Abstract Search

ea0049ep802 | Nuclear receptors and Signal transduction | ECE2017

5α-THB as a novel anti-inflammatory drug: The roles of the glucocorticoid and mineralocorticoid receptors

Abernethie Amber , Gastaldello A , Morgan RA , Mitchell C , McInnes KJ , Beck K , Odermatt A , Houtman R , Melchars D , Meijer OC , Hadoke PWF , Livingstone DEW , Walker BR , Andrew R

Glucocorticoids (GC) are potent anti-inflammatory compounds, acting mainly through the glucocorticoid receptor (GR). GC therapy, however, has debilitating side-effects, necessitating safer new alternative therapies. The natural GC metabolite 5α-Tetrahydrocorticosterone (5αTHB) is anti-inflammatory in vivo in mice, but with fewer side-effects. Its mechanism of action is unknown, and here we test signalling via GR and the mineralocorticoid receptor (MR). 5&#94...

ea0070oc2.4 | Bone and Calcium | ECE2020

Loss of glucocorticoid rhythm induces an osteoporotic phenotype in mice

Winter Elizabeth M , Schilperoort M , Kroon J , Kooijman S , Mletzko K , Busse B , Pereira AM , Appelman-Dijkstra NM , Bravenboer N , Rensen PCN , Meijer OC

Introduction: Glucocorticoid (GC)-induced osteoporosis is a widespread problem that is accompanied with increased fracture risk. Currently, it is unknown whether detrimental effects of GC therapy on bone are simply the consequence of supraphysiological GC doses, or whether absence of the endogenous GC rhythm also plays a role. In this study, we aimed to elucidate the importance of the presence of a diurnal corticosterone (CORT) rhythm, the primary GC in mice, for bone quality....

Endocrine Abstracts

5α-THB as a novel anti-inflammatory drug: The roles of the glucocorticoid and mineralocorticoid receptors

Loss of glucocorticoid rhythm induces an osteoporotic phenotype in mice

BiosciAbstracts