Searchable abstracts of presentations at key conferences in endocrinology

ea0063s18.2 | Congenital hypogonadotropic hypogonadism: New insights into GnRH Regulation | ECE2019

Flipping the GnRH switch with microRNAs

Messina Andrea

A sparse population of a few hundred primarily hypothalamic neurons forms the hub of a complex neuroglial network that controls reproduction in mammals by secreting the ‘master molecule’, gonadotropin-releasing hormone (GnRH). Both the Kisspeptin input on GnRH neurons and timely changes in GnRH expression are necessary for the onset of puberty. However, the exact molecular mechanisms underlying this process remain elusive. Here, we report that a dramatic inversion in...

ea0070aep788 | Reproductive and Developmental Endocrinology | ECE2020

Clinical and genetic overlap between congenital hypogonadotropic hypogonadism and cornelia de lange syndrome

Xu Cheng , Messina Andrea , Acierno James , Niederlander Nicolas , Santoni Federico , Papadakis Georgios , Pignatelli Duarte , Avbelj Stefanija Magdalena , Keefe Kimberly , Balasubramanian Ravikumar , Crowley William , Pitteloud Nelly

Background: Congenital hypogonadotropic hypogonadism (CHH), a clinically and genetic heterogenous sydrome, is caused by > 40 known loci whose mutations share the ability to cause defects in the ontogeny of the GnRH neuron network leading to absent/incomplete puberty and infertility. Cornelia de Lange Syndrome (CdLS) is similarly heterogenous disorder (distinctive facies, psychomotor delay, growth retardation and upper limb malformation) caused by mutations in 7 different g...

ea0081rc12.4 | Rapid Communications 12: Reproductive and Developmental Endocrinology | ECE2022

Unraveling the link between metabolism and reproduction in obese men

Papadakis Georgios , Lucie Favre , Zouaghi Yassine , Vionnet Nathalie , Niederlander Nicolas , Adamo Michela , Acierno James , Santoni Federico , Berdous Dassine , Spoerl Alexia , Paccou Emmanuelle , Aleman Yasser , Salamin Olivier , Hagmann Patrick , Messina Andrea , Pitteloud Nelly

Introduction: Obesity is a worldwide pandemic, and in men can often be associated with hypogonadotropic hypogonadism (HH), a finding consistent with a clear link between sex steroids and reproduction. In this study, we aimed to characterize the phenotypic spectrum of male obesity, focusing on the metabolic and reproductive effect of weight loss after bariatric surgery, as well as to explore the role of central inflammation.Methods: We conducted an observ...