Searchable abstracts of presentations at key conferences in endocrinology

ea0029p1292 | Paediatric endocrinology | ICEECE2012

Systemic administration of C-type natriuretic peptide rescues impaired endochondral bone growth in mice model of achondroplasia

Yasoda A. , Fujii T. , Kondo E. , Nakao K. Koyama N. , Yamashita Y. , Ueda Y. , Kanamoto N. , Sone M. , Miura M. , Arai H. , Nakao K.

Introduction: Recent studies have elucidated that C-type natriuretic peptide (CNP), a member of natriuretic peptide family, is a potent stimulator of endochondral bone growth; CNP and its membranous guanylyl cyclase receptor, GC-B are expressed in growth plate, and mice with targeted overexpression of CNP in growth plate exhibit prominent skeletal overgrowth, whereas CNP or GC-B knockout mice develop severely short stature phenotype owing to their impaired endochondral bone gr...

ea0029p1608 | Thyroid (non-cancer) | ICEECE2012

FOXA1 and FOXA2 oppositely regulate human type 1 Iodothyronine deiodinase gene in liver

Kanamoto N. , Tagami T. , Ueda Y. , Miura M. , Yasoda A. , Arai H. , Nakao K.

Type 1 iodothyronine deiodinase (D1), a selenoenzyme that catalyzes the bioactivation of thyroid hormone, is expressed mainly in the liver. Its expression and activity are modulated by several factors, but the precise mechanism of its transcriptional regulation remains unclear. In the present study, we have analyzed the promoter of human D1 (hDIO1) gene to identify factors that prevalently increase D1 activity in the human liver. Deletion and mutation analyses demonstrated tha...

ea0029p77 | Adrenal cortex | ICEECE2012

Significance of ACTH stimulation test in the diagnosis of an aldosterone-producing adenoma

Sonoyama T. , Sone M. , Miyashita K. , Tamura N. , Yamahara K. , Park K. , Oyamada N. , Taura D. , Inuzuka M. , Kojima K. , Honda K. , Fukunaga Y. , Kanamoto N. , Miura M. , Yasoda A. , Arai H. , Itoh H. , Nakao K.

Primary aldosteronism (PA) is a major cause of secondary hypertension. Among PA, the diagnosis of an aldosterone-producing adenoma (APA) is critical because an APA can be cured surgically. Adrenal venous sampling (AVS) is the golden standard test in the diagnosis of an APA, but is available only in specialized medical centers. Meanwhile, aldosterone secretion of an APA is reported to be more sensitive to ACTH than that of idiopathic hyperaldosteronism (IHA) or essential hypert...