Searchable abstracts of presentations at key conferences in endocrinology
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European Congress of Endocrinology 2022

Milan, Italy
21 May 2022 - 24 May 2022

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The 24th European Congress of Endocrinology (ECE) and the Italian Society of Endocrinology look forward to welcoming you to Milan. ECE 2022 returns for a four day, six parallel session festival of endocrine science. You can join us In person in Milan, Italy OR Live @Home online!

Oral Communications

Oral Communications 13: Adrenal and Cardiovascular Endocrinology 2

ea0081oc13.1 | Oral Communications 13: Adrenal and Cardiovascular Endocrinology 2 | ECE2022

Development of [18F]AldoView as the first highly selective aldosterone synthase PET tracer for imaging of patients with primary hyperaldosteronism

Sander Kerstin , Kurzawinski Tom , Gendron Thibault , Cybulska Klaudia , Sirindil Fatih , Zhou Junhua , Kalber Tammy , Lythgoe Mark , Brown Morris , Williams Bryan , Arstad Erik

Background: Inappropriately high aldosterone in patients with primary hyperaldosteronism (PHA) is due to increased aldosterone synthase (CYP11B2) activity. Selective in vivo imaging of overexpressed CYP11B2 in adrenals with positron emission tomography (PET) has not yet been achieved due to close homology of enzymes involved in aldosterone and cortisol (CYP11B1) synthesis.Aim: Synthesize a fluorine-18 labelled highly selective CYP11B2 inhibitor, [18...

ea0081oc13.2 | Oral Communications 13: Adrenal and Cardiovascular Endocrinology 2 | ECE2022

Early post-operative ACTH-stimulated aldosterone predicts long-term biochemical outcome in primary aldosteronism

Bruedgam Denise , Adolf Christian , Schneider Holger , Wegmann Verena , Schwarzlmueller Paul , Mueller Lisa , Holler Finn , Lechner Benjamin , Handgriff Laura , Ladurner Roland , Deniz Sinan , Williams Tracy Ann , Beuschlein Felix , Reincke Martin , Heinrich Daniel

Introduction: Primary aldosteronism (PA) is the most common surgically curable cause for endocrine hypertension. Patients with unilateral aldosterone-producing adenoma undergo adrenalectomy (ADX). Clinical and biochemical outcome is assessed 6-12 months after ADX according to PASO consensus. To reduce unnecessary follow-up visits and change in medication for diagnostic purposes for potentially cured patients after ADX, a prediction tool is needed. Previous research had shown g...

ea0081oc13.3 | Oral Communications 13: Adrenal and Cardiovascular Endocrinology 2 | ECE2022

11-oxygenated C19 steroids are the predominant androgens responsible for hyperandrogenemia in Cushing’s disease

Nowotny Hanna , Vogel Frederick , Bidlingmaier Martin , Braun Leah , Reincke Martin , Tschaidse Lea , Auer Matthias , Lottspeich Christian , Hawley James M , Adaway Jo , Keevil Brian , Schilbach Katharina , Reisch Nicole

Background: Symptoms of hyperandrogenism are common in patients with CushingÂ’s disease (CD), but they cannot be sufficiently explained by measured concentrations of circulating androgens. In this study we analyzed the contribution of 11-oxygenated (11o×C19) androgens to hyperandrogenemia in female patients with CD as well as the influence of treatment with steroidogenesis inhibitors osilodrostat and metyrapone on 11o×C19 and classic androgens.<p class="abste...

ea0081oc13.4 | Oral Communications 13: Adrenal and Cardiovascular Endocrinology 2 | ECE2022

Classic and 11-oxygenated androgens in serum and saliva across adulthood and the menstrual cycle – a mass spectrometry-based cross-sectional study

Kempegowda Punith , Schiffer Lina , Adaway Jo , Shaheen Fozia , Ebbehoj Andreas , Singh Sumitabh , Prete Alessandro , Hawley James M , Sitch Alice J , Keevil Brian , Bancos Irina , Taylor Angela , Arlt Wiebke

Objective: Quantify classic and 11-oxygenated androgens in serum and saliva and determine variations across age, sex, body mass index (BMI), menstruation and hormonal contraception use.Methods: Morning serum samples were collected from 292 healthy volunteers (125 men, 22-95 years; 167 women, 21-91 years). Morning saliva was collected from 83 healthy volunteers (51 women, 32 men). 25 individuals (12 women, 13 men) also collected a 7-timepoint diurnal sali...

ea0081oc13.5 | Oral Communications 13: Adrenal and Cardiovascular Endocrinology 2 | ECE2022

Machine learning-based texture analysis in the characterization of cortisol secreting vs non secreting adrenocortical incidentalomas in CT scan

Maggio Roberta , Messina Filippo , D'Arrigo Benedetta , Maccagno Giacomo , Lardo Pina , Palmisano Claudia , Biondo Irene , Matarazzo Iolanda , Laghi Andrea , Pugliese Giuseppe , Stigliano Antonio

Adrenal nodular disease is a frequently increasing in the general population with an incidence that reaches almost 10% in the seventh decade of life. More and more evidences show these lesions discovered through diagnostic imaging (CT, MRI) performed for other medical problems (incidentalomas). New radioimaging techniques, exploiting the quantitative variables of imaging, permit to identify an hypothetical pathological tissue. We have applied this potential in a retrospective ...

ea0081oc13.6 | Oral Communications 13: Adrenal and Cardiovascular Endocrinology 2 | ECE2022

Machine Learning models for the accurate prediction of malignant pheochromocytomas and paragangliomas

Pamporaki Christina , Berends Annika MA , Filippatos Angelos , Prodanov Tamara , Meuter Leah , Prejbisz Aleksander , Beuschlein Felix , Fassnacht Martin , Timmers Henri , Noelting Svenja , Abhyankar Kaushik Ganesh , Contsantinescu Georgiana , Kunath Carola , Wang Katharina , Remde Hanna , Januszewicz Andrzej , Robledo Mercedes , Lenders Jacques , Kerstens Michiel , Pacak Karel , Eisenhofer Graeme

Introduction: Pheochromocytomas and paragangliomas (PPGLs) exhibit an up to 20% malignancy rate. Various clinical, genetic, and pathological features have been proposed as predictors of malignancy. However, until present there are no robust indices to reliably predict metastatic PPGLs.Aim: The aim of the present study was to prospectively validate the value of methoxytyramine as risk marker of metastatic disease and establish a machine learning (ML) mode...