Searchable abstracts of presentations at key conferences in endocrinology
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European Congress of Endocrinology 2022

Milan, Italy
21 May 2022 - 24 May 2022

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The 24th European Congress of Endocrinology (ECE) and the Italian Society of Endocrinology look forward to welcoming you to Milan. ECE 2022 returns for a four day, six parallel session festival of endocrine science. You can join us In person in Milan, Italy OR Live @Home online!

Oral Communications

Oral Communications 14: Late Breaking

ea0081oc14.1 | Oral Communications 14: Late Breaking | ECE2022

Expression of luteinizing hormone-chorionic gonadotrophin receptor in pheochromocytomas

Lopez Antoine-Guy , Duparc Celine , Renouf Sylvie , Machevin Elise , Guillou Vincent Le , Sabourin Jean-Christophe , Defortescu Guillaume , Buffet Alexandre , Gimenez-Roqueplo Anne-Paule , Dubessy Christophe , Louiset Estelle , Herve Lefebvre

Pheochromocytomas and paragangliomas (PPGL) are catecholamine-producing neuroendocrine tumors that display the highest heritability rate among all human tumors. Genomic analyses revealed the existence of 2 main clusters of PPGL, i.e. cluster 1 containing SDHx- and VHL-mutated tumors which do not produce epinephrine, and cluster 2 including epinephrine-secreting PPGL related to RET, NF1, TMEM127 and MAX mutations. Early diagnosis and treatment of PPGL is crucial to prevent adre...

ea0081oc14.2 | Oral Communications 14: Late Breaking | ECE2022

Peripheral facial paralysis as first manifestation of hypophysary glioma: a case report

Maria Telles Jessica , Boas Laura Vilas , Cardoso da Silva Thielsen , Andrusko dos Santos Gabrielle , Rosales Matheus Kowal , Melquiades da Rocha Bruno , Paulino Ribeiro Gama Mirnaluci

Introduction: Low-grade pituitary gliomas are extremely rare neoplasms, originating from the pituicytes of the posterior pituitary or infundibulum. The incidence of these tumors increases with age and peaks in the seventh decade of life. Gliomas are primary brain tumors of the supporting glial cells of the central nervous system, which derive from neuroglial stem cells or progenitor cells. They are responsible for nearly 30% of all primary brain tumors and 80% of all malignant...

ea0081oc14.3 | Oral Communications 14: Late Breaking | ECE2022

Are the neutrophil-to-lymphocyte ratio and large unstained cells (LUCs) different in hospitalized patients COVID-19 PCR positive with and without diabetes mellitus?

Keskin Muge , Burcak Polat Şefika , Ates Ihsan , Izdes Seval , Guner Hatice Rahmet , Topaloglu Oya , Ersoy Reyhan , Cakir Bekir

Objectives: The novel coronavirus disease-2019 (COVID-19) is the fastest-spreading disease worldwide, with over 380 million cases and 5 million deaths. The presence of diabetes mellitus (DM) in patients with COVID-19 was associated with mortality, acute respiratory distress syndrome, disease progression. COVID-19 was progressed with some hematological disorders, especially lymphopenia. Studies implicated that neutrophil-to-lymphocyte ratio (NLR) level can be a reliable marker ...

ea0081oc14.4 | Oral Communications 14: Late Breaking | ECE2022

Discovery of microRNA biomarkers in circulation and bone tissue from a type-2 diabetes mellitus rat model under different anti-osteoporotic treatments

Vazquez David Carro , Emini Lejla , Rauner Martina , Hofbauer Christine , Grillari Johannes , Eastell Richard , Hofbauer Lorenz C , Hackl Matthias

Metabolic changes in Type-2 Diabetes-Mellitus (T2DM) make patients more prone to develop osteoporosis and delayed bone healing. We hypothesize that microRNAs could be involved in the underlying mechanism and used as biomarkers in this context. To test this hypothesis, we analyzed microRNAs in samples from Zucker Diabetic Fatty (ZDF) rats, a T2DM model with reduced bone healing and bone mass. 11-week-old male ZDF and wildtype rats with a femur subcritical defect were treated wi...

ea0081oc14.5 | Oral Communications 14: Late Breaking | ECE2022

The effect of multiple passes to the same thyroid nodule in the fine needle aspiration biopsy session on obtaining adequate and/or the AUS/FLUS cytological result

Dellal Kahramanca Fatma Dilek , Cuhaci Seyrek Fatma Neslihan , Alkan Afra , Topaloglu Oya , Ersoy Reyhan , Cakir Bekir

Aim: To determine whether multiple fine needle passes to the same thyroid nodule in the fine needle aspiration biopsy (FNA) session affect sufficient and/or atypia of undetermined significance/follicular lesion of undetermined significance (AUS/FLUS) cytological result.Materials and Methods: Ultrasonography (US) and cyto-histopathology results of the nodules of patients who were diagnosed with thyroid nodules and underwent FNA between May-August 2021 wer...

ea0081oc14.6 | Oral Communications 14: Late Breaking | ECE2022

Engaging the Endocannabinoid System in Neuroendocrine Neoplasms (NENs) potentiates treatment outcomes and null drug resistance

Avniel- Polak Shani , Polak David , Oleinikov Kira , Gross David J , Wald Ori , Izhar Uzi , Mazeh Haggi , Drier Yotam , Glasberg Simona

Introduction: Patients with unresectable NENs are offered a variety of non-curable therapeutic options, which eventually fail due to drug resistance. Increasing evidence suggest an anticancer trait of cannabinoids, via cellular pathways including mTOR, known to be associated with drug resistance development. Still, limited data exist on the anti-cancer effects of cannabinoids in NENs.Aims: To understand the possible anti-tumor role of the cannabinoids an...