Endocrine Abstracts

BackgroundObesity is closely associated with impaired adipose tissue function. Although bariatric surgery is the treatment of choice for severe obesity and its related conditions, there are conflicting data on the reversal of adipose tissue dysfunction after surgery-induced weight loss. We hypothesise that local steroid hormone availability influences fat deposition or mobilisation and that these changes track with weight loss improvements, because plasm...

BackgroundCentral hypothyroidism (CeH) is a rare condition affecting approximately 1:16000 – 100 000 individuals. Congenital forms can harm the normal development if not detected and treated promptly. The clinical and biochemical diagnosis especially of the isolated CeH can be challenging. The cases are not usually detected in the neonatal screening, which, in most countries, are focused on detection of the more prevalent primary hypothyroidism. Unt...

Pheochromocytoma and Paraganglioma, collectively referred to as PPGLs, are rare, mostly benign neuroendocrine tumors arising from chromaffin cells of the adrenal gland or of extra-adrenal sites, respectively. Surgery is the first-line therapy for localized PPGLs. However, up to 17% of PPGLs show metastatic spread, and for these cases there is no curative treatment. Therefore, the identification of novel therapeutic approaches for advanced PPGLs is highly clinically relevant. W...

Long-acting somatostatin receptor ligands (LA-SRLs) are a first line medical treatment for acromegaly but require monthly parenteral administration. Paltusotine (CRN00808) is a nonpeptide, small molecule somatostatin type 2 (SST2) receptor agonist with high oral bioavailability (70%), suitable for once daily, oral dosing. The recently reported results of the ACROBAT Edge study (NCT03789656) suggest that patients with acromegaly treated with injected SRLs can switch to once dai...

Thyroid hormones play an essential role for the embryonal development of the cardiovascular system including its central control mechanisms. Particularly the latter critically depends on maternal thyroid hormone, as the embryo doesn’t produce own thyroid hormone until late in pregnancy. However, the precise window of action has remained undetermined, and it is therefore unclear whether alterations in maternal thyroid hormone directly affect the offspring’s cardiac fu...

IntroductionThe development of Diabetes mellitus type 1 (DMT1) is considered as an autoimmune pro-inflammatory process. Human enteroviruses are thought to be also a cause. These viruses influence beta cells and cause expression of immunological factors. The affected cells destroy the related beta cells. The aim of the work is to study the genetic polymorphisms in IP-10/CXCL10 and its receptors CXCR3 and TLR4 in order to predict expression of DMT1.<p ...