Searchable abstracts of presentations at key conferences in endocrinology

ea0032p829 | Pituitary–Basic (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

mTOR mediated IGF1 proliferative effects on a rat pituitary GH/PRL secreting pituitary adenoma cell line

Bellio Mariaenrica , Mirabassi Cecilia , Gagliano Teresa , Uberti Ettoredegli , Chiara Zatelli Maria

IGF1 represents an important growth factor in pituitary physiology and pathology, also mediating the negative feed-back mechanisms on somatotroph axis. It has been previously demonstrated that IGF1 promotes cell viability in primary cultures of human non functioning pituitary adenomas, by a mechanisms involving, at least in part, mTOR signaling, which is involved in many pathways controlling proliferation. We aimed at investigating whether mTOR may mediate IGF1 effects also in...