Endocrine Abstracts

Obesity is a chronic disease associated with a number of co-morbidities. Management options include lifestyle changes, pharmacotherapy and bariatric surgery. European guidelines recommend the use of pharmacotherapy for BMI ≥30 kg/m2 or BMI ≥27 kg/m2 with comorbidities in adjunct to lifestyle modification. Until 2015, orlistat was the only available medication for the treatment of obesity in Europe. Since then, further pharmacological agents ha...

Obesity is a chronic disease associated with a number of co-morbidities. Management options include lifestyle changes, pharmacotherapy and bariatric surgery. European guidelines recommend the use of pharmacotherapy for BMI ≥30 kg/m2 or BMI ≥27 kg/m2 with comorbidities in adjunct to lifestyle modification. Until 2015, orlistat was the only available medication for the treatment of obesity in Europe. Since then, further pharmacological agents ha...

Bariatric surgery is a well established treatment for obesity and its associated co-morbidities. Many obese patients undergoing bariatric surgery have pre-existing micronutrient deficiencies which can potentially worsen post-bariatric surgery. Pre- and post- surgical nutritional monitoring and follow-up of these patients is imperative as part of long term bariatric care. This lecture will review common nutritional deficiencies post-bariatric surgery, and current guidelines for...

Objective: A case study that demonstrates the importance of thorough psychiatric assessment, intervention and follow-up in morbidly obese patients presenting for Bariatric surgery and risk of addiction transfer.Background: Positive correlation between psychiatric disorders and obesity is documented. Cases of addiction transfer have been reported complicating outcome post Bariatric Surgery.Case description: A 29 year old Caucasian f...

Introduction: Advances in the understanding of the natural history and genetics of phaechromocytomas and paragangliomas have altered the demographics of these conditions resulting in much higher rates of malignancy and association with known genetic abnormalities.Objective: To analyse the clinical and biochemical features of hereditary (H) and sporadic (S) phaeochromocytomas and paragangliomas.Design: Retrospective case-series at G...

Aim: Anti-thyroid treatment with carbimazole or propylthiouracil is the first-line treatment for autoimmune thyrotoxicosis in the UK. Following 12–18 months treatment there is a significant relapse rate (at least 50%). This study analysed the demographics and clinical features of 100 patients with relapsed thyrotoxicosis to examine which variables are predictive of relapse.Methods: This retrospective study included adult patients identified using ou...

Case history: A 26 year old female with severe gastro-oesophageal reflux disease was seen in our service for assessment prior to roux-en-Y gastric bypass (RYGB) surgery for this condition. She had additional history of obesity, hypertension, insomnia, cholecystectomy for gallstones and anxiety-depression. At age 18 her weight was 85 kg, BMI 28 kg/m2. She gained 40 kg over the subsequent 8 years and in clinic was 123 kg, BMI 41.1 kg/m2 with a gynaecoid pat...

Background: Bariatric surgery is considered the most effective tool to manage the growing pandemic of obesity related health disorders. Lack of regular surveillance following bariatric procedures can put patients at risk of developing serious micro-nutritional deficiencies and related complications.Case report: A 51-year-old lady presented to the bariatric services in 2015 with long standing neurological symptoms including memory and cognitive impairment...

Introduction: Primary hyperaldosteronism (PHA) accounts for 5–13% of all hypertension and up to 20% of resistant hypertension. Aldosterone producing adenomas (APA) account for 60% of PHA and surgical resection in these patients can be curative. There is no consensus on the need for and duration of follow-up after adrenalectomy. This study assessed the immediate effect of unilateral adrenalectomy for APA on the serum potassium, renin and aldosterone levels. Acute effects o...

Introduction: Gestational diabetes mellitus (GDM) is an important co-morbidity of pregnancy, with insulin resistance a key contributor in its underlying pathology. Relaxin is a hormone considered crucial for mediating adaptations deemed vital for maintenance of pregnancy. Evidence has suggested that levels of plasma relaxin may be positively correlated with insulin sensitivity. This led us to hypothesize that relaxin may play a role in the pathogenesis of insulin resistance in...