Searchable abstracts of presentations at key conferences in endocrinology

ea0074ncc38 | Highlighted Cases | SFENCC2021

Perinatal headaches and the postpartum diagnosis

Trainer Harris , Modi Manish , Caterson Jessica , Agha-Jaffar Rochan

Case history: A 42-year old female was urgently referred to the endocrinology clinic. Symptomatology included worsening lethargy, polydipsia, poor appetite, postural dizziness and hypogalactia. Relevant background included the delivery of a healthy baby at term four weeks prior (Emergency caesarean section, 1000 ml blood loss documented). She had undergone an MRI at 39 weeks gestation following a 10-day history of persistent headaches with associated photophobia and dizziness ...

ea0038p4 | Bone | SFEBES2015

Mutations in G-protein subunit αq (GNAQ) are not a cause of familial hypocalciuric hypercalcaemia

Modi Manish , Cranston Treena , Rogers Angela , Howles Sarah , Gorvin Caroline , Thakker Rajesh

Familial hypocalciuric hypercalcaemia (FHH) is an autosomal dominant disorder characterised by hypercalcaemia and inappropriately low renal calcium excretion. FHH can be classified into three types: FHH1, caused by calcium-sensing receptor (CaSR) loss-of-function mutations, accounting for >65% of cases; FHH2, due to loss-of-function mutations of the G-protein α11 subunit (Gα11); and FHH3, resulting from loss-of-function mutations in the adap...

ea0028p32 | Clinical biochemistry | SFEBES2012

Vitamin D deficiency is associated with worsened biochemical features and poorer diagnostic accuracy in patients with primary hyperparathyroidism

Modi Manish , Jayasena Channa , Palazzo Fausto , Donaldson Mandy , Meeran Karim , Dhillo Waljit

Background: Vitamin D deficiency is a common feature of primary hyperparathyroidism (PHP). However, replacement of vitamin D is not routinely performed in clinical practice, due to concerns about its safety. Furthermore, it is not clear whether vitamin D deficiency worsens the biochemical derangements observed in patients with PHP.Aim: To determine the relationship between 25(OH) vitamin D status and biochemical markers in patients with PHP.<p class=...

ea0094p267 | Reproductive Endocrinology | SFEBES2023

Kallmann syndrome with unilateral anosmia

Tsoutsouki Jovanna , N Comninos Alexander , Phylactou Maria , Chia Eng Pei , Patel Bijal , Modi Manish , Young Megan , Papadopoulou Deborah , R Howard Sasha , S Dhillo Waljit , Abbara Ali

Introduction: Kallmann syndrome (KS) is a rare genetic disorder typically due to defective migration of olfactory-axons and GnRH-neurons. KS results in congenital hypogonadotrophic hypogonadism (CHH) typically associated with absent (anosmia) or reduced (microsmia) sense of smell. Unilateral hypoplastic/absent olfactory bulbs on MRI are reported, although disturbance in smell is usually bilateral. Here, we present an unusual case of KS with unilateral anosmia....

ea0077oc1.1 | Reproductive and Neuroendocrinology | SFEBES2021

Melanocortin-4 receptor agonism improves sexual brain processing in women with low sexual desire

Thurston Layla , Hunjan Tia , Mills Edouard , Wall Matthew , Ertl Natalie , Phylactou Maria , Muzi Beatrice , Patel Bijal , Alexander Emma , Suladze Sofiya , Modi Manish , Eng Pei , Bassett Paul , Abbara Ali , Goldmeier David , Comninos Alexander , Dhillo Waljit

Hypoactive sexual desire disorder (HSDD) is the most prevalent female sexual health complaint worldwide, affecting 1-in-10 women. It is characterised by a persistent lack of desire for sexual activity and sexual fantasies, causing distress or interpersonal difficulties. Treatment options are limited, however, melanocortin-4 receptor (MC4R) agonists have emerged as a promising therapy for HSDD, through unclear mechanisms. Investigating the pathways involved is crucial for our u...

ea0081p151 | Pituitary and Neuroendocrinology | ECE2022

Sexual brain processing is enhanced by melanocortin-4 receptor agonism

Thurston Layla , Hunjan Tia , Mills Edouard , Wall Matt B , Ertl Natalie , Phylactou Maria , Muzi Beatrice , Patel Bijal , Alexander Emma , Suladze Sofiya , Modi Manish , Eng Pei , Bassett Paul , Abbara Ali , Goldmeier David , Comninos Alexander , Dhillo Waljit

Introduction: Hypoactive sexual desire disorder (HSDD) is characterized by a persistent deficiency of sexual fantasies and desire for sexual activity, causing marked distress or interpersonal difficulty. It is the most prevalent female sexual health problem worldwide, affecting approximately 1 in 10 women, but has limited treatment options despite its substantial health, social, and economic burden. Melanocortin-4 receptor (MC4R) agonists have emerged as a promising therapy fo...

ea0065p350 | Reproductive Endocrinology and Biology | SFEBES2019

Gonadotrophin rise following the kisspeptin analogue (MVT-602) is increased in women with hypothalamic amenorrhoea compared to healthy women

Eng Pei Chia , Abbara Ali , Phylactou Maria , Clarke Sophie A , Yang Lisa , Mills Edouard , Modi Manish , Papadopoulou Deborah , Plumptre Isabella , Hunjan Tia , Purugganan Kate , Webber Lisa , Salim Rehan , Comninos Alexander N , Dhillo Waljit S

Introduction: Hypothalamic amenorrhoea (HA) is a condition characterised by reduced GnRH pulsatility and is a common cause of anovulatory subfertility. Kisspeptin is an endogenous neuropeptide that regulates hypothalamic GnRH function. Hypothalamic kisspeptin expression is reduced, and kisspeptin receptor expression is increased, in a rodent model of HA. The kisspeptin analogue MVT-602 has a 3-4-fold longer half-life than native kisspeptin-54 (t1/2 0.5 h). We invest...

ea0065p366 | Reproductive Endocrinology and Biology | SFEBES2019

The effects of peptide-YY (PYY) on the reproductive axis in humans

Izzi-Engbeaya Chioma , Jones Sophie , Crustna Yoshibye , Machenahalli Pratibha , Papadopoulou Deborah , Modi Manish , Panayi Christos , Starikova Jessica , Eng Pei Chia , Phylactou Maria , Mills Edouard , Yang Lisa , Ratnasabapathy Risheka , Sykes Mark , Plumptre Isabella , Minnion James , Tharakan George , Tan Tricia , Veldhuis Johannes , Abbara Ali , Comninos Alexander , Dhillo Waljit

Introduction: Peptide-YY (PYY) is produced by intestinal L-cells following nutrient ingestion. PYY analogues are an emerging class of anti-obesity medication. Peripheral administration of PYY has potent anorectic effects in rodents and humans. Interestingly, rodent studies have demonstrated that PYY has additional effects on reproductive hormone secretion depending on the model studied. In humans, hypogonadism occurs in up to 40% of men with obesity. Therefore, the effects of ...