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44th Annual Meeting of the European Thyroid Association (ETA) 2022

Brussels, Belgium
10 Sep 2022 - 13 Sep 2022

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Oral Presentations

Oral Session 6: Hypothyroidism

ea0084op-06-27 | Oral Session 6: Hypothyroidism | ETA2022

Evaluation of dried blood spot thyroglobulin as a biomarker for iodine status in pregnant women and newborns

Fuentes Pena Camilo , Riedel Soria Claudia , Moreno-Reyes Rodrigo

Background: Thyroglobulin (Tg) is a promising biomarker for monitoring iodine nutrition in children and pregnant women. The determination of Tg in dried blood spots (DBS) offers many logistical advantages, simplifying the collection, transport, and storage of samples. The present study aimed to validate an ELISA assay for Tg determination in newborns.Methods: Tg-DBS samples were measured in 196 newborns born from healthy pregnant women. The different cri...

ea0084op-06-28 | Oral Session 6: Hypothyroidism | ETA2022

The optimal ranges of thyroid function based on the risk of cardiovascular disease and mortality: an individual participant data meta-analysis

Xu Yanning , Derakhshan Arash , Wildisen Lea , Hysaj Ola , Iacoviello Massimo , Ceresini Graziano , Ferrucci Luigi , Iervasi Giorgio , Pingitore Alessandro , Vaes Bert , Gussekloo Jacobijn , Medici Marco , Galesloot Tessel , P. F. Dullaart Robin , J.L. Bakker Stephan , Wouter Jukema J. , Trompet Stella , Westendorp Rudi , Ittermann Till , Volzke Henry , Dorr Marcus , Schmidt Borge , Fuhrer Dagmar , J. Wareham Nicholas , Boelaert Kristien , Razvi Salman , P. J. Vanderpump Mark , Muendlein Axel , Drexel Heinz , Bensenor Isabela , Sgarbi Jose , C. Bauer Douglas , A. Fink Howard , M. Rhee Connie , Azizi Fereidoun , Imaizumi Misa , B. Yeap Bu , Hankey Graeme , J. Brown Suzanne , P. Walsh John , Korevaar Tim , Rodondi Nicolas , R. Cappola Anne , Peeters Robin , Chaker Layal , the Thyroid Studies Collaboration for

Background and Objective: Thyroid function reference ranges are statistically defined by the 2.5th and 97.5th percentiles, which do not account for potential risk of clinical outcomes. We aimed to define the optimal ranges of thyroid-stimulating hormone (TSH) and free thyroxine (FT4), based on the risk of cardiovascular disease (CVD) and mortality.Methods: We performed an individual-participant data analysis and identified prospecti...

ea0084op-06-29 | Oral Session 6: Hypothyroidism | ETA2022

Central hypothyroidism ensuing endonasal transsphenoidal pituitary surgery: the role of a post operative trh stimulation test

Claus Mathieu , Lapauw Bruno , T' sjoen Guy

Objectives: The goal of this study was to evaluate the value of a TRH stimulation test to assess the risk of permanent central hypothyroidism after transsphenoidal pituitary surgery.Methods: A retrospective cohort study was performed, evaluating the results of a routinely performed TRH stimulation test executed in the first 2 weeks after transsphenoidal pituitary surgery in patients admitted to the Ghent University Hospital between 1/1/2010 and 31/12/201...

ea0084op-06-30 | Oral Session 6: Hypothyroidism | ETA2022

Levothyroxine replacement therapy overuse and factors guiding successful treatment discontinuation: short and long-term observation data of a large cohort

Livadas Sarantis , Androulakis Ioannis , Angelopoulos Nikolaos , Anagnostis Panagiotis , Paparodis Rodis , Boniakos Anastasios , Askitis Dimitrios , Duntas Leonidas

Background: Levothyroxine (LT4Rx) is one of the most prescribed drugs worldwide the vast majority of patients receive long-term treatment. However, in a recent study of 291 subjects, it was found that 60% were euthyroid 2 months after LT4-Rx discontinuation1.Aim of the study: A prospective clinical cohort follow-up study was carried out. In 688 subjects (82% females) aged 48.01±15.96 (range 17-84years) with 8.59±6.98 years on LT4Rx witho...

ea0084op-06-31 | Oral Session 6: Hypothyroidism | ETA2022

Does subclinical hypothyroidism add on any symptoms? evidence from a danish population-based study

Carle Allan , Karmisholt Jesper , Knudsen Nils , Perrild Hans , Thuesen Betina , Ovesen Lars , B Rasmussen Lone , Bulow Pedersen Inge

Background: Few studies have scrutinized the spectrum of symptoms in subclinical hypothyroidism.Methods: From three DanThyr cross-sectional surveys performed in the period 1997 to 2005, a total of 8,903 volunteers participated in a comprehensive investigation including blood samples and questionnaires on previous diseases, smoking habits, alcohol intake, and education. From the three surveys we included patients with unknown subclinical hypothyroidism (<...