Searchable abstracts of presentations at key conferences in endocrinology

ea0073yi7 | Young Investigator Awards | ECE2021

Alterations in clock genes expression in eutopic and ectopic endometrial tissue

Karapanagioti Angeliki , Narjes Nasiri-Ansari , Mavrogianni Despoina , Randeva Harpal , Papavassiliou Athanasios G. , Drakakis Peter , Kassi Evanthia

IntroductionEndometriosis is a dysplastic disease affecting approximately 7–10% of reproductive–aged women. It is defined as the presence of endometrial-like tissue outside the uterine cavity. Disruption of circadian rhythm in night shift worker has been associated with menstrual irregularity and increased chance of developing endometriosis and ovarian tumors. The central circadian clock system located in hypothalamic suprachiasmatic nucleus (...

ea0081ep937 | Reproductive and Developmental Endocrinology | ECE2022

Melatonin ameliorates glucocorticoid-induced invasiveness and circadian rhythm disruption in human endometrial adenocarcinoma cells

Karapanagioti Angeliki , Nasiri-Ansari Narjes , Kyrou Ioannis , Mavrogianni Despoina , Drakakis Peter , kaltsas gregory , Papavassiliou Athanasios G. , Randeva Harpal , Kassi Eva

Introduction: The biological rhythm pattern is synchronized through circadian oscillation of cortisol and melatonin release. Increased cortisol levels and circadian rhythm disruption act as an oncogenic factor in endometrial cancer through among others- dysregulation of cell proliferation/apoptosis and invasion.Aim: To investigate, whether there is an oscillatory expression of the clock genes, MT1 and GR expression in human endometrial carcinoma cells. T...