Searchable abstracts of presentations at key conferences in endocrinology

ea0026p16 | Adrenal cortex | ECE2011

Potential role of mast cells in the physiopathology of aldosterone-producing adenoma

Duparc Celine , Moreau Lucile , Perraudin Veronique , Gobet Francoise , Meatchi Tchao , Plouin Pierre-Francois , Zennaro Maria-Christina , Louiset Estelle , Lefebvre Herve

We have shown that 5-hydroxytryptamine (5-HT) receptor type 4 (5-HT4R) agonists stimulate aldosterone production in patients with aldosterone-producing adenoma (APA). Moreover, 5-HT-positive cells were observed in APA tissues and 5-HT4R mRNAs were markedly overexpressed in APAs in comparison with normal adrenals. All these results suggested that 5-HT produced by adrenal mast cells could be involved in the physiopathology of APAs. The aim of this work was to investigate the rol...

ea0099ep13 | Adrenal and Cardiovascular Endocrinology | ECE2024

Implication of serotonin in the physiopathology of aldosterone-producing adenoma

Duparc Celine , D'Agostino Margot , Lopez Antoine-Guy , Renouf Sylvie , Manceau Gilles , Meatchi Tchao , Amar Laurence , Louiset Estelle , Lefebvre Herve

In the human adrenal gland, serotonin (5-HT), released by subcapsular mast cells strongly stimulates aldosterone production via activation of the type 4 serotonin receptor (5-HT4R). Consistently, plasma aldosterone levels increase after administration of 5-HT4R agonists like cisapride to healthy volunteers. Previous studies performed in aldosterone producing adenomas (APA) have shown an increase in mast cells density and an overexpression of HTR4 gene, encoding 5-HT4R...

ea0049gp15 | Adrenal 2 | ECE2017

Integrated genomic and phenomic analysis reveals key molecular pathways of aldosterone producing adenoma

Fernandes-Rosa Fabio , Boulkroun Sheerazed , Dzib Felipe Golib , Daniil Georgios , Amar Laurence , Rance Bastien , Samson-Couterie Benoit , Jeunemaitre Xavier , Meatchi Tchao , Benecke Arndt , Strom Tim , Zennaro Maria-Christina

Primary aldosteronism is the most common form of secondary hypertension. Somatic mutations in KCNJ5, ATP1A1, ATP2B3 and CACNA1D have been described in 50% of aldosterone producing adenomas (APA). To identify genetic alterations in new genes, we performed whole exome sequencing in 23 patients with APA negative for recurrent mutations in known driver genes. A low number of somatic variations were identified per patient, ranging from 1 to 22. N...