Searchable abstracts of presentations at key conferences in endocrinology

ea0077p44 | Metabolism, Obesity and Diabetes | SFEBES2021

11β-HSD1 determines the extent of muscle atrophy during an acute exacerbation of COPD

Michelle Webster Justine , Waaijenberg Kelsy , Worp Wouter van de , Lambrichts Sara , Lavery Gareth , Hardy Rowan S , Langen Ramon

Introduction: Muscle atrophy is a major clinical complication of acute exacerbations (AE) in chronic obstructive pulmonary disease (COPD). The enzyme 11 beta-hydroxysteroid dehydrogenase 1 (11β-HSD1) activates glucocorticoids (GCs) within muscle, is induced by inflammation, and has been shown to contribute towards GC-induced muscle wasting. In this study, we examined the role of 11β-HSD1 in this context using a murine model of COPD-AE in animals with transgenic globa...