Searchable abstracts of presentations at key conferences in endocrinology
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European Congress of Endocrinology 2021

22 May 2021 - 26 May 2021

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The European Congress of Endocrinology provides a global platform for the international endocrine community to discuss the latest advances in the field.

Oral Communications

Young Investigator Awards

ea0073yi1 | Young Investigator Awards | ECE2021

Circulating myomiRNAs as biomarkers of Cushing’s syndrome

Pivonello Claudia , Patalano Roberta , Negri Mariarosaria , Montò Tatiana , Amatrudo Feliciana , Paola Nicola Di , Iacono Marina , Simeoli Chiara , Ferrigno Rosario , Solari Domenico , Angelis Cristina De , Auriemma Renata Simona , Cappabianca Paolo , Colao Annamaria , Pivonello Rosario

Cushing’s syndrome (CS) is a rare endocrine disease caused by a chronic exposure to endogenous cortisol or exogenous glucocorticoids (GCs). Among multiple comorbidities, impairment of skeletal muscle mass and strength affects 40–70% of patients with active CS and persist even after long-term disease remission. In pathological conditions, GCs excess sustain muscle atrophy and weakness affecting type II muscle fibers. Muscle-specific microRNAs, defined myomiRs, are in...

ea0073yi2 | Young Investigator Awards | ECE2021

Efficacy of the Anti-BAFF monoclonal antibody belimumab vs methylprednisolone in active moderate-severe graves’ orbitopathy: Preliminary analysis of a randomized controlled trial

Vittoria Favero , Currò Nicola , Campi Irene , Lazzaroni Elisa , Covelli Danila , Vannucchi Guia , Dazzi Davide , Muller Ilaria , Minorini Valeria , Guastella Claudio , Maura Arosio , Salvi Mario

BackgroundSerum B cell stimulating factor (BAFF) has been shown to be elevated in Graves’ disease (Vannucchi 2012). In addition, BAFF and its receptor have been shown to be expressed on lymphocytes infiltrating the thyroid in Graves’ disease and also on thyrocytes (Campi 2015).AimsWe tested in a single-blind randomized controlled trial (EudraCT 2015–002127–26) whether the administration ...

ea0073yi3 | Young Investigator Awards | ECE2021

The american lifestyle induced obesity syndrome (ALIOS) diet induces an increase in intestinal permeability and exacerbates inflammation in female and male mice via the TLR4 signalling pathway

Anastasia Arvaniti , Nikolaou Nikolaos , Harris Shelley , Cox Roger , Corridoni Daniele , Xin Wei , Tomlinson Jeremy , Gathercole Laura

Non-alcoholic fatty liver disease (NAFLD) is a spectrum of disease spanning from simple steatosis to non-alcoholic steatohepatitis (NASH) with risk of progression to fibrosis and eventually cirrhosis. Dysfunction of the gut-liver axis plays a role the progression to NASH. Intestinal damage and increased permeability can increase the delivery of pathogen-associated molecular patterns (PAMPs), such as LPS and intact bacteria, to the liver where they can activate the TLR4 signall...

ea0073yi4 | Young Investigator Awards | ECE2021

Use of 11C-methionine PET-CT scanning to guide management of acromegaly following primary therapy – A pragmatic prioritisation strategy to achieve maximal cost effectiveness

Rajan Roby , Bhatt D , Philip S , Graveling AJ , Kamel M , Olson S , Mckiddie F , Gillett D , Bashari W , Gurnell M , Abraham P

Background11C-methionine (11C-Met) positron emission tomography co-registered with MRI is a new imaging technique used for functioning pituitary adenomas, permitting targeted intervention (Transphenoidal Surgery (TSS) or Radiotherapy)1. The 11C-Met PET-CT scan has been available in our centre since Dec 2016. With limited availability in 2019/2020 (due to cyclotron refurbishment) we re-audited our patients to prioritise th...

ea0073yi5 | Young Investigator Awards | ECE2021

Atlas of G protein-coupled receptors in radioiodine-refractory thyroid cancer: Novel therapeutic targets for drug repositioning?

Suteau Valentine , Valérie Seegers , Munier Mathilde , Boubaker Rym Ben , Illouz Frederic , Ghamrawi Sarah , Briet Marie , Rodien Patrice , Briet Claire

IntroductionProgressive and radioiodine-refractory thyroid cancer has poor outcomes and limited therapeutic options (i.e tyrosine kinase inhibitors) due to the transient efficacy of treatment and toxic effects. Therefore, combinatorial treatment with new therapeutic approaches are needed. Many studies link G Protein-Coupled Receptors (GPCRs) to cancer. The aim of this study is to present the first specific atlas of GPCRs expression in progressive and ref...

ea0073yi6 | Young Investigator Awards | ECE2021

Unveiling the pathophysiological relationship between prostate cancer and obesity: miR-107 as a novel personalized diagnostic and therapeutic tool

Prudencio Sáez-Martínez , Vicente Herrero-Aguayo , Juan M. Jiménez-Vacas , Trinidad Moreno-Montilla , Julia Carrasco-Valiente , André Sarmento-Cabral , José López-Miranda , Enrique Gómez-Gómez , Manuel D. Gahete , Raúl M. Luque

Prostate cancer (PCa) is one of the most common causes of cancer-related deaths in men worldwide. Therefore, more specific and non-invasive diagnostic biomarkers as well as novel therapeutic targets are urgently needed. As miRNAs have been proposed as promising elements for the identification of novel diagnostic and therapeutic tools for different pathologies, including cancer, we investigated the miRNA landscape in PCa and explored their putative diagnostic/therapeutic utilit...

ea0073yi7 | Young Investigator Awards | ECE2021

Alterations in clock genes expression in eutopic and ectopic endometrial tissue

Karapanagioti Angeliki , Narjes Nasiri-Ansari , Mavrogianni Despoina , Randeva Harpal , Papavassiliou Athanasios G. , Drakakis Peter , Kassi Evanthia

IntroductionEndometriosis is a dysplastic disease affecting approximately 7–10% of reproductive–aged women. It is defined as the presence of endometrial-like tissue outside the uterine cavity. Disruption of circadian rhythm in night shift worker has been associated with menstrual irregularity and increased chance of developing endometriosis and ovarian tumors. The central circadian clock system located in hypothalamic suprachiasmatic nucleus (...

ea0073yi8 | Young Investigator Awards | ECE2021

Metformin and simvastatin in combination: drugs repositioning to impair high-grade astrocytomas progression

Fuentes-Fayos Antonio C. , Garcia Garcia Miguel , Jiménez-Vacas Juan M , Martin-Colom Julia , Doval-Rosa Carlos , Blanco-Acevedo Cristobal , Gahete Ortiz Manuel , Castaño Justo P. , Juan Solivera , Luque Raul M.

Astrocytomas are a subtype of malignant gliomas characterized by rapid growth and high diffusion through the brain. Based on the agresiveness features, they are stratified from low grades (I and II) to high grades (HGAs; III and IV), being grade-IV [glioblastoma multiforme (GBM)] the most aggressive and one of the most common malignant cancers in the brain, with an overall survival from diagnosis of ~14 months. Current standard therapies to treat HGAs are not efficient and the...

ea0073yi9 | Young Investigator Awards | ECE2021

The value of liquid and solid mixed meal tests to diagnose postprandial reactive hypoglycaemic syndrome

Frederique Van de Velde , Helleputte Simon , Arsène-Hélène Batens , Nieuwenhove Yves Van , Lapauw Bruno

BackgroundPrecise diagnostics for postprandial reactive hypoglycaemic syndrome (PRHS) after gastric bypass surgery (GBS) are lacking. Oral glucose tolerance tests are advocated but might cause early dumping in this population and often cause hypoglycaemic values in a normal population.AimTo evaluate glycaemic responses during liquid and solid mixed meal tolerance tests (LMMTT and SMMTT) in a post-GBS populati...

ea0073yi10 | Young Investigator Awards | ECE2021

Placental expression of neurokinin B and its receptor NK3R is increased in women with polycystic ovary syndrome: results of a preliminary study

Markantes Georgios , Markatos Fotios , Georgopoulos Neoklis

BackgroundWomen with polycystic ovary syndrome (PCOS) are at increased risk of pregnancy complications and poor pregnancy outcomes. Defective placentation is among the proposed mechanisms involved. Altered neurokinin B (NKB) placental expression has been associated with several conditions characterized by placental dysfunction, such as pre-eclampsia and intra-uterine growth retardation. However, the expression of NKB and its receptors has not been studie...

ea0073yi11 | Young Investigator Awards | ECE2021

Gβγ-mediated signaling regulates NIS abundance at the plasma membrane

Márcia Faria , João Bugalho Maria , Paulo Matos , Luísa Silva Ana

IntroductionThe Sodium Iodide Symporter (NIS) is responsible for the active transport of iodide into thyroid cells. Most of differentiated thyroid carcinomas (TC) retain the functional expression of NIS, which allows the use of radioiodide (RAI) as the systemic treatment of choice for metastatic disease. Still, a significant proportion of patients with advanced thyroid cancer fail to respond to RAI therapy (refractory-TC), which makes their management ve...

ea0073yi12 | Young Investigator Awards | ECE2021

Preoperative predictors and prognostic factors of recurrence of the parathyroid carcinoma – Data of a multi-center study

Krupinova Julia , Voronkova Iya , Aynetdinova Alina , Pigarova Ekaterina , Mokrysheva Natalia

BackgroundThere are no specific markers for parathyroid carcinoma (PC) therefore, the development of algorithms for identifying high-risk patients is an urgent task.AimsTo determine clinical and laboratory predictors of PC and identify the factors of a poor prognosis.Materials and methodsA multi-center retrospective study included 242 patients with primary hyperpa...