Searchable abstracts of presentations at key conferences in endocrinology

ea0015s17 | Hypoxia: its effects on physiology and pathophysiology | SFEBES2008

Hypoxia signalling and VHL

Maxwell Patrick

VHL is a classical two-hit tumor suppressor. Tumors in the familial syndrome involve somatic inactivation of the second allele, while most sporadic clear cell renal cell carcinomas and a proportion of phaeochromocytomas also exhibit biallelic inactivation of VHL. VHL disease is subclassified based on the risk of renal cell carcinoma, haemangioblastoma and phaeochromocytoma.The best-characterised function of VHL is regulation of Hypoxia-Indu...