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44th Annual Meeting of the European Thyroid Association (ETA) 2022

Brussels, Belgium
10 Sep 2022 - 13 Sep 2022

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Oral Presentations

Oral Session 5: Autoimmunity

ea0084op-05-22 | Oral Session 5: Autoimmunity | ETA2022

Update on the role of caveolin-1 in cell homeostasis and oxidative stress in hashimoto’s thyroiditis and graves’ disease

Many Marie-Christine , Daumerie Chantal , Boschi Antonella , lelio baldeschi , Michel Mourad , Lengele Benoit , Catherine Behets , Marique Lancelot , Van Regemorter Victoria , Alexis Werion , Regemorter Elliott Van , Michael Hepp , Bournonville Marc de , Ville de Goyet Christine de , Craps Julie

Caveolin-1 (cav1) is a member of the thyroxisome multiprotein complex required for thyroid hormones synthesis which is decreased in Hashimoto’s thyroiditis (HT) and excessive in Graves’ disease (GD). Both pathologies are characterized by oxidative stress (OS), the production of reactive oxygen species (ROS) exceeding the antioxidant defenses. The aim of this study is to correlate cav1 expression and OS in HT and GD. Primary cultures of human thyrocytes were treated o...

ea0084op-05-23 | Oral Session 5: Autoimmunity | ETA2022

Cut-offs for thyroid peroxidase and thyroglobulin antibodies in early pregnancy are not similar and may differ from non-pregnant individuals: evidence from 10,905 danish pregnant women

Linding Andersen Stine , Henrik Bruun Niels , Astrup Christensen Peter , Lykkeboe Simon , Handberg Aase , Bo Hansen Annebirthe , Berg Hjelm Maja , Knosgaard Louise , Maria Uldall Torp Nanna , Carle Allan , Scott Karmisholt Jesper , Bulow Pedersen Inge , Vestergaard Peter , Andersen Stig

Objectives: Thyroid disease in women of reproductive age is predominantly of autoimmune origin, and thyroid peroxidase antibodies (TPO-Ab) as well as thyroglobulin antibodies (Tg-Ab) are key markers of autoimmune hypothyroidism. Adding to this, much focus in pregnancy is on euthyroid women who are positive for thyroid autoantibodies. The observational findings are diverse, and evidence to substantiate the applied cut-offs for definition of thyroid autoantibody-positivity in ea...

ea0084op-05-24 | Oral Session 5: Autoimmunity | ETA2022

Sirolimus for graves’ orbitopathy: A novel drug for the management of patients with moderate-to-severe graves’ orbitopathy?

Lanzolla Giulia , Novella Maglionico Maria , Comi Simone , Menconi Francesca , Posarelli Chiara , Figus Michele , Marcocci Claudio , Marino' Michele

Background: Sirolimus is an immunosuppressive drug with anti-fibrotic and anti-proliferative activities. In vitro, sirolimus inhibits differentiation of orbital fibroblasts from patients with Graves’ orbitopathy (GO), suggesting a possible use in clinical practice.Methods: We performed a retrospective investigation aimed at evaluating the effects of sirolimus as a second-line treatment for moderate-to-severe, active GO, compared with methyl...

ea0084op-05-25 | Oral Session 5: Autoimmunity | ETA2022

Intestinal barrier permeability in patients with hashimoto’s thyroiditis associated to non-endocrine autoimmune disorders

Virili Camilla , Stramazzo Ilaria , Capriello Silvia , Brusca Nunzia , Flavia Bagaglini Maria , Nocella Cristina , Carnevale Roberto , Centanni Marco

Objective: Intestinal barrier (IB) is one of the wider human body surface, whose integrity allows the uptake of nutrients also preserving from the entrance of harmful compounds. An increased permeability of IB, known as “leaky gut”, has been demonstrated in patients with intestinal inflammatory and/or autoimmune disorders as well as in patients with autoimmune diseases involving organs far from the intestine, as in patients with Hashimoto’s thyroiditis (HT). The...

ea0084op-05-26 | Oral Session 5: Autoimmunity | ETA2022

Prospective single blind, usa-based, multicenter comparison of tsh-receptor antibody immunoassays

Lupo Mark , Little Amy , Hatun Burak , Kahaly George

Objective: The performance of two functional bioassays and two immunoassays for the measurement of TSHR-Ab was assessed in this multicenter study.Methods: Two-hundred two subjects (median age 54 years, 162 female, 80%), with well-documented thyroid disorders and controls were prospectively enrolled in a consecutive, unselected manner. Antibody measurements were performed in a blinded manner using the Bridge (Siemens, performed at the Dartmouth-Hitchcock ...