, 1993 to December 31, 2009.Patients: All residents over 18 years old with at least two serum TSH measurements below the reference range for at least 4 months apart and normal free T...

ea0025oc3.7 | Pituitary and thyroid | SFEBES2011

Thyroid dysfunction and clot structure: a mechanism for increased thrombotic risk in hyperthyroid individuals?

Hooper Jonathan , Orme Steve , van Zaane Bregje , Hess Katharina , Alzahrani Saad , Standeven Kristina , Pearce Simon , Grant Peter , Ajjan Ramzi

Hyperthyroidism is associated with increased thrombotic risk through mechanisms that are not fully understood. In contrast, a tendency to bleeding has been reported in hypothyroidism. Fibrin network structure has been shown to determine susceptibility to atherothrombosis and venous thrombotic events and therefore, this study investigates the effects of thyroid-dysfunction on clot structure and fibrinolysis using longitudinal interventional studies.Sevent...

ea0025oc3.8 | Pituitary and thyroid | SFEBES2011

Assessment of the UK iodine status: a National Survey

Vanderpump Mark , Lazarus John , Smyth Peter , Burns Robert , Eggo Margaret , Han Thang , Williams Graham , Torlinska Barbara , Mullan Karen , Pearce Simon , Razvi Salman , Lean Mike , Aspray Emile Combet , Bannon Denise , Abraham Prakash , Vadia Bijay , Leese Graham , Laurberg Peter , Boelaert Kristien , Franklyn Jayne

Inadequate dietary iodine intake is the most common cause of preventable mental impairment worldwide and is defined by the WHO as a population median urinary iodine (UI) excretion <100 μg/l. No contemporary data are available for the UK according to the ICCIDD. The UK has no programme of food/salt iodination.We have performed a systematic assessment of the current UK iodine status in 14–15 years old schoolgirls. Seven hundred and eighty-fiv...