Endocrine Abstracts

Introduction: Giant pheochromocytomas (PCs) are adrenal tumors greater than 7 cm. The incidence and presentation of these large tumors is not well known, with only a few case reports published in literature. The preoperative and surgical management of giant PCs is also not well established.Material and methods: A retrospective monocentric study at a tertiary center of 80 consecutive patients operated for a PC between 1988 and 2018....

Objectives: Surgery of pheochromocytomas (PC) still carries a high risk of hemodynamic complications during the perioperative period. We aimed to evaluate the influence of their secretory phenotype and preoperative alpha-blocker treatment on surgical outcome.Design: A retrospective monocentric study at a tertiary medical center.Patients: 80 consecutive patients operated for an adrenal PC between 1988 and 2018.<p class="abstext"...

Caveolin-1 (cav1) is a member of the thyroxisome multiprotein complex required for thyroid hormones synthesis which is decreased in Hashimoto’s thyroiditis (HT) and excessive in Graves’ disease (GD). Both pathologies are characterized by oxidative stress (OS), the production of reactive oxygen species (ROS) exceeding the antioxidant defenses. The aim of this study is to correlate cav1 expression and OS in HT and GD. Primary cultures of human thyrocytes were treated o...