Searchable abstracts of presentations at key conferences in endocrinology

ea0081oc6.1 | Oral Communications 6: Endocrine-Related Cancer | ECE2022

Recurrent disease in patients with sporadic pheochromocytoma and paraganglioma

Li Minghao , Prodanov Tamara , Meuter Leah , Kerstens Michiel , Bechmann Nicole , Prejbisz Aleksander , Fassnacht Martin , Timmers Henri , Beuschlein Felix , Fliedner Stephanie , Robledo Mercedes , Lenders Jacques , Pacak Karel , Eisenhofer Graeme , Pamporaki Christina

Background: It is well established that life-long follow-up is required for patients with hereditary pheochromocytomas and paragangliomas (PPGLs), due to the potential of developing recurrent disease. However, whether follow-up of patients with sporadic PPGLs is necessary, remains unclear.Aims: To examine the prevalence and predictors of recurrent disease in patients with sporadic PPGLs.Materials and method: This multicenter study included retrospective ...

ea0081oc13.6 | Oral Communications 13: Adrenal and Cardiovascular Endocrinology 2 | ECE2022

Machine Learning models for the accurate prediction of malignant pheochromocytomas and paragangliomas

Pamporaki Christina , Berends Annika MA , Filippatos Angelos , Prodanov Tamara , Meuter Leah , Prejbisz Aleksander , Beuschlein Felix , Fassnacht Martin , Timmers Henri , Noelting Svenja , Abhyankar Kaushik Ganesh , Contsantinescu Georgiana , Kunath Carola , Wang Katharina , Remde Hanna , Januszewicz Andrzej , Robledo Mercedes , Lenders Jacques , Kerstens Michiel , Pacak Karel , Eisenhofer Graeme

Introduction: Pheochromocytomas and paragangliomas (PPGLs) exhibit an up to 20% malignancy rate. Various clinical, genetic, and pathological features have been proposed as predictors of malignancy. However, until present there are no robust indices to reliably predict metastatic PPGLs.Aim: The aim of the present study was to prospectively validate the value of methoxytyramine as risk marker of metastatic disease and establish a machine learning (ML) mode...

ea0089c27 | Clinical – Nuclear Medicine/Interventional Radiology/Imaging | NANETS2022

Performance of 68Ga-DOTATATE PET/CT, 18F-FDG PET/CT, CT, and MRI Spine in the Detection of Spinal Bone Metastases in Metastatic Pheochromocytoma/Paraganglioma

Jha Abhishek , Patel Mayank , Saboury Babak , Millo Corina , Ling Alexander , Shah Ritu , Chen Clara C. , Meuter Leah , Talvacchio Sara , Knue Marianne , Lin Frank I. , O'Sullivan Coyne Geraldine , Chen Alice P. , Nilubol Naris , Herscovitch Peter , Taieb David , Cahid Civelek Ali , Carrasquillo Jorge A. , Pacak Karel

Background: To evaluate and compare the diagnostic performance of 68Ga-DOTATATE PET/CT to 18F-FDG PET/CT, CT of neck, chest, abdomen and pelvis (CT), and MRI of cervical, thoracic, and lumbar spine (MRI spine), for the detection of spinal bone metastases in metastatic pheochromocytoma and/or paraganglioma (PPGL).Methods: Between 2014 and 2019, 41 consecutive metastatic PPGL patients (19 females; mean age, 43 years) underwent 68...